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The sex-specific role of p38 MAP kinase in CNS autoimmunity is regulated by estrogen receptor alpha.

07:00 EST 4th March 2020 | BioPortfolio

Summary of "The sex-specific role of p38 MAP kinase in CNS autoimmunity is regulated by estrogen receptor alpha."

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This article was published in the following journal.

Name: Journal of neuroimmunology
ISSN: 1872-8421
Pages: 577209

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Medical and Biotech [MESH] Definitions

One of the ESTROGEN RECEPTORS that has greater affinity for ISOFLAVONES than ESTROGEN RECEPTOR ALPHA does. There is great sequence homology with ER alpha in the DNA-binding domain but not in the ligand binding and hinge domains.

One of the ESTROGEN RECEPTORS that has marked affinity for ESTRADIOL. Its expression and function differs from, and in some ways opposes, ESTROGEN RECEPTOR BETA.

A ubiquitously expressed heterodimeric receptor that is specific for both INTERFERON-ALPHA and INTERFERON-BETA. It is composed of two subunits referred to as IFNAR1 and IFNAR2. The IFNAR2 subunit is believed to serve as the ligand-binding chain; however both chains are required for signal transduction. The interferon alpha-beta receptor signals through the action of JANUS KINASES such as the TYK2 KINASE.

A subunit of the interleukin-10 receptor. It plays a role in receptor signaling by associating with JANUS KINASE 1.

One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.

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