Spleen contributes to restraint stress induced hepatocellular carcinoma progression.

08:00 EDT 20th March 2020 | BioPortfolio

Summary of "Spleen contributes to restraint stress induced hepatocellular carcinoma progression."

The spleen is the largest secondary immune organ and plays a critical role in the progression of tumor. Psychological stress promotes tumor progression through inhibiting antitumor immune. However, the role of spleen in tumor progression induced by stress is unclear. Here, we showed that restraint stress promoted tumor growth, increased the percentage of CD11bGr-1 MDSC while decreased the percentages of CD3NK1.1 NK and CD3NK1.1 NKT in the tumor tissues. Restraint stress decreased the percentages of CD3CD4 T lymphocytes and CD3CD8 T lymphocytes while increased the percentage of CD11bGr-1 MDSC in the blood of tumor-bearing mice. Restraint stress increased the percentages of CD3CD4 T lymphocytes, CD3CD8 T lymphocytes, CD4PD1 T lymphocytes and CD8PD1 T lymphocytes while decreased the percentage of CD11bGr-1 MDSC in the spleen of tumor-bearing mice. Interestingly, splenectomy inhibited tumor growth and attenuated the changes of CD3CD4 T lymphocytes, CD3CD8 T lymphocytes, and CD11bGr-1 MDSC in blood induced by chronic restraint stress. Finally, splenectomy blocked the increases of CD11bGr-1 MDSC but did not attenuate the decreases of CD3NK1.1 NK and CD3NK1.1 NKT in tumor tissue induced by chronic stress. Together, these data indicate that chronic restraint stress promotes hepatocellular carcinoma growth and suppresses the antitumor immunity of tumor-bearing mice. Splenectomy could inhibit tumor growth and partly block the decrease of antitumor immune activity induced by stress.


Journal Details

This article was published in the following journal.

Name: International immunopharmacology
ISSN: 1878-1705
Pages: 106420


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Medical and Biotech [MESH] Definitions

An ORTHOHEPADNAVIRUS causing chronic liver disease and hepatocellular carcinoma in woodchucks. It closely resembles the human hepatitis B virus.

The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum.

A congenital or acquired condition in which the SPLEEN is not in its normal anatomical position but moves about in the ABDOMEN. This is due to laxity or absence of suspensory ligaments which normally provide peritoneal attachments to keep the SPLEEN in a fixed position. Clinical symptoms include ABDOMINAL PAIN, splenic torsion and ISCHEMIA.

The first alpha-globulins to appear in mammalian sera during development of the embryo and the dominant serum proteins in early embryonic life. They reappear in the adult serum during certain pathologic states, primarily hepatocellular carcinoma. They may also be elevated in the amniotic fluid and maternal serum during pregnancy in ANENCEPHALY.

A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.

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