Stochastic Modeling of Autoregulatory Genetic Feedback Loops: A Review and Comparative Study.

07:00 EST 25th February 2020 | BioPortfolio

Summary of "Stochastic Modeling of Autoregulatory Genetic Feedback Loops: A Review and Comparative Study."

Autoregulatory feedback loops are one of the most common network motifs. A wide variety of stochastic models have been constructed to understand how the fluctuations in protein numbers in these loops are influenced by the kinetic parameters of the main biochemical steps. These models differ according to 1) which subcellular processes are explicitly modeled, 2) the modeling methodology employed (discrete, continuous, or hybrid), and 3) whether they can be analytically solved for the steady-state distribution of protein numbers. We discuss the assumptions and properties of the main models in the literature, summarize our current understanding of the relationship between them, and highlight some of the insights gained through modeling.


Journal Details

This article was published in the following journal.

Name: Biophysical journal
ISSN: 1542-0086


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