Effect of smoking on outcomes of allogeneic transplantation: a single center analysis.

08:00 EDT 18th March 2020 | BioPortfolio

Summary of "Effect of smoking on outcomes of allogeneic transplantation: a single center analysis."

Pulmonary complications are fatal adverse events after allo-HCT. On the other hand, smoking is a well-known risk factor for various pulmonary diseases and also increases the incidence of pulmonary complications and overall mortality in allo-HCT recipients. In this study, we retrospectively assessed the impact of smoking intensity on survival outcomes. This study included consecutive allo-HCT recipients at our center between June 2007 and May 2019 whose smoking profiles were available (n = 408); they were divided into high (pack-years > 10, n = 171) and low pack-years groups (pack-years ≤ 10, n = 231). In univariate analyses, non-relapse mortality (NRM) and overall survival (OS) were significantly inferior in the high pack-years group (1y-NRM 26.6% vs 13.9%, P <0.001, 1y-OS 58.4% vs 70.1%, P = 0.0067). However, this association was not observed in multivariate analyses. In subgroup analyses according to gender, the survival outcomes in the high pack-years group were significantly inferior in males (NRM HR 2.24 (95%
1.23 - 4.07), P = 0.0082; OS HR 1.54 (95%
1.04 - 2.28), P = 0.031), but not in females (NRM HR 0.587 (95%
0.241 - 1.43), P = 0.24; OS HR 0.689 (95%
0.400 - 1.19), P = 0.18). In summary, high pack-years was associated with inferior survival of allo-HCT recipients, especially in males.


Journal Details

This article was published in the following journal.

Name: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
ISSN: 1523-6536


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Medical and Biotech [MESH] Definitions

A decrease in the incidence and frequency of SMOKING. Smoking reduction differs from SMOKING CESSATION in that the smoker continues to smoke albeit at a lesser frequency without quitting.

A center in the PUBLIC HEALTH SERVICE which is primarily concerned with the collection, analysis, and dissemination of health statistics on vital events and health activities to reflect the health status of people, health needs, and health resources.

Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.

Pipes for smoking tobacco, cannabis, and other substances, in which smoke is drawn through water. Do not confuse with SMOKING PIPES.

Gadgets, utensils, apparatuses or instruments used for SMOKING.

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