Protein Supported RuO2 Nanoparticles with Improved Catalytic Activity, in vitro Salt-Resistance and Biocompatibility: Colorimetric and Electrochemical Biosensing of Cellular H2O2.

08:00 EDT 10th March 2020 | BioPortfolio

Summary of "Protein Supported RuO2 Nanoparticles with Improved Catalytic Activity, in vitro Salt-Resistance and Biocompatibility: Colorimetric and Electrochemical Biosensing of Cellular H2O2."

Protein supported nanoparticles has a great significance in scientific and nanotechnology importance due to their "green" process, low cost-in-use, good biocompatibility and some interesting properties. Ruthenium oxide nanoparticles (RuO2NPs) have been considered to be an important member in nanotechnological research. However, the biosynthesis approach of RuO2NPs is relatively few compared to those of other nanoparticles. To address this challenge, this work presented a new way for RuO2NPs synthesis (BSA-RuO2NPs) supported by bovine serum albumin (BSA). BSA-RuO2NPs are confirmed to exert peroxidase-like activity, electro-catalytic activity, in vitro salt-resistance (2 M NaCl), and biocompatibility. Results indicate that BSA-RuO2NPs have higher affinity binding for 3, 3', 5, 5'-tetramethylbenzidine or H2O2 than bare RuO2NPs. Moreover, BSA turns out to be a crucial factor in promoting the stability of RuO2NPs. Taking these advantages of the improved properties, we established the colorimetric (Linear range from 2-800 μM, a limit of detection of 1.8 μM) and electrochemical (Linear range from 0.4-3850 μM, a limit of detection of 0.18 μM) biosensors for in-situ H2O2 monitoring from living MCF-7 cells. Herein, this work offers a new biosynthesis strategy to obtain BSA-RuO2NPs and sheds light on the sensitive biosensors to monitor the H2O2 secreted from living cells for promising application in nanotechnology, biology, biosensors and medicine.


Journal Details

This article was published in the following journal.

Name: ACS applied materials & interfaces
ISSN: 1944-8252


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