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Enantioselective Twofold C-H Annulation of Formamides and Alkynes without Built-in Chelating Groups.

08:00 EDT 10th March 2020 | BioPortfolio

Summary of "Enantioselective Twofold C-H Annulation of Formamides and Alkynes without Built-in Chelating Groups."

Twofold C-H annulation of readily available formamides and alkynes without built-in chelating groups was achieved, providing a series of chiral ferrocenes in 40-98% yield and 93-99% ee. Bulky chiral SPO ligand-enabled Ni-Al bimetallic catalysis proved to be critical to high reactivity and high selectivity.

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This article was published in the following journal.

Name: Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
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A chelating agent (CHELATING AGENTS) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive.

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