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Guttate leukoderma and acrokeratosis verruciformis of Hopf: a rare combination in Darier disease.

07:00 EST 15th January 2020 | BioPortfolio

Summary of "Guttate leukoderma and acrokeratosis verruciformis of Hopf: a rare combination in Darier disease."

A distinct Darier phenotype presenting with confetti-like hypopigmented macules was first described in 1965. Designated as "guttate leukoderma," this skin finding is a rarely-reported presentation of Darier disease. It has been theorized that the mutation in ATP2A2 causes defective E-cadherin, which in turn disrupts the adhesion of melanocytes to keratinocytes, thus leading to impaired dendrite formation, hindered melanin transfer, and ultimately to melanocyte apoptosis. Herein, we contribute a case of a 56-year old woman who presented with the rarely-described guttate leukoderma of Darier disease and acrokeratosis verruciformis of Hopf.

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Name: Dermatology online journal
ISSN: 1087-2108
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