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Emergence of Five Genetic Lines ST395, ST13, ST3346, ST39, and Novel ST3551 of Multidrug-Resistant Clinical in Russia.

08:00 EDT 9th March 2020 | BioPortfolio

Summary of "Emergence of Five Genetic Lines ST395, ST13, ST3346, ST39, and Novel ST3551 of Multidrug-Resistant Clinical in Russia."

The objective of this study was phenotypic and genotypic characterization of antibacterial-resistant clinical strains isolated in Moscow Transplantology Intensive Care Unit in 2017-2019. Major strains among ( = 63) isolated from 30 patients were recognized as extensive drug-resistant ( = 55) pathogens, and remaining strains were recognized as multidrug-resistant ( = 8) pathogens. The beta-lactamase genes ( = 63), ( = 61), ( = 54), ( = 52), and ( = 2), as well as class 1 integrons ( = 19) carried gene cassette arrays A4 ( = 2), A1C ( = 6), BA1 ( = 9), A15A1 ( = 3), and A12 ( = 1) were identified in the strains. All strains carried four virulence genes: G, H, , and S, but two strains had additionally gene. Six known sequence types (STs) of ST395 ( = 44), ST377 ( = 3), ST307 ( = 4), ST13 ( = 2), ST39 ( = 2), ST3346 ( = 1), and a novel sequence-type ST3551 ( = 7) were identified. Phylogenetic analysis showed that ST3551 belonged to the cluster of clonal group CG147, and the remaining six STs to the another cluster consisting of four subgroups. The emergence of genetic lines carrying epidemiologically significant beta-lactamase genes ST395, ST13, ST3346, ST3551, and ST39 was the first case of detection in Russia. The emergence of novel carbapenemase-producing genetic lines in Russia highlights the global negative tendency of multidrug-resistant pathogens spread in high-technological medical centers.

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Name: Microbial drug resistance (Larchmont, N.Y.)
ISSN: 1931-8448
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