CXCL-10: a new candidate for melanoma therapy?

08:00 EDT 23rd March 2020 | BioPortfolio

Summary of "CXCL-10: a new candidate for melanoma therapy?"

Melanoma is a malignancy that stems from melanocytes and is defined as the most dangerous skin malignancy in terms of metastasis and mortality rates. CXC motif chemokine 10 (CXCL10), also known as interferon gamma-induced protein-10 (IP-10), is a small cytokine-like protein secreted by a wide variety of cell types. CXCL10 is a ligand of the CXC chemokine receptor-3 (CXCR3) and is predominantly expressed by T helper cells (Th cells), cytotoxic T lymphocytes (CTLs), dendritic cells, macrophages, natural killer cells (NKs), as well as some epithelial and cancer cells. Similar to other chemokines, CXCL10 plays a role in immunomodulation, inflammation, hematopoiesis, chemotaxis and leukocyte trafficking.


Journal Details

This article was published in the following journal.

Name: Cellular oncology (Dordrecht)
ISSN: 2211-3436


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