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Antibiotic contaminants have the potential to interfere with the control of cyanobacterial bloom through generating hormesis in cyanobacteria at current contamination level of ng L. This study investigated the influence of a mixture of four frequently detected antibiotics, amoxicillin, ciprofloxacin, sulfamethoxazole and tetracycline, during the treatment of Microcystis aeruginosa by copper sulfate (CuSO) algaecide. CuSO significantly (p < 0.05) inhibited cell density, growth rate, F/F value, chlorophyll a content and microcystin production ability of M. aeruginosa in a dose-dependent manner at application doses of 0.01-0.05 mg L. Besides, CuSO inhibited oxidation-reduction process, photosynthesis and biosynthesis in M. aeruginosa at the proteomic level. Preventative application of CuSO to a low density (4 × 10 cells mL) of M. aeruginosa effectively prevented the formation of bloom at low CuSO doses, which is a possible route for eliminating the negative effects of CuSO algaecide in aquatic environments. The presence of mixed antibiotics alleviated the toxicity of CuSO in M. aeruginosa, through the downregulation of cation transport proteins and the upregulation of proteins related with chlorophyll a synthesis, photosynthesis, gene expression and oxidation-reduction. Mixed antibiotics also promoted microcystin synthesis in CuSO treated cells through the upregulation of microcystin synthetases. Mixed antibiotics significantly (p < 0.05) increased cell density, growth rate, F/F value, chlorophyll a content and microcystin production ability in CuSO treated cells at test concentrations of 80 and 200 ng L. A no-impact threshold of 20 ng L for mixed antibiotics (5 ng L for each antibiotic) was suggested for eliminating the interference of antibiotic contaminants on cyanobacterial bloom control.
This article was published in the following journal.
Name: Aquatic toxicology (Amsterdam, Netherlands)
Antibiotic contaminants exert stimulatory hormetic effects in cyanobacteria at low (ng L) concentrations, which may interfere with the control of cyanobacterial bloom in aquatic environments exhibitin...
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