08:00 EDT 23rd March 2020 | BioPortfolio

Summary of "Retinoblastoma."

Retinoblastomas represent 6% of all malignant tumors in children under 5 years old, which untreated lead to blindness in the affected eye and death due to metastases. The main symptoms are leukocoria and strabismus, which if possible, always necessitate a clarification within 1 week for exclusion of a retinoblastoma. The most frequent differential diagnoses are Coats' disease and persistent fetal vasculature (PFV) as well as other intraocular tumors, in particular astrocytomas. Systemic chemotherapy, if necessary in combination with laser hyperthermia, local chemotherapy and brachytherapy are the most important methods for eye-preserving treatment. Advanced cases mostly necessitate enucleation.


Journal Details

This article was published in the following journal.

Name: Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
ISSN: 1433-0423


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PubMed Articles [48 Associated PubMed Articles listed on BioPortfolio]

RNA Sequencing and Bioinformatic Analysis on Retinoblastoma Revealing Cell Cycle Deregulation being a Key Process in Retinoblastoma Tumorigenesis.

Retinoblastoma is a primary pediatric ocular malignancy that could be fatal with inadequate treatment. Whilst multimodal treatments are applied for eye salvage, yet vision loss and metastasis could oc...

Patient knowledge, experiences and preferences regarding retinoblastoma and research: A qualitative study.

We launched a patient engagement strategy to facilitate research involvement of the retinoblastoma (childhood eye cancer) community in Canada. To inform our strategy, we aimed to uncover the experienc...

lncRNA Increases Proliferation and Multidrug Resistance of Retinoblastoma Cells Through Downregulating miR-513a-5p.

Chemoresistance is one of the major obstacles for cancer therapy. Abnormal expression of long noncoding RNAs (lncRNAs) was broadly implicated in chemoresistance of multiple cancers. This study was aim...

Promoting regulated gene diagnosis for retinoblastoma in clinical work.

Retinoblastoma, the most frequent malignant intraocular tumor in childhood, is caused by oncogenic mutations in the RB1 tumor suppressor gene. Identification of these mutations in patients is importan...

Impact of RB1 gene mutation type in retinoblastoma patients on clinical presentation and management outcome.

Retinoblastoma (RB), the most common intraocular malignancy in children, is caused by biallelic inactivation of the human retinoblastoma susceptibility gene (RB1). We are evaluating the impact of the ...

Clinical Trials [51 Associated Clinical Trials listed on BioPortfolio]

Attention to Retinoblastoma Diagnosed in the Trauma Setting

To study the clinical characteristics and treatment outcomes of patients who experienced inadvertent trauma before diagnosis of retinoblastoma.

Studying Health Outcomes After Treatment in Patients With Retinoblastoma

This trial studies health outcomes after treatment in patients with retinoblastoma. Gathering health information over time from patients and family members through vision assessments, samp...

Morphological Analysis of the Pineal Gland in Pediatric Retinoblastoma Patients Using Magnetic Resonance Imaging

MRI is useful for diagnosing pinealoblastoma in retinoblastoma patients

Research on the Environment and Children's Health: Retinoblastoma

The purpose of the research study is to learn more about the causes of retinoblastoma and to identify possible risk factors in the parents of patients with retinoblastoma. This kind of stu...

Retinoblastoma Survivor Study: Assessment of General Health and Quality of Life

The purpose of this study is to find out about the quality of life and health in a group of adults who had retinoblastoma when they were children. By quality of life, we mean how you are f...

Medical and Biotech [MESH] Definitions

Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus E1A protein, the SV40 T antigen, and the human papilloma virus E7 protein.

A ubiquitously expressed regulatory protein that contains a retinoblastoma protein binding domain and an AT-rich interactive domain. The protein may play a role in recruiting HISTONE DEACETYLASES to the site of RETINOBLASTOMA PROTEIN-containing transcriptional repressor complexes.

A retinoblastoma-binding protein that is involved in CHROMATIN REMODELING, histone deacetylation, and transcription repression. Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 where it plays a role in the deposition of NUCLEOSOMES on newly synthesized DNA.

A retinoblastoma-binding protein that is found as a subunit of protein complexes involved in the acetylation of newly synthesized histones. Although initially discovered as a retinoblastoma binding protein, it also has an affinity for core HISTONES and plays a role in recruiting core histone proteins to the active site of the acetyltransferase enzyme complexes.

A retinoblastoma binding protein that is also a member of the Jumonji-domain histone demethylases. It has demethylation activity towards specific LYSINE residues found on HISTONE H3.

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