Topics

Alzheimer's disease diagnosis from diffusion tensor images using convolutional neural networks.

08:00 EDT 24th March 2020 | BioPortfolio

Summary of "Alzheimer's disease diagnosis from diffusion tensor images using convolutional neural networks."

Machine learning algorithms are currently being implemented in an escalating manner to classify and/or predict the onset of some neurodegenerative diseases; including Alzheimer's Disease (AD); this could be attributed to the fact of the abundance of data and powerful computers. The objective of this work was to deliver a robust classification system for AD and Mild Cognitive Impairment (MCI) against healthy controls (HC) in a low-cost network in terms of shallow architecture and processing. In this study, the dataset included was downloaded from the Alzheimer's disease neuroimaging initiative (ADNI). The classification methodology implemented was the convolutional neural network (CNN), where the diffusion maps, and gray-matter (GM) volumes were the input images. The number of scans included was 185, 106, and 115 for HC, MCI and AD respectively. Ten-fold cross-validation scheme was adopted and the stacked mean diffusivity (MD) and GM volume produced an AUC of 0.94 and 0.84, an accuracy of 93.5% and 79.6%, a sensitivity of 92.5% and 62.7%, and a specificity of 93.9% and 89% for AD/HC and MCI/HC classification respectively. This work elucidates the impact of incorporating data from different imaging modalities; i.e. structural Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI), where deep learning was employed for the aim of classification. To the best of our knowledge, this is the first study assessing the impact of having more than one scan per subject and propose the proper maneuver to confirm the robustness of the system. The results were competitive among the existing literature, which paves the way for improving medications that could slow down the progress of the AD or prevent it.

Affiliation

Journal Details

This article was published in the following journal.

Name: PloS one
ISSN: 1932-6203
Pages: e0230409

Links

DeepDyve research library

PubMed Articles [24691 Associated PubMed Articles listed on BioPortfolio]

Fractional Anisotropy changes in Parahippocampal Cingulum due to Alzheimer's Disease.

Current treatments for Alzheimer's disease are only symptomatic and limited to reduce the progression rate of the mental deterioration. Mild Cognitive Impairment, a transitional stage in which the pat...

Novel atlas of fiber directions built from ex-vivo diffusion tensor images of porcine hearts.

Cardiac MR image-based predictive models integrating statistical atlases of heart anatomy and fiber orientations can aid in better diagnosis of cardiovascular disease, a major cause of death worldwide...

MR biomarkers of degenerative brain disorders derived from diffusion imaging.

The incidence of neurodegenerative diseases has shown an increasing trend. These conditions typically cause progressive functional disability. Identification of robust biomarkers of neurodegenerative ...

HIPPOCAMPAL ATROPHY BASED ALZHEIMER'S DISEASE DIAGNOSIS VIA MACHINE LEARNING METHODS.

Alzheimer's disease is the most common form of dementia and is a serious health problem. The disease is expected to increase further in the upcoming years with the increase of the elderly population. ...

Multimodal analysis using CPiB-PET/MRI for functional evaluation of patients with Alzheimer's disease.

Multimodal PET/MRI image data simultaneously obtained from patients with early-stage of Alzheimer's disease (eAD) were assessed in order to observe pathophysiologic and functional changes, as well as ...

Clinical Trials [9828 Associated Clinical Trials listed on BioPortfolio]

Diffusion Tensor Breast MRI (DTI)

The breast MRI is used in the preoperative scenario to evaluate the extension of a newly diagnosed breast cancer and to screen the contralateral breast. The scan consists of a series of im...

MRS and DTI of White Matter in Alzheimer's Disease

The white matter change of the Alzheimer's disease could be studied by diffusion tensor image and MR spectroscopy to see the microstructral and biochemical change.

Diffusion Tensor Imaging in Predicting Development of Chemotherapy Induced Peripheral Neuropathy in Patients With Breast Cancer (CIPN)

This pilot early phase I trial studies how well diffusion tensor imaging works in predicting development of chemotherapy induced peripheral neuropathy in patients with breast cancer. Diffu...

Diffusion Tensor Imaging (DTI) in Infants With Krabbe Disease

This study is designed to learn about early brain development in children with Krabbe disease, and to use diffusion tensor imaging as an early diagnostic tool to identify newborns at risk ...

Diffusion Tensor Imaging in Chronic Inflammatory Demyelinating Polyneuropathy (PIDC)

The main purpose of this study is to assess the clinical feasibility of diffusion tensor imaging (DTI) for the diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)...

Medical and Biotech [MESH] Definitions

The use of diffusion ANISOTROPY data from diffusion magnetic resonance imaging results to construct images based on the direction of the faster diffusing molecules.

Methods developed to aid in the interpretation of ultrasound, radiographic images, etc., for diagnosis of disease.

A diagnostic technique that incorporates the measurement of molecular diffusion (such as water or metabolites) for tissue assessment by MRI. The degree of molecular movement can be measured by changes of apparent diffusion coefficient (ADC) with time, as reflected by tissue microstructure. Diffusion MRI has been used to study BRAIN ISCHEMIA and tumor response to treatment.

Abnormal structures located chiefly in distal dendrites and, along with NEUROFIBRILLARY TANGLES and SENILE PLAQUES, constitute the three morphological hallmarks of ALZHEIMER DISEASE. Neuropil threads are made up of straight and paired helical filaments which consist of abnormally phosphorylated microtubule-associated tau proteins. It has been suggested that the threads have a major role in the cognitive impairment seen in Alzheimer disease.

Vaccines or candidate vaccines used to prevent or treat ALZHEIMER DISEASE.

Quick Search


DeepDyve research library

Relevant Topic

Neurology - Central Nervous System (CNS)
Alzheimer's Disease Anesthesia Anxiety Disorders Autism Bipolar Disorders Dementia Epilepsy Multiple Sclerosis (MS) Neurology Pain Parkinson's Disease Sleep Disorders Neurology is the branch of me...


Searches Linking to this Article