Murine double minute-2 mediates exercise-induced angiogenesis in adipose tissue of diet-induced obese mice.

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Summary of "Murine double minute-2 mediates exercise-induced angiogenesis in adipose tissue of diet-induced obese mice."

This study aimed to determine the effects of physical exercise on the angio-adaptive response in adipose tissue following weight loss in a mouse model of diet-induced obesity. We hypothesized that physical exercise stimulates angiogenesis through the regulation of Vascular endothelial growth factor-A (VEGF-A) pro-/Thrombospondin-1 (TSP-1) anti-angiogenic signal under the control of the Murine double-minute 2/Forkhead box Os (Mdm2/FoxOs) axis, as reported in skeletal muscle.


Journal Details

This article was published in the following journal.

Name: Microvascular research
ISSN: 1095-9319
Pages: 104003


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