Significance of the Microfluidic Flow Inside the Organ of Corti.

08:00 EDT 12th March 2020 | BioPortfolio

Summary of "Significance of the Microfluidic Flow Inside the Organ of Corti."

We study the vibration modes of a short section in the middle turn of the gerbil cochlea including both longitudinal and radial interstitial fluid spaces between the pillar cells and hair cells to determine the role of the interstitial fluid flow within the organ of Corti (OoC). Three detailed finite element models of the cochlear short section (CSS) are studied. In Model 1, the CSS is without fluids; Model 2 includes the OoC fluid, but not the exterior scalae fluids; and Model 3 is the CSS with both scalae and OoC fluids. We find that: The fundamental mode shape (Mode 1) of Model 1 or Model 3 is similar to the classical basilar membrane (BM) bending mode that includes pivoting of the arch of Corti, and hence determines the low frequency vibrational mode shape of the cochlea in the presence of the cochlear wave; Mode 1 of Model 2 is characterized by a cross sectional shape change similar to the passive response of the cochlea and provides plausible modes of excitation of the hair cells; and the higher modes of Model 1 are similar to the electrically evoked response within the OoC and suggests that they are responsible for the active response of the cochlea. We observed that the fluid flow through the OoC interstitial space is significant, and the model comparison suggests that the OoC fluid contributes to the biphasic BM motion. The effect of fluid viscosity on cilium deflection was assessed by performing a transient analysis.


Journal Details

This article was published in the following journal.

Name: Journal of biomechanical engineering
ISSN: 1528-8951


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