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Twofold C-H annulation of readily available formamides and alkynes without built-in chelating groups was achieved, providing a series of chiral ferrocenes in 40-98% yield and 93-99% ee. Bulky chiral SPO ligand-enabled Ni-Al bimetallic catalysis proved to be critical to high reactivity and high selectivity.
This article was published in the following journal.
Name: Angewandte Chemie (International ed. in English)
C-H bond activation is mostly limited to ortho selectivity. Activation of both ortho and meta C-H bonds constitutes a particularly impotatant strategy for annulation, but this has been rarely studied ...
A highly efficient phosphine-catalyzed enantioselective [4 + 2] annulation of allenoates with 3-nitroindoles or 3-nitrobenzothiophenes has been developed. The protocol represents a unique dearomatiza...
A cobalt(II)-catalyzed [4+2] annulation of picolinamides with alkynes via C-H bond activation has been developed. The operationally simple annulation reaction allows us for the synthesis of acyl subst...
A bifunctional secondary phosphine oxide (SPO) ligand-controlled method was developed for Ni-Al-catalyzed nonchelated dual C-H annulation of arylformamides with alkynes, providing a series of substitu...
A highly enantioselective formal [4 + 2] annulation involving electron-deficient allenes as C2-synthons has been developed under bifunctional phosphonium salt catalysis. With this catalytic protocol, ...
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Open-label, two-period cross-over, patient-pilot study evaluating the safety, overall tolerability, and preliminary evidence of DST-0509 (investigational deferasirox tablets) iron chelatin...
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A chelating agent (CHELATING AGENTS) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive.
Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.
Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.
A group of amides with the general formula of R-CONH2.
A fluorescent calcium chelating agent which is used to study intracellular calcium in many tissues. The fluorescent and chelating properties of Fura-2 aid in the quantitation of endothelial cell injury, in monitoring ATP-dependent calcium uptake by membrane vesicles, and in the determination of the relationship between cytoplasmic free calcium and oxidase activation in rat neutrophils.