Design and evaluation of biological gate circuits and their therapeutic applications in a model of multidrug resistant cancers.

08:00 EDT 23rd March 2020 | BioPortfolio

Summary of "Design and evaluation of biological gate circuits and their therapeutic applications in a model of multidrug resistant cancers."

Synthetic biology is primarily an emerging research field that consists of designing new synthetic gene circuits dedicated to targeted functions and therapies such as cancer therapy. In this study, a genetic logic NOT-IF gate is used to reduce the multidrug resistance and facilitate the malignant cancer therapy. MCF7 cancer cells were cultured in RPMI-1640 medium and transfected with lentiviral vectors including MDR1 gene and the corresponding shRNA against MDR1 with controllable promoters. Transcript levels and protein levels of MDR1 gene were quantified.


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This article was published in the following journal.

Name: Biotechnology letters
ISSN: 1573-6776


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