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Biological Activity of Cerium Dioxide Nanoparticles.

08:00 EDT 24th March 2020 | BioPortfolio

Summary of "Biological Activity of Cerium Dioxide Nanoparticles."

Cerium dioxide nanoparticles (CeO NPs) with a high value of ζ-potential (≥ 30 mV) have been synthesized in reverse microemulsions and they are able to form the high-stable aqueous suspension without any additional stabilizers. It has been shown that the interaction of such CeO NPs with transport proteins, such as BSA, affects their molecular conformation and biochemical activity. The observed changes in the UV-absorbance spectrum and intrinsic fluorescence quenching of BSA molecule are indicative of the occurrence of structural changes caused by binding with the surface of CeO NPs. Low affinity between BSA and CeO NPs has been confirmed by differential scanning calorimetry (DSC). Moreover, CeO NPs can act as regenerative free-radical scavengers, and their antioxidant activity depends on the concentration. The positive charge of CeO NPs can be attributed to their low toxicity towards human malignant lymphocytes MT-4 and breast cancer cells MCF-7 however, the morphofunctional features of MCF-7 cells interacting with CeO NPs are indicative of the decrease in oncogenicity. This article is protected by copyright. All rights reserved.

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This article was published in the following journal.

Name: Journal of biomedical materials research. Part A
ISSN: 1552-4965
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Medical and Biotech [MESH] Definitions

Stable cerium atoms that have the same atomic number as the element cerium, but differ in atomic weight. Ce-136, 138, and 142 are stable cerium isotopes.

Unstable isotopes of cerium that decay or disintegrate emitting radiation. Ce atoms with atomic weights 132-135, 137, 139, and 141-148 are radioactive cerium isotopes.

A layer of protein coating adsorbed by NANOPARTICLES upon entry into PLASMA or other protein-containing biological fluids, which affects how nanoparticles are internalized by cells and cleared from the body.

Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.

An element of the rare earth family of metals. It has the atomic symbol Ce, atomic number 58, and atomic weight 140.12. Cerium is a malleable metal used in industrial applications.

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