Metabolic Switch in Hepatocellular Carcinoma Patients Treated with Sorafenib: a Proof-of-Concept Trial.

08:00 EDT 23rd March 2020 | BioPortfolio

Summary of "Metabolic Switch in Hepatocellular Carcinoma Patients Treated with Sorafenib: a Proof-of-Concept Trial."

Sorafenib is a multikinase inhibitor used to treat advanced hepatocellular carcinoma (HCC). Recently, a preclinical trial has shown that response to sorafenib is associated with a metabolic shift towards aerobic glycolysis. To test this observation in humans, we decided to conduct a proof-of-concept trial investigating the role of metabolic shift detected on [F]FDG PET/CT in predicting survival and tumor response in HCC patients treated with sorafenib.


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This article was published in the following journal.

Name: Molecular imaging and biology
ISSN: 1860-2002


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