Paramagnetic Organocobalt Capsule Revealing Xenon Host-Guest Chemistry.

08:00 EDT 24th March 2020 | BioPortfolio

Summary of "Paramagnetic Organocobalt Capsule Revealing Xenon Host-Guest Chemistry."

We investigated Xe binding in a previously reported paramagnetic metal-organic tetrahedral capsule, [CoL], where L = 4,4'-bis[(2-pyridinylmethylene)amino][1,1'-biphenyl]-2,2'-disulfonate. The Xe-inclusion complex, [XeCoL], was confirmed by H NMR spectroscopy to be the dominant species in aqueous solution saturated with Xe gas. The measured Xe dissociation rate in [XeCoL], = 4.45(5) × 10 s, was at least 40 times greater than that in the analogous [XeFeL] complex, highlighting the capability of metal-ligand interactions to tune the capsule size and guest permeability. The rapid exchange of Xe nuclei in [XeCoL] produced significant hyperpolarized Xe chemical exchange saturation transfer (hyper-CEST) NMR signal at 298 K, detected at a concentration of [XeCoL] as low as 100 pM, with presaturation at -89 ppm, which was referenced to solvated Xe in HO. The saturation offset was highly temperature-dependent with a slope of -0.41(3) ppm/K, which is attributed to hyperfine interactions between the encapsulated Xe nucleus and electron spins on the four Co centers. As such, [XeCoL] represents the first example of a paramagnetic hyper-CEST (paraHYPERCEST) sensor. Remarkably, the hyper-CEST Xe NMR resonance for [XeCoL] (δ = -89 ppm) was shifted 105 ppm upfield from the diamagnetic analogue [XeFeL] (δ = +16 ppm). The Xe inclusion complex was further characterized in the crystal structure of (C(NH))[XeCoL]·75 HO (). Hydrogen bonding between capsule-linker sulfonate groups and exogenous guanidinium cations, (C(NH)), stabilized capsule-capsule interactions in the solid state and also assisted in trapping a Xe atom (∼42 Å) in the large (135 Å) cavity of . Magnetic susceptibility measurements confirmed the presence of four noninteracting, magnetically anisotropic high-spin Co centers in . Furthermore, [CoL] was found to be stable toward aggregation and oxidation, and the CEST performance of [XeCoL] was unaffected by biological macromolecules in HO. These results recommend metal-organic capsules for fundamental investigations of Xe host-guest chemistry as well as applications with highly sensitive Xe-based sensors.


Journal Details

This article was published in the following journal.

Name: Inorganic chemistry
ISSN: 1520-510X


DeepDyve research library

PubMed Articles [10558 Associated PubMed Articles listed on BioPortfolio]

Self-Assembly of Colloidal Molecules based on Host-Guest Chemistry and Geometric Constraints.

The preparation of colloidal molecules, i.e. clusters of colloids with a defined aggregation number and configuration, is of continued and significant interest in colloid chemistry and materials scien...

Host-Guest Induced Electron Transfer Triggers Radical-Cation Catalysis.

Modifying the reactivity of substrates by encapsulation is a fundamental principle of capsule catalysis. Here we show an alternative strategy, wherein catalytic activation of otherwise inactive quinon...

Synthesis and high pressure studies of white luminescence host-guest complex nanocrystals based on C60 and p-But-calix8arene.

A host-guest structured nanocrystals consisted of p-But-calix[8]arene and fullerene C60 was fabricated with a facial solution deposition method. The as-prepared host-guest complex nanocrystals are wel...

Regulated single-axis rotations of a carbonaceous guest in a van der Waals complex with an entropy cost.

In a tight host-guest complex assembled solely by nondirectional van der Waals forces, unique motions of the guest, such as solid-state inertial rotations, emerge. The regulation of dynamic motions is...

Size-Exclusion Mechanism Driving Host-Guest Interactions between Octahedral Rhenium Clusters and Cyclodextrins.

In aqueous solution, cyclodextrins (CDs) are able to bind strongly either hydrophobic species or also hydrophilic molecules such as octahedral hexametallic cluster. Systematic investigation of the rea...

Clinical Trials [2552 Associated Clinical Trials listed on BioPortfolio]

Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy

Hyper polarized Xenon-129 MRI will be directly compared to a radioactive Xe-133 scintigraphy to detect defects in lung ventilation from airflow limitation. This study is conducted as a pil...

Depth of Hypnosis and Postoperative Nausea and Vomiting During Xenon Anaesthesia

The purpose of this study is ad 1) to measure the depth of hypnosis as assessed by BIS and cAAI during an average general anesthesia with xenon or sevoflurane and to establish a reliable m...

The Clinic Trial On Protection Of Xenon Anaesthesia Against Perioperative Acute Lung Injury For Standford A Acute Aortic Dissection

Acute lung injury (ALI) is the vital complication of Stanford type A aortic dissection. It is confirmed that Xenon has the significant protective effect on important organs and has no supp...

Influence on Erythropoetin-level by Xenon

The purpose of this study is to analyze the effect of xenon-inhalation on erythropoetin-level in blood of healthy volunteers and to determine the efficient time of inhalation. Hypot...

Influence of Xenon Anaesthesia on Transpulmonary Pressure and Tidal Volume Distribution

The influence of xenon anaesthesia on transpulmonary pressure and tidal volume distribution will be investigated in a prospective cohort study in 10 patients of normal weight and 10 obese ...

Medical and Biotech [MESH] Definitions

Stable xenon atoms that have the same atomic number as the element xenon, but differ in atomic weight. Xe-124, 126, 128-131, 134, and 136 are stable xenon isotopes.

Unstable isotopes of xenon that decay or disintegrate emitting radiation. Xe atoms with atomic weights 121-123, 125, 127, 133, 135, 137-145 are radioactive xenon isotopes.

Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.

Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.

Field of chemistry pertaining to the study of inorganic compounds or ions and their interactions with biological ligands at the molecular level.

Quick Search

DeepDyve research library

Relevant Topic

Biological Therapy
Biological therapy involves the use of living organisms, substances derived from living organisms, or laboratory-produced versions of such substances to treat disease. Some biological therapies for cancer use vaccines or bacteria to stimulate the body&rs...

Searches Linking to this Article