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Acute Radiation Therapy-related Dermatitis.

07:00 EST 1st February 2020 | BioPortfolio

Summary of "Acute Radiation Therapy-related Dermatitis."

Radiation therapy (RT) following breast-conserving surgical excision of cancer reduces cancer-related mortality and recurrence.1 However, most patients experience acute radiation dermatitis (ARD) within weeks after beginning RT2; symptoms of ARD, including severe skin erythema, dryness, moist or dry desquamation, and/or ulceration, may interrupt radiotherapy. This can negatively affect patient quality of life (QoL) and cancer outcomes. Acute radiation dermatitis is not to be confused with chronic radiation dermatitis, which can lead to fibrosis, skin atrophy, pigmentation, and telangiectasia months to years after RT.3 Evidence-based guidelines4 to both prevent and treat ARD recommend the application of 1 of 2 topical interventions during and/or after
RT:
(1) corticosteroids to improve ARD-related discomfort and itching5 or (2) 1% silver sulfadiazine (SSD) cream to reduce ARD-related dermatitis scores.6 This Evidence Corner reviews evidence supporting the 2 aforementioned topical interventions for patients undergoing RT for breast cancer.

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Journal Details

This article was published in the following journal.

Name: Wounds : a compendium of clinical research and practice
ISSN: 1943-2704
Pages: 66-68

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PubMed Articles [25928 Associated PubMed Articles listed on BioPortfolio]

Utility of topical agents for radiation dermatitis and pain: a randomized clinical trial.

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A systematic review and meta-analysis of clinician-reported versus patient-reported outcomes of radiation dermatitis.

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Melatonin Cream Against Acute Radiation Dermatitis in Patients With Early Breast Cancer

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Curcumin for the Prevention of Radiation-induced Dermatitis in Breast Cancer Patients

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Medical and Biotech [MESH] Definitions

A condition caused by a brief whole body exposure to more than one sievert dose equivalent of radiation. Acute radiation syndrome is initially characterized by ANOREXIA; NAUSEA; VOMITING; but can progress to hematological, gastrointestinal, neurological, pulmonary, and other major organ dysfunction.

Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.

Organs which might be damaged during exposure to a toxin or to some form of therapy. It most frequently refers to healthy organs located in the radiation field during radiation therapy.

Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other, e.g. military, purposes.

A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.

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