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Mechanistic investigation of photochemical reactions by mass spectrometry.

08:00 EDT 24th March 2020 | BioPortfolio

Summary of "Mechanistic investigation of photochemical reactions by mass spectrometry."

This Minireview highlights applications of ESI-MS (ElectroSpray Ionization Mass Spectrometry) for investigations of photochemical reactions. We show possible approaches to on-line ESI-MS monitoring of photocatalytic reactions and give examples of characterization of short-lived photochemical intermediates by ion spectroscopy. The minireview also exemplifies in-depth mass spectrometric studies of photoisomerization reactions and photofragmentation reactions. Apart from mechanistic studies, the coupling of photochemistry and mass spectrometry is a powerful approach in studying structure and properties of biomolecules. We show several examples focused on investigation of intrinsic properties of model biomolecules.

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This article was published in the following journal.

Name: Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
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Medical and Biotech [MESH] Definitions

A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.

A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.

An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.

A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.

Chemical reactions effected by light.

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