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AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides.

08:00 EDT 10th March 2020 | BioPortfolio

Summary of "AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides."

We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.

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This article was published in the following journal.

Name: Journal of the American Chemical Society
ISSN: 1520-5126
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Medical and Biotech [MESH] Definitions

Modified oligonucleotides in which one of the oxygens of the phosphate group is replaced with a sulfur atom.

Complex compounds in which a dumbbell shaped molecule is encircled by a macrocycle. They are named after rota (wheel) and axis (axle). Notation with a prefix is used to indicate the number of interlocked components. They have potential use in NANOTECHNOLOGY. Rotaxanes have been made with CYCLODEXTRINS and CYCLIC ETHERS.

Short fragments of DNA or RNA that are used to alter the function of target RNAs or DNAs to which they hybridize.

Enzymes that catalyze the hydrolysis of the internal bonds and thereby the formation of polynucleotides or oligonucleotides from ribo- or deoxyribonucleotide chains. EC 3.1.-.

Chemically-engineered oligonucleotides used to selectively inhibit expression of target genes through sequence-specific binding of corresponding microRNA (miRNA) sites.

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