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Enhanced Stability of Peptide Nanofibers Coated with a Conformal Layer of Polydopamine.

08:00 EDT 10th March 2020 | BioPortfolio

Summary of "Enhanced Stability of Peptide Nanofibers Coated with a Conformal Layer of Polydopamine."

The susceptibility of self-assembled materials to changes in environmental conditions and mechanical forces often limits their utility for many applications. In this work, the surface of nanofibers formed by  β -sheet peptide self-assembly were coated by polydopamine (PDA) deposition. This conformal coating process rendered the nanofiber dimensions and internal  p -stacking chirality impervious to changes in pH, temperature and physical processing by spin-coating onto a silicon wafer. Whereas, sonication-induced shearing of the DA/NDI-KK composite irreversibly shortened the nanofibers into 100-200 nm segments, the uncoated nanofibers unravelled into single strands upon similar treatment. Additionally, the PDA coated nanofibers could be wrapped by an additional layer comprised of a positively, charged polyelectrolyte polymer.

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Name: Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
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