Finding the vulnerable checkpoint.

08:00 EDT 20th March 2020 | BioPortfolio

Summary of "Finding the vulnerable checkpoint."

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Name: Nature reviews. Immunology
ISSN: 1474-1741


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Medical and Biotech [MESH] Definitions

A serine/threonine-specific protein kinase which is encoded by the CHEK1 gene in humans. Checkpoint kinase 1 (also known as Chk1) coordinates DNA damage response and cell cycle checkpoint response. Under these conditions, activation of Chk1 results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death, to prevent damaged cells from progressing through the cell cycle.

Groups of persons whose range of options is severely limited, who are frequently subjected to COERCION in their DECISION MAKING, or who may be compromised in their ability to give INFORMED CONSENT.

A nonspecific term referring both to the pathologic finding of swelling of distal portions of axons in the brain and to disorders which feature this finding. Neuroaxonal dystrophy is seen in various genetic diseases, vitamin deficiencies, and aging. Infantile neuroaxonal dystrophy is an autosomal recessive disease characterized by arrested psychomotor development at 6 months to 2 years of age, ataxia, brain stem dysfunction, and quadriparesis. Juvenile and adult forms also occur. Pathologic findings include brain atrophy and widespread accumulation of axonal spheroids throughout the neuroaxis, peripheral nerves, and dental pulp. (From Davis & Robertson, Textbook of Neuropathology, 2nd ed, p927)

Providers that by mandate or mission organize and deliver a significant level of health care and other health-related services to the uninsured, Medicaid recipients, and other vulnerable patients.

A genus comprised of spinner, spotted, and striped DOLPHINS, in the family Delphinidae. Schools of Stenella, that may number in the thousands, often associate with schools of TUNA, and are thus vulnerable to accidental harvesting.

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