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Fast Dissolving/Disintegrating Dosage Forms of Natural Active Compounds and Alternative Medicines.

08:00 EDT 24th March 2020 | BioPortfolio

Summary of "Fast Dissolving/Disintegrating Dosage Forms of Natural Active Compounds and Alternative Medicines."

Fast Dissolving/Disintegrating Dosage Forms (FDDFs) are a group of dosage forms which dissolve/disintegrate quickly leading to fast distribution of active ingredient at site of administration thereby provides ease of oral ingestion of solid unit dosage forms and have the potential to enhance transmucosal absorption. Objective of this review is to explore the application of various FDDFs to deliver extracts, herbal powders, natural active compounds and nutraceuticals. Scholarly literature from Pubmed, google scholar and directory of open access journals was retrieved. Patent search for US patent database, WIPO's Patentscope, Espacenet and google patents was performed. Collected literature was screened and only such researches/inventions involving use of FDDFs for delivery of herbal actives and natural active compounds are reported. With time, the use of FDDFs in alternative systems has significantly increased. Homeopathic system and traditional Chinese medicine have embraced FDDFs for delivery of active compounds. Most of the patents in this area are originating from China or by the Chinese innovators. In Europe and US, FDDFs have been extensively studied for delivery of natural active compounds. It was fascinating to know that some new dosage forms and new routes of delivering active compounds are also making their way to the family of FDDFs. Dose of active compound, size of dosage forms. Standardization of extracts, polyherbal mixtures, stability of active compounds, safety, efficacy and pharmacokinetics are challenging issues for developing FDDF herbal formulations or phytopharmaceuticals.

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Name: Recent patents on drug delivery & formulation
ISSN: 2212-4039
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Medical and Biotech [MESH] Definitions

Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.

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Genetic mechanisms that allow GENES to be expressed at a similar level irrespective of their GENE DOSAGE. This term is usually used in discussing genes that lie on the SEX CHROMOSOMES. Because the sex chromosomes are only partially homologous, there is a different copy number, i.e., dosage, of these genes in males vs. females. In DROSOPHILA, dosage compensation is accomplished by hypertranscription of genes located on the X CHROMOSOME. In mammals, dosage compensation of X chromosome genes is accomplished by random X CHROMOSOME INACTIVATION of one of the two X chromosomes in the female.

Release of drugs from DOSAGE FORMS into solution.

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