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DCLK1 integrates induction of TRIB3, EMT, drug resistance and poor prognosis in colorectal cancer.

08:00 EDT 10th March 2020 | BioPortfolio

Summary of "DCLK1 integrates induction of TRIB3, EMT, drug resistance and poor prognosis in colorectal cancer."

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This article was published in the following journal.

Name: Carcinogenesis
ISSN: 1460-2180
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DCLK1 INTEGRATES INDUCTION OF TRIB3, EMT, DRUG RESISTANCE, and POOR PROGNOSIS IN COLORECTAL CANCER.

Doublecortin-like kinase 1 (DCLK1) promotes tumour proliferation in human colorectal cancer (CRC). To elucidate the mechanism and clinical relevance of this association, we performed expression analys...

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RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistance.

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TRIB3 roles in tumor progression have been revealed with similar or opposite results. Here, we found that TRIB3 expression was highly expressed in lung cancer tissues and correlated with tumor grades ...

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Medical and Biotech [MESH] Definitions

Initial drug treatment designed to bring about REMISSION INDUCTION. It is typically a short-term and high-dose drug treatment that is followed by CONSOLIDATION CHEMOTHERAPY and then MAINTENANCE CHEMOTHERAPY.

Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.

Simultaneous resistance to several structurally and functionally distinct drugs.

Containers, packaging, and packaging materials for drugs and biological products. These include those in ampule, capsule, tablet, solution or other forms. Packaging includes immediate-containers, secondary-containers, and cartons. In the United States, such packaging is controlled under the Federal Food, Drug, and Cosmetic Act which also stipulates requirements for tamper-resistance and child-resistance. Similar laws govern use elsewhere. (From Code of Federal Regulations, 21 CFR 1 Section 210, 1993) DRUG LABELING is also available.

Drug treatment designed to further diminish the disease toward complete remission following INDUCTION CHEMOTHERAPY. It helps to consolidate the gains during induction chemotherapy and may be followed by MAINTENANCE CHEMOTHERAPY.

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