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Advanced Treatment Options of Pyoderma Gangrenosum Ulcers.

07:00 EST 1st February 2020 | BioPortfolio

Summary of "Advanced Treatment Options of Pyoderma Gangrenosum Ulcers."

Pyoderma gangrenosum (PG) is a neutrophilic dermatosis often associated with autoimmune disease that, despite published literature, still poses diagnostic and therapeutic challenges due to its lack of serological and histological markers and wide possibility of differential diagnosis. Although immunosuppressive therapy usually is the first-line treatment, it has a long-lasting, unpredictable treatment course, thus necessitating the need for new treatment options. This report highlights 2 cases of PG ulcers treated with different methods that show a potentially faster healing time, as well as a review of advanced treatment options for PG.

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This article was published in the following journal.

Name: Wounds : a compendium of clinical research and practice
ISSN: 1943-2704
Pages: E1-E5

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PubMed Articles [21021 Associated PubMed Articles listed on BioPortfolio]

Identification and Evaluation of Outcome Measurement Instruments in Pyoderma Gangrenosum: A Systematic Review.

Pyoderma gangrenosum (PG) is a rare autoinflammatory skin condition that causes tissue destruction and subsequent painful ulcers. To date, there are no core domains or instruments for assessing PG sev...

Diagnosis and novel clinical treatment strategies for pyoderma gangrenosum.

: Pyoderma gangrenosum (PG) is a non-infectious, reactive inflammatory neutrophilic dermatosis that is commonly associated with autoimmune and neoplastic disorders. There are emerging diagnostic tools...

Gentian violet for pyoderma gangrenosum: a retrospective chart review.

Pyoderma gangrenosum is a rare autoinflammatory skin disease. Treatment is multifactorial, addressing inflammation, pain, underlying disease, if present, and the wound. Gentian violet has been used fo...

Pyoderma Gangrenosum Adverse Event with Rituximab Use: A post-marketing Pharmacovigilance Analysis.

Rituximab is a monoclonal antibody that is used for the treatment of certain malignancies and autoimmune conditions. Pyoderma gangrenosum is a rare painful ulcer that can be fatal in some cases and ca...

Surgical Management of Lower Extremity Pyoderma Gangrenosum With Viable Cryopreserved Umbilical Tissue: A Case Series.

Pyoderma gangrenosum (PG) is a rare skin disease that often presents as a uniquely painful and necrotic ulceration of the lower extremity. Pyoderma gangrenosum is often misdiagnosed and can have delet...

Clinical Trials [9418 Associated Clinical Trials listed on BioPortfolio]

Study to Determine the Safety and Efficacy of Adalimumab in the Treatment of Pyoderma Gangrenosum

The purpose of this research study is to see if Humira (adalimumab) is effective and safe in the treatment of pyoderma gangrenosum.

Exploratory Study of IFX-1 in Subjects With Pyoderma Gangrenosum

The purpose of this study is to determine whether IFX-1 is safe and effective in the treatment of pyoderma gangrenosum.

An Efficacy and Safety Study of Gevokizumab in Treating Active Ulcers of Pyoderma Gangrenosum

The study will evaluate the efficacy and safety of gevokizumab in treating active ulcers of pyoderma gangrenosum (PG).

Open Label Study for Adults With Pyoderma Gangrenosum and Inflammatory Bowel Disease

Subjects must be 18- 75 years old and have a history of both inflammatory bowels disease (Crohn's or ulcerative colitis) and pyoderma gangrenosum. This is a 6 month open label study of an...

Safety and Efficacy Study of Humira in Treatment of Pyoderma Gangrenosum

The purpose of this study is to determine the safety and efficacy of Humira in the treatment of pyoderma gangrenosum.

Medical and Biotech [MESH] Definitions

An idiopathic, rapidly evolving, and severely debilitating disease occurring most commonly in association with chronic ulcerative colitis. It is characterized by the presence of boggy, purplish ulcers with undermined borders, appearing mostly on the legs. The majority of cases are in people between 40 and 60 years old. Its etiology is unknown.

A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers.

A water insoluble terpene fatty acid used in the treatment of gastrointestinal ulcers; it facilitates the healing and function of mucosal tissue.

The detection of genetic variability (e.g., PHARMACOGENOMIC VARIANTS) relevant to PHARMACOGENETICS and PRECISION MEDICINE. The purpose of such genetic testing is to help determine the most effective treatment options and their optimum dosages with least potential risks for DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS.

An antagonist of histamine that appears to block both H2 and H3 histamine receptors. It has been used in the treatment of ulcers.

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