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The microsporidium Nosema bombycis is an obligate intracellular parasite of Bombyx mori and causes serious losses in the sericulture industry. The isobaric tags for relative and absolute quantitation (iTRAQ) methods have been used to study numerous pathogen-host interactions. Here, using iTRAQ technology, we explored the quantitative proteomics by gene ontology and KEGG. The proteins in the ovaries of B. mori infected with N. bombycis were identified and compared to those in uninfected ovaries by iTRAQ. A total of 5401 proteins were identified, and 70 of them were differentially expressed. The differentially quantified proteins were involved in a variety of important processes and pathways, such as host development, host metabolism or host defense system. Most proteins involved in basic metabolism were up-regulated following infection, and the expression levels of some proteins related to the host immunity, such as the lipid droplet protein prilipin, 30K proteins, HDD13, and beta-1,3-glucan recognition protein, were altered after infection with N. bombycis. Juvenile hormone acid methyltransferase, which regulates insect development, and ATG8, which is a key factor in autophagy, were also induced by N. bombycis infection. Our comparative and quantitative proteomic data will provide new insights into the interaction between N. bombycis and B. mori, especially in the host ovary.
This article was published in the following journal.
Name: Journal of invertebrate pathology
Invertebrates lack an adaptive immune response and thus are reliant on their innate immune response for eliminating invading pathogens. The innate immune responses of silkworms against the pathogen No...
Nosema bombycis is a pathogen of the silkworm that belongs to the microsporidia, a group of obligate intracellular parasites related to fungi. N. bombycis infection causes the disease pébrine in silk...
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Locations, on the GENOME, of GENES or other genetic elements that encode or control the expression of a quantitative trait (QUANTITATIVE TRAIT, HERITABLE).
Works consisting of studies using a quantitative method of combining the results of independent studies (usually drawn from the published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc. It is often an overview of clinical trials. It is usually called a meta-analysis by the author or sponsoring body and should be differentiated from reviews of literature.
The application of STATISTICS to biological systems and organisms involving the retrieval or collection, analysis, reduction, and interpretation of qualitative and quantitative data.
A characteristic showing quantitative inheritance such as SKIN PIGMENTATION in humans. (From A Dictionary of Genetics, 4th ed)
Computer-assisted study of methods for obtaining useful quantitative solutions to problems that have been expressed mathematically.
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Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...