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Metformin protects rotenone-induced dopaminergic neurodegeneration by reducing lipid peroxidation.

08:00 EDT 23rd March 2020 | BioPortfolio

Summary of "Metformin protects rotenone-induced dopaminergic neurodegeneration by reducing lipid peroxidation."

Metformin, a widely prescribed antidiabetic drug, has been suggested to have a neuroprotective effect on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in mice. In this study, we investigated the neuroprotective potential of metformin against rotenone-induced dopaminergic neuron damage and its underlying mechanisms.

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Name: Pharmacological reports : PR
ISSN: 1734-1140
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Medical and Biotech [MESH] Definitions

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