Oxylipin vanillyl acetals from Solanum lyratum.

08:00 EDT 18th March 2020 | BioPortfolio

Summary of "Oxylipin vanillyl acetals from Solanum lyratum."

Four undescribed oxylipin vanillyl acetals with four stereogenic carbons were isolated from the herbs of Solanum lyratum. A comprehensive set of spectroscopic methods were used to elucidate the structures and relative configurations of 1-4. The absolute configurations of the naturally occurring compounds are assigned as 7S, 9'S, 10'S, 11'R at the site of six-membered cyclic acetal attachment by electronic circular dichroism (ECD) calculations and the modified Mosher's method. Compounds 1 and 3 displayed moderate selective inhibition against Hep3B and HepG2 cells, respectively. Further Annexin V-FITC/PI staining assay revealed that 1 and 3 might have inhibitory effects on hepatoma cells through induction of apoptosis.


Journal Details

This article was published in the following journal.

Name: Fitoterapia
ISSN: 1873-6971
Pages: 104559


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Medical and Biotech [MESH] Definitions

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