Track topics on Twitter Track topics that are important to you
Pulmonary complications are fatal adverse events after allo-HCT. On the other hand, smoking is a well-known risk factor for various pulmonary diseases and also increases the incidence of pulmonary complications and overall mortality in allo-HCT recipients. In this study, we retrospectively assessed the impact of smoking intensity on survival outcomes. This study included consecutive allo-HCT recipients at our center between June 2007 and May 2019 whose smoking profiles were available (n = 408); they were divided into high (pack-years > 10, n = 171) and low pack-years groups (pack-years ≤ 10, n = 231). In univariate analyses, non-relapse mortality (NRM) and overall survival (OS) were significantly inferior in the high pack-years group (1y-NRM 26.6% vs 13.9%, P <0.001, 1y-OS 58.4% vs 70.1%, P = 0.0067). However, this association was not observed in multivariate analyses. In subgroup analyses according to gender, the survival outcomes in the high pack-years group were significantly inferior in males (NRM HR 2.24 (95%
1.23 - 4.07), P = 0.0082; OS HR 1.54 (95%
1.04 - 2.28), P = 0.031), but not in females (NRM HR 0.587 (95%
0.241 - 1.43), P = 0.24; OS HR 0.689 (95%
0.400 - 1.19), P = 0.18). In summary, high pack-years was associated with inferior survival of allo-HCT recipients, especially in males.
This article was published in the following journal.
Relationships between microbiota composition and clinical outcomes after allogeneic hematopoietic-cell transplantation have been described in single-center studies. Geographic variations in the compos...
Infectious complications are significant causes of morbidity and mortality after allogeneic hematopoietic cell transplantation (allo-HCT). They occur variably over different periods, with scant data r...
Isavuconazole is a broad-spectrum triazole approved for treatment of invasive fungal infections (IFI). We evaluated isavuconazole for antifungal prophylaxis after allogeneic hematopoietic cell transpl...
Many patients with multiple myeloma (MM) eventually relapse even after curative intent allogeneic hematopoietic cell transplantation (HCT). Over the past decade, outcomes for patients with MM have si...
We aimed to investigate the frequency, risk factors, and outcome of active tuberculosis (TB) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). This retrospective, nested, case-cont...
Allogeneic stem cell transplantation, the only known curative modality for CML, was abandoned in recent years for a very effective and much less toxic targeted therapy with the tyrosine ki...
Graft failure is a lethal complication after allogeneic stem cell transplantation, which often need a salvage transplantation. However, the current outcome of second transplantation for gr...
Primary Objective: -To determine the dose and schedule combination of 5-Azacitidine, when used as maintenance treatment after allogeneic transplantation for high-risk AML / MDS. Se...
Pediatric patients are at high risk to acquire mycotic infections following allogeneic bone marrow transplantation. In the present retrospective analysis we assess the safety and efficacy ...
Acute lung injury (ALI) is an early complication after allogeneic transplantation causing significant mortality and morbidity. Little is known on early markers and treatment of this compli...
A decrease in the incidence and frequency of SMOKING. Smoking reduction differs from SMOKING CESSATION in that the smoker continues to smoke albeit at a lesser frequency without quitting.
A center in the PUBLIC HEALTH SERVICE which is primarily concerned with the collection, analysis, and dissemination of health statistics on vital events and health activities to reflect the health status of people, health needs, and health resources.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
Pipes for smoking tobacco, cannabis, and other substances, in which smoke is drawn through water. Do not confuse with SMOKING PIPES.
Gadgets, utensils, apparatuses or instruments used for SMOKING.
Organ transplantation is the moving of an organ from one body to another or from a donor site to another location on the patient's own body, for the purpose of replacing the recipient's damaged or absent organ. The emerging field of regenerative ...
Pulmonary relating to or associated with the lungs eg Asthma, chronic bronchitis, emphysema, COPD, Cystic Fibrosis, Influenza, Lung Cancer, Pneumonia, Pulmonary Arterial Hypertension, Sleep Disorders etc Follow and track Lung Cancer News ...