Topics

Sphingosine-1-phosphate (S1P) receptors: Promising drug targets for treating bone-related diseases.

08:00 EDT 10th March 2020 | BioPortfolio

Summary of "Sphingosine-1-phosphate (S1P) receptors: Promising drug targets for treating bone-related diseases."

Sphingosine-1-phosphate (S1P) is a natural bioactive lipid molecule and a common first or second messenger in the cardiovascular and immune systems. By binding with its receptors, S1P can serve as mediator of signalling during cell migration, differentiation, proliferation and apoptosis. Although the predominant role of S1P in bone regeneration has been noted in many studies, this role is not as well-known as its roles in the cardiovascular and immune systems. In this review, we summarize previous research on the role of S1P receptors (S1PRs) in osteoblasts and osteoclasts. In addition, S1P is regarded as a bridge between bone resorption and formation, which brings hope to patients with bone-related diseases. Finally, we discuss S1P and its receptors as therapeutic targets for treating osteoporosis, inflammatory osteolysis and bone metastasis based on the biological effects of S1P in osteoclastic/osteoblastic cells, immune cells and tumour cells.

Affiliation

Journal Details

This article was published in the following journal.

Name: Journal of cellular and molecular medicine
ISSN: 1582-4934
Pages:

Links

DeepDyve research library

PubMed Articles [22654 Associated PubMed Articles listed on BioPortfolio]

FUNCTIONAL CONTRIBUTION OF SPHINGOSINE-1-PHOSPHATE TO AIRWAY PATHOLOGY IN CIGARETTE SMOKE EXPOSED MICE.

A critical role for sphingosine kinase/sphingosine-1-phosphate pathway in the control of airway function has been demonstrated in respiratory diseases. Here, we address sphingosine-1-phosphate contrib...

The role of sphingosine 1-phosphate metabolism in bone and joint pathologies and ectopic calcification.

Sphingolipids display important functions in various pathologies such as cancer, obesity, diabetes, cardiovascular or neurodegenerative diseases. Sphingosine, sphingosine 1-phosphate (S1P), and cerami...

Study of Intercellular Adhesion Molecule-1 (ICAM-1) on Bone Homeostasis.

Although studies established role of integrins in bone homeostasis, especially in osteoclastogenesis, have been a novel and promising therapeutic drug target for bone loss diseases, such as: osteolysi...

A mechanism-based sphingosine-1-phosphate lyase inhibitor.

The synthesis of a series of vinylated analogs of sphingosine-1-phosphate, together with their unambiguous configurational assignment by VCD methods is reported. Among them, compound RBM10-8 can irrev...

The endocannabinoid system: Novel targets for treating cancer induced bone pain.

Treating Cancer-induced bone pain (CIBP) continues to be a major clinical challenge and underlying mechanisms of CIBP remain unclear. Recently, emerging body of evidence suggested the endocannabinoid ...

Clinical Trials [16344 Associated Clinical Trials listed on BioPortfolio]

Anti-Inflammatory Pulmonal Therapy of CF-Patients With Amitriptyline and Placebo

Our data indicate that the CFTR-molecule functions as a transporter for sphingosine-1-phosphate and sphingosine or regulates the uptake of these sphingolipids by epithelial cells. The dist...

Sphingosine-1-phosphate in Asthma

This study is being undertaken in order to enhance our understanding how human airways are being constricted in healthy people and in individuals with asthma. There is an unmet need for id...

Sphingosine-1-phosphate and Pneumonia

Pneumonia is a major infectious cause of death worldwide and imposes a considerable burden on healthcare resources. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid and involved i...

Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE)

During end-stage kidney disease, clinical guidelines suggest reducing elevated phosphate levels in the blood. However, the effect of lowering blood phosphate levels on important patient-ce...

Evaluation of Plasma Sphingosine-1-Phosphate as A Diagnostic and Prognostic Biomarkers of Community-Acquired Pneumonia

Pneumonia is a major infectious cause of death worldwide and imposes a considerable burden on healthcare resources. Obstructive lung diseases (COPD and Asthma) are increasingly important c...

Medical and Biotech [MESH] Definitions

A subfamily of lysophospholipid receptors with specificity for LYSOSPHINGOLIPIDS such as sphingosine-1-phosphate and sphingosine phosphorylcholine.

A sphingosine-derivative and IMMUNOSUPPRESSIVE AGENT that blocks the migration and homing of LYMPHOCYTES to the CENTRAL NERVOUS SYSTEM through its action on SPHINGOSINE 1-PHOSPHATE RECEPTORS. It is used in the treatment of MULTIPLE SCLEROSIS.

A family of G-protein-coupled receptors that bind to specific LYSOPHOSPHOLIPIDS such as lysophosphatidic acid and lysosphinglipids such as sphingosine-1-phosphate. They play an important role in the formation and function of the CARDIOVASCULAR SYSTEM.

Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.

Proteins that bind specific drugs with high affinity and trigger intracellular changes influencing the behavior of cells. Drug receptors are generally thought to be receptors for some endogenous substance not otherwise specified.

Quick Search


DeepDyve research library

Relevant Topics

Pharmacy
Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...

Osteoporosis
Osteoporosis is a disease in which the bones become extremely porous, are subject to fracture, and heal slowly, occurring especially in women following menopause and often leading to curvature of the spine from vertebral collapse. Follow and track&n...


Searches Linking to this Article