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A Share 21 Model in Liver Transplantation: Impact on Waitlist Outcomes.

08:00 EDT 10th March 2020 | BioPortfolio

Summary of "A Share 21 Model in Liver Transplantation: Impact on Waitlist Outcomes."

With the introduction of MELD-Na based allocation, the score at which patients benefit from liver transplantation (LT) has shifted from a score of 15 to 21. This study aimed to evaluate waitlist outcomes in patients with MELD-Na scores <21 and explore the utility of replacing "Share 15" with "Share 21". The study uses data from the OPTN/UNOS registry. All adult patients registered for LT after implementation of the MELD-Na based allocation were evaluated. Waitlist patients with initial and final scores <21 were eligible. Patients with exception scores were excluded. To explore the potential impact of a Share 21 model, patients with an initial MELD-Na score of 6-14 (Group 1) and those with a score of 15-20 (Group 2) were compared for waitlist outcomes. There were 3,686 patients with an initial score of 6-14 (Group 1) and 3,282 with a score of 15-20 (Group 2). Group 2, when compared to Group 1, showed comparable risk of mortality (adjusted hazard ratio [aHR] 1.00, P=0.97), higher transplant probability (aHR 3.25, P<0.001), and lower likelihood of removal from listing because of improvement (aHR 0.74, P=0.011). Share 21 may enhance transplant opportunities and increase parity for patients with higher MELD-Na scores without compromising waitlist outcomes.

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This article was published in the following journal.

Name: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Pages:

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Transplantation between individuals who share a partial haplotype match.

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The transference of a part of or an entire liver from one human or animal to another.

Conditions in which the LIVER functions fall below the normal ranges. Severe hepatic insufficiency may cause LIVER FAILURE or DEATH. Treatment may include LIVER TRANSPLANTATION.

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