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Serum IgG antibody titer to Fusobacterium nucleatum is associated with unfavorable outcome after stroke.

08:00 EDT 10th March 2020 | BioPortfolio

Summary of "Serum IgG antibody titer to Fusobacterium nucleatum is associated with unfavorable outcome after stroke."

Stroke can be a cause of death, while in non-fatal cases it is a common cause of various disabilities resulting from associated brain damage. However, whether a specific periodontal pathogen is associated with increased risk of unfavorable outcome after stroke remains unknown. We examined risk factors for unfavorable outcome following stroke occurrence including serum antibody titers to periodontal pathogens. The enrolled cohort included 534 patients who had experienced an acute stroke, who were divided into favorable (n=337) and unfavorable (n=197) outcome groups according to modified ranking scale (mRS) score determined at 3 months after onset (favorable: score 0 or 1, unfavorable: score 2 to 6. The associations of risk factors with unfavorable outcome, including serum titers of IgG antibodies to 16 periodontal pathogens, were examined. Logistic regression analysis showed that the initial National Institutes of Health stroke scale score (OR 1.24, 95% CI 1.18-1.31, P < 0.001) and C-reactive protein (OR 1.29, 95% CI 1.10-1.51, P=0.002) were independently associated with unfavorable outcome after stroke. Following adjustment with those, detection of the antibody for F. nucleatum ATCC 10953 in serum remained an independent predictor of unfavorable outcome (OR 3.12, 95% CI 1.55-6.29, P=0.002). Determination of the antibody titer to F. nucleatum ATCC 10953 in serum may be useful as a predictor of unfavorable outcome after stroke.

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This article was published in the following journal.

Name: Clinical and experimental immunology
ISSN: 1365-2249
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A species of gram-negative, anaerobic, rod-shaped bacteria isolated from the gingival margin and sulcus and from infections of the upper respiratory tract and pleural cavity.

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An acute or chronic GINGIVITIS characterized by redness and swelling, NECROSIS extending from the interdental papillae along the gingival margins, PAIN; HEMORRHAGE, necrotic odor, and often a pseudomembrane. The condition may extend to the ORAL MUCOSA; TONGUE; PALATE; or PHARYNX. The etiology is somewhat unclear, but may involve a complex of FUSOBACTERIUM NUCLEATUM along with spirochetes BORRELIA or TREPONEMA.

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