Topics

Significance of the Microfluidic Flow Inside the Organ of Corti.

08:00 EDT 12th March 2020 | BioPortfolio

Summary of "Significance of the Microfluidic Flow Inside the Organ of Corti."

We study the vibration modes of a short section in the middle turn of the gerbil cochlea including both longitudinal and radial interstitial fluid spaces between the pillar cells and hair cells to determine the role of the interstitial fluid flow within the organ of Corti (OoC). Three detailed finite element models of the cochlear short section (CSS) are studied. In Model 1, the CSS is without fluids; Model 2 includes the OoC fluid, but not the exterior scalae fluids; and Model 3 is the CSS with both scalae and OoC fluids. We find that: The fundamental mode shape (Mode 1) of Model 1 or Model 3 is similar to the classical basilar membrane (BM) bending mode that includes pivoting of the arch of Corti, and hence determines the low frequency vibrational mode shape of the cochlea in the presence of the cochlear wave; Mode 1 of Model 2 is characterized by a cross sectional shape change similar to the passive response of the cochlea and provides plausible modes of excitation of the hair cells; and the higher modes of Model 1 are similar to the electrically evoked response within the OoC and suggests that they are responsible for the active response of the cochlea. We observed that the fluid flow through the OoC interstitial space is significant, and the model comparison suggests that the OoC fluid contributes to the biphasic BM motion. The effect of fluid viscosity on cilium deflection was assessed by performing a transient analysis.

Affiliation

Journal Details

This article was published in the following journal.

Name: Journal of biomechanical engineering
ISSN: 1528-8951
Pages:

Links

DeepDyve research library

PubMed Articles [9359 Associated PubMed Articles listed on BioPortfolio]

Pulsatile Flow in Microfluidic Systems.

This review describes the current knowledge and applications of pulsatile flow in microfluidic systems. Elements of fluid dynamics at low Reynolds number are first described in the context of pulsatil...

Transposing Lateral Flow Immunoassays to Capillary-Driven Microfluidics Using Self-Coalescence Modules and Capillary-Assembled Receptor Carriers.

Point-of-care (POC) immunodiagnostic tests play a crucial role in enabling rapid and correct diagnosis of diseases in prehospital care, emergency, and remote settings. In this work, we present a silic...

Blood flow analysis inside different arteries using non-Newtonian Sisko model for application in biomedical engineering.

In the present research, simulation of blood flow is carried out inside the artery with different radiuses of 0.002 m, 0.0025 m, 0.003 m, and 0.0035 m.

Two-phase flow in microfluidic-chip design of hydrodynamic filtration for cell particle sorting.

As one of the flow-based passive sorting, the hydrodynamic filtration (HDF) using a microfluidic-chip has shown to effectively separate into different sizes of subpopulations from cell or particle sus...

Microfluidic retention of progressively motile zebrafish sperms.

Genetic manipulation of zebrafish results in thousands of mutant strains and to efficiently preserve them for future use, zebrafish sperms have been cryopreserved in various cryopreservation centers. ...

Clinical Trials [5253 Associated Clinical Trials listed on BioPortfolio]

Non-invasive Fractional Flow Reserve CT (FFRCT)Scan for the Study of Coronary Vaso-motion

Coronary artery disease (CAD) is a very common cause of heart failure affecting millions of people worldwide, which is caused by build-up of plaque inside arteries of the heart. Build-up o...

The Evaluation of the Effect of Microfluidic Sperm Sorting Chip 'Labs-on-a-chip' on IVF Success in Male Factor

Microfluidic chips are one of the methods of sperm separation to eliminate DNA fragmentation in sperm. It is thought that the separation of sperm by centrifugation in the classical gradien...

4D Velocity Mapping of the Heart in rTOF Patients

MRI with 4D flow permits to assess the hemodynamic parameters in a parent vessel and its branches inside the same sequence. The objective of the project is to compare the regurgitant fract...

Sperm Selection by Microfluidic Separation Improves Embryo Quality in Patients With a History of Poor Embryo Quality

This is a randomized controlled trial of couples with a history of poor embryo quality undergoing a repeat in vitro fertilization (IVF) cycle for unexplained infertility. Couples will be r...

Comparison of the Effect of Microchip and Density Gradient Methods in Intrauterine Insemination Cycles

Microfluidic chips are one of the methods of sperm separation to eliminate DNA fragmentation in sperm. It is thought that the separation of sperm by centrifugation in the classical gradien...

Medical and Biotech [MESH] Definitions

The spiral EPITHELIUM containing sensory AUDITORY HAIR CELLS and supporting cells in the cochlea. Organ of Corti, situated on the BASILAR MEMBRANE and overlaid by a gelatinous TECTORIAL MEMBRANE, converts sound-induced mechanical waves to neural impulses to the brain.

Devices in which blood and oxygen are separated by a semipermeable membrane, generally of Teflon or polypropylene, across which gas exchange occurs. The membrane may be arranged as a series of parallel plates or as a number of hollow fibers; in the latter arrangement, the blood may flow inside the fibers, which are surrounded by gas, or the blood may flow outside the fibers and the gas inside the fibers. (Dorland, 28th ed)

A membrane, attached to the bony SPIRAL LAMINA, overlying and coupling with the hair cells of the ORGAN OF CORTI in the inner ear. It is a glycoprotein-rich keratin-like layer containing fibrils embedded in a dense amorphous substance.

NEURAL PATHWAYS and connections within the CENTRAL NERVOUS SYSTEM, beginning at the hair cells of the ORGAN OF CORTI, continuing along the eighth cranial nerve, and terminating at the AUDITORY CORTEX.

A tight junction-associated MARVEL protein that may play a role in separating the endolymphatic and perilymphatic spaces of the ORGAN OF CORTI. Defects in the gene that codes for MARVELD2 protein are a cause of deafness autosomal recessive type 49.

Quick Search


DeepDyve research library

Searches Linking to this Article