Topics

Design and evaluation of biological gate circuits and their therapeutic applications in a model of multidrug resistant cancers.

08:00 EDT 23rd March 2020 | BioPortfolio

Summary of "Design and evaluation of biological gate circuits and their therapeutic applications in a model of multidrug resistant cancers."

Synthetic biology is primarily an emerging research field that consists of designing new synthetic gene circuits dedicated to targeted functions and therapies such as cancer therapy. In this study, a genetic logic NOT-IF gate is used to reduce the multidrug resistance and facilitate the malignant cancer therapy. MCF7 cancer cells were cultured in RPMI-1640 medium and transfected with lentiviral vectors including MDR1 gene and the corresponding shRNA against MDR1 with controllable promoters. Transcript levels and protein levels of MDR1 gene were quantified.

Affiliation

Journal Details

This article was published in the following journal.

Name: Biotechnology letters
ISSN: 1573-6776
Pages:

Links

DeepDyve research library

PubMed Articles [25260 Associated PubMed Articles listed on BioPortfolio]

Modular Analysis and Design of Biological Circuits.

Modularity has been the subject of intense investigation in systems biology for more than two decades. Whether modularity holds in biological networks is a question that has attracted renewed attentio...

Daisy Chain Topology based mammalian synthetic circuits for RNA-only delivery.

Owing to the superiority in safety, RNA-only delivery synthetic circuit is more suitable for cell-based medicine. Modules which possess matching inputs and outputs could be stringed by daisy-chaining ...

Gate Quantum Capacitance Effects in Nanoscale Transistors.

As the physical dimensions of a transistor gate continue to shrink to a few atoms, performance can be increasingly determined by the limited electronic density of states (DOS) in the gate and the gate...

Biological Assembly of Modular Protein Building Blocks as Sensing, Delivery, and Therapeutic Agents.

Nature has evolved a wide range of strategies to create self-assembled protein nanostructures with structurally defined architectures that serve a myriad of highly specialized biological functions. Wi...

Error metrics determination in functionally approximated circuits using SAT solvers.

Approximate computing is an emerging design paradigm that offers trade-offs between output accuracy and computation efforts by exploiting some applications' intrinsic error resiliency. Computation of ...

Clinical Trials [9239 Associated Clinical Trials listed on BioPortfolio]

Sarcopenia in Older Patients in the Acute Hospital Setting

This study will assess whether the use of technology using the Virtual Gate Device (VGD) will prevent or minimize the development of hospital acquired Sarcopenia resulting from Immobilizat...

Study to Compare Standard Perimetry With the New Scotoma-Oriented Perimetry (SCOPE) Using a New Fast German Adaptive Threshold Estimation (GATE) in Glaucoma Patients

The purpose of this study is to compare the two psychophysical perimetric techniques regarding progression of the visual field.

Follow Fever to Decide

Body temperature is one of the markers of biological rhythms. The precise determination of the functioning of the biological clock for an individual is essential to understanding his physi...

Endovascular Aneurysm Repair (EVAR) Gate Study

This study will evaluate a randomized comparison of direct versus snare techniques for cannulation of contralateral gate during an endovascular aneurysm repair (EVAR) procedure. This info...

Efficacy of Two Protocols for Applying Fluorine Varnish to Deciduous Teeth

Evidence that the data flow analysis tests, there are still no studies that show the clarity of the protocols of its application, including the interval and execution factors of applicatio...

Medical and Biotech [MESH] Definitions

Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.

A field of biological research combining engineering in the formulation, design, and building (synthesis) of novel biological structures, functions, and systems.

The application of scientific knowledge or technology to the field of radiology. The applications center mostly around x-ray or radioisotopes for diagnostic and therapeutic purposes but the technological applications of any radiation or radiologic procedure is within the scope of radiologic technology.

An organized procedure carried out by a select committee of professionals in evaluating the performance of other professionals in meeting the standards of their specialty. Review by peers is used by editors in the evaluation of articles and other papers submitted for publication. Peer review is used also in the evaluation of grant applications. It is applied also in evaluating the quality of health care provided to patients.

An approach, process, or methodology which emphasizes credible evidence and the best available scientific knowledge, judiciously integrated to achieve the best possible outcomes in structural design. For example, the design of a new OUTPATIENT CLINIC might incorporate a review of published research on outpatient clinic design, decisions on similar past projects, along with interviews with staff and consumers.

Quick Search


DeepDyve research library

Relevant Topics

Biological Therapy
Biological therapy involves the use of living organisms, substances derived from living organisms, or laboratory-produced versions of such substances to treat disease. Some biological therapies for cancer use vaccines or bacteria to stimulate the body&rs...

Bioinformatics
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...

Cancer
  Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...


Searches Linking to this Article