Gaining New Biological and Therapeutic Applications into the Liver with 3D In Vitro Liver Models.

08:00 EDT 23rd March 2020 | BioPortfolio

Summary of "Gaining New Biological and Therapeutic Applications into the Liver with 3D In Vitro Liver Models."

Three-dimensional (3D) cell cultures with architectural and biomechanical properties similar to those of natural tissue have been the focus for generating liver tissue. Microarchitectural organization is believed to be crucial to hepatic function, and 3D cell culture technologies have enabled the construction of tissue-like microenvironments, thereby leading to remarkable progress in vitro models of human tissue and organs. Recently, to recapitulate the 3D architecture of tissues, spheroids and organoids have become widely accepted as new practical tools for 3D organ modeling. Moreover, the combination of bioengineering approach offers the promise to more accurately model the tissue microenvironment of human organs. Indeed, the employment of sophisticated bioengineered liver models show long-term viability and functional enhancements in biochemical parameters and disease-orient outcome.


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This article was published in the following journal.

Name: Tissue engineering and regenerative medicine
ISSN: 2212-5469


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