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Early diagnosis of Alzheimer's disease in blood using a disposable electrochemical microfluidic platform.

08:00 EDT 24th March 2020 | BioPortfolio

Summary of "Early diagnosis of Alzheimer's disease in blood using a disposable electrochemical microfluidic platform."

Alzheimer's disease (AD) is a neurodegenerative condition that affects a large number of elderly people worldwide and has a high social and economic impact. The diagnosis of AD in its early stage can significantly improve the patients' quali-ty of life. We report the use of A Disintegrin And Metalloprotease 10 (ADAM10) as a blood biomarker for the early diag-nosis of AD. A simple, low-cost, sensitive, and disposable microfluidic platform (DµP) was developed for ADAM10 detec-tion in plasma and cerebrospinal fluid (CSF) based on electrochemical immunosensors. The assay was designed to accu-rately detect ADAM10 in serum, with a limit of detection of 0.35 fg/mL. ADAM10 was detected in subjects divided into cognitively healthy subjects, subjects with mild cognitive impairment (MCI), and AD patients in different disease stages. An increase in protein levels was found throughout the disease, and good DµP accuracy in differentiating individuals was observed. The DµP provided significantly better sensitivity than the well-established enzyme-linked immunosorbent as-say (ELISA) test. ADAM10 and its detection using the DµP was proven to be an alternative tool for the early diagnosis and monitoring of AD, bringing new exciting possibilities to the ability to improve the quality of life of AD patients.

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This article was published in the following journal.

Name: ACS sensors
ISSN: 2379-3694
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