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Role of Cholesterol on Binding of Amyloid Fibrils to Lipid Bilayers.

08:00 EDT 24th March 2020 | BioPortfolio

Summary of "Role of Cholesterol on Binding of Amyloid Fibrils to Lipid Bilayers."

Molecular dynamics simulations are used to provide insights into the molecular mechanisms accounting for binding of amyloid fibrils to lipid bilayers and study the effect of cholesterol in this process. We show that electrostatic interactions play an important role in fibril-bilayer binding and cholesterol modulates this interaction. In particular, the interaction between positive residues and lipid head groups becomes more favorable in the presence of cholesterol. Consistent with experiments, we find that cholesterol enhances fibril-membrane binding.

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This article was published in the following journal.

Name: The journal of physical chemistry. B
ISSN: 1520-5207
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