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Lanthanide-doped nanoparticles (LnNPs) have gained increasing attention recently for bioimaging in the second near-infrared window (NIR-II, 1,000-1,700 nm) because of their excellent photophysical properties, but the construction of LnNPs-based activable probe responding to specific targets remains a challenge. Herein, we proposed an uncomplicated and universal strategy to fabricate LnNPs-based NIR-II probes by target-triggered dye-sensitization process. The dye acts as both the recognition motif of the target and a potential antenna for LnNPs, which can be activated by the target to sensitize the NIR-II luminescence of LnNPs. A proof-of-concept probe for glutathione (GSH) was constructed to validate this approach. It was able to track the fluctuation of GSH level in liver and lymphatic drainage and provide clear images with high contrast and resolution in vivo. This strategy can be generalized to construct NIR-II probes for various analytes by simply changing the recognition motif of the dye, greatly promoting the application of LnNPs.
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Together with the development of nanoscience, lanthanide (Ln)-doped upconversion nanoparticles (UCNPs), which can emit UV/VIS light upon irradiation by near-infrared laser sources, is emerging as one ...
Lanthanide-doped upconversion nanoparticles, converting near infrared light to visible emissions, are promising for a broad spectrum of biological applications spanning from imaging, sensing, to light...
Lateral flow immunoassay test (LFT), as a method of point of care test, is widely used in disease diagnosis, food security and environment observation, due to its portability and rapidity. Fluorescenc...
Upconversion nanoparticles (UCNPs) doped with lanthanide ions that possess ladder-like energy levels can give out multiple emissions at specific ultra-violet or visible wavelengths irrespective of exc...
Nanomaterials are subjects of extensive investigations due to their applications in medicine, multimodal imaging, volumetric displays, and photonics. Here, lanthanide-doped bismuth vanadate (BiVO4) up...
The hypothesis is that Addition of copper or zinc nanoparticles to a dental adhesive confers antimicrobial and enzymatic degradation-resistant properties, retaining its adhesion mechanical...
Silver nanoparticles are one of most nanoparticles use nowadays in the research area because it has specific physical and chemical properties, in medical fields silver nanoparticles can in...
The purpose of this study is to determine whether oral topic silver nanoparticles are effective to reduce potential pathogen microbial loads in mechanical ventilation patients.
This is a phase 1 clinical trial evaluating the safety, tolerability of escalating doses of AGuIX-NP in combination with radiation and cisplatin in patients with locally advanced cervical ...
The purpose of this study is to formally assess the efficacy and outcomes of optometrist-performed neodymium-doped yttrium aluminum garnet (Nd: YAG) laser capsulotomy procedures.
Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.
A psychological theory based on dimensions or categories used by a given person in describing or explaining the personality and behavior of others or of himself. The basic idea is that different people will use consistently different categories. The theory was formulated in the fifties by George Kelly. Two tests devised by him are the role construct repertory test and the repertory grid test. (From Stuart Sutherland, The International Dictionary of Psychology, 1989)
Teaching strategy of shared learning based cross-discipline experiences and placements.
A strategy for purchasing health care in a manner which will obtain maximum value for the price for the purchasers of the health care and the recipients. The concept was developed primarily by Alain Enthoven of Stanford University and promulgated by the Jackson Hole Group. The strategy depends on sponsors for groups of the population to be insured. The sponsor, in some cases a health alliance, acts as an intermediary between the group and competing provider groups (accountable health plans). The competition is price-based among annual premiums for a defined, standardized benefit package. (From Slee and Slee, Health Care Reform Terms, 1993)
Nanoparticles produced from metals whose uses include biosensors, optics, and catalysts. In biomedical applications the particles frequently involve the noble metals, especially gold and silver.
Hepatology is the study of liver, gallbladder, biliary tree, and pancreas, and diseases associated with them. This includes viral hepatitis, alcohol damage, cirrhosis and cancer. As modern lifestyles change, with alcoholism and cancer becoming more promi...