Topics

5,6-Dihydro-α-pyrones from the leaves of Cryptocarya pulchinervia (Lauraceae).

08:00 EDT 23rd March 2020 | BioPortfolio

Summary of "5,6-Dihydro-α-pyrones from the leaves of Cryptocarya pulchinervia (Lauraceae)."

Three new 5,6-dihydro-α-pyrones derivatives, named (S)-rugulactone (1) pulchrinervialactone A (2), and pulchrinervialactone B (4), along with one known pyrone, cryptobrachytone C (3), and three known amide derivatives (5-7) have been isolated from the leaves of Cryptocarya pulchrinervia. The structures of 1-7 were elucidated based on extensive spectroscopic data and comparison with literatures. The configurations of compounds 3 and 4 were established by single crystal X-ray diffraction analysis. This is also the first report in finding (S)-rugulactone (1) as a natural product. In addition, the preliminary cytotoxic activity of the isolated compounds was evaluated against P-388 cells using the [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay. All the pyrones, except compound 4, were active significantly inhibiting the growth of P-388 cells, while the amides derivatives (5-7) showed moderate to weak activities. Therefore, compounds 1-3 could be potentially examined further for anticancer agents.

Affiliation

Journal Details

This article was published in the following journal.

Name: Journal of natural medicines
ISSN: 1861-0293
Pages:

Links

DeepDyve research library

PubMed Articles [1084 Associated PubMed Articles listed on BioPortfolio]

Dihydro-β-agarofuran sesquiterpenoid derivatives with anti-inflammatory activity from the leaves of Tripterygium wilfordii.

Triptersinoids A-E (1-5), five undescribed highly oxygenated dihydro-β-agarofuran type sesquiterpenoid polyesters, along with three known analogues were isolated from the aqueous EtOH extracts of the...

Ring-opening formal hetero-5+2 cycloaddition of 1-tosyl-2,3-dihydro-1H-pyrroles with terminal alkynes: entry to 1-tosyl-2,3-dihydro 2,3-dihydro-1H-azepines.

A new Lewis acid catalysed formal hetero-[5+2] cycloaddition of 2,3-dihydro-1H-pyrroles to terminal alkynes is described. By employing a FeCl3 and BF3·OEt2 co-catalytic strategy, the ring-opening of ...

Ocotea complex: A metabolomic analysis of a lauraceae genus.

The genus Ocotea is one of the largest and most economically explored in the Lauraceae family. However, its current industrial use is limited by the difficult identification of Ocotea species. At pres...

Meroterpenoid pyrones, alkaloid and bicyclic brasiliamide from the fungus Neosartorya hiratsukae.

Two new meroterpenoid pyrones, chevalone G (1) and aszonapyrone C (2), a new indole alkaloid, 7-chlorofischerindoline (3) and a new bicyclic brasiliamide, brasiliamide H (4), together with sixteen kno...

Stereospecific Synthesis of 3,4-Dihydro-2H-naphtho-1,4-oxazin-2-ones by Unification of Benzoxepine-4-carboxylates with Chiral Amino Acid Ethyl Esters.

A novel and efficient stereocontrolled method has been developed for the preparation of chiral 3,4-dihydro-2H-naphtho[1,2-b][1,4]oxazin-2-ones by the reaction of benzoxepine-4-carboxylates with chiral...

Clinical Trials [134 Associated Clinical Trials listed on BioPortfolio]

Effectiveness of Khat on Eyelid Wound Healing After Oculoplastic Surgery - a Prospective Study.

The post operative routine after Oculoplastic Surgery includes usage of cold compressions for symptomatic relief and decreasing of the edema and local hematomas in the first few days after...

Use of Maytenus Ilicifolia in the Treatment of Dyspepsia

This study aims to evaluate the therapeutic effect of the infusion of Maytenus ilicifolia Mart. ex Reiss leaves, used for 8 weeks, on patients with dyspepsia. Primary endpoint is SODA scor...

Antibacterial Effect of Guava Leaves Extract Mouthwash Compared to Chlorhexidine Mouthwash in High Caries Risk Patients

This trial is to test the antibacterial effect of Guava leaves extract mouth wash compared to Chlorhexidine mouth wash in high caries risk patients. Also salivary pH and patient satisfact...

Influence of Probenecid and Quinine on the Pharmacokinetics of Azidothymidine

Part I studies the effect of quinine on how zidovudine (AZT) is used by the body and eliminated through the kidneys in HIV infected patients. Part II studies the effect of probenecid and q...

Impact of Dried Moringa Oleifera Leaves in Enhancing Hemoglobin Status

This research project is aimed at combating the nutritional deficiencies (Iron deficiency anemia) of reproductive aged females belonging to the underprivileged group of the society. Since ...

Medical and Biotech [MESH] Definitions

A plant genus of the family LAURACEAE. Members contain cryptofolione, caryachine, grandisin and other compounds. Some PEUMUS species have been reclassified as CRYPTOCARYA.

A plant genus in the LAURACEAE family. Laurus nobilis L. leaves are known for use in SPICES, having a similar flavor as UMBELLULARIA.

A plant genus in the LAURACEAE family. The tree, Umbellularia californica (Hook. & Arn.) Nutt., is known for aromatic leaves used in SPICES having a similar flavor to LAURUS.

Dihydro analog of beta-erythroidine, which is isolated from the seeds and other plant parts of Erythrina sp. Leguminosae. It is an alkaloid with curarimimetic properties.

Keto-pyrans.

Quick Search


DeepDyve research library

Relevant Topics

Radiology
Radiology is the branch of medicine that studies imaging of the body; X-ray (basic, angiography, barium swallows), ultrasound, MRI, CT and PET. These imaging techniques can be used to diagnose, but also to treat a range of conditions, by allowing visuali...

Assays
An assay is an analytic procedure for qualitatively assessing or quantitatively measuring the presence or amount or the functional activity of a target entity.  This can be a drug or biochemical substance or a cell in an organism or organic sample. ...


Searches Linking to this Article