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Mesenchymal stem cells differentiation: Mitochondria matter in osteogenesis or adipogenesis direction.

08:00 EDT 24th March 2020 | BioPortfolio

Summary of "Mesenchymal stem cells differentiation: Mitochondria matter in osteogenesis or adipogenesis direction."

Mesenchymal stem cells (MSCs) have exhibited enormous therapeutic potential because of their indispensable regenerative, reparative, angiogenic, anti-apoptotic, and immunosuppressive properties. MSCs can best differentiate into mesodermal cell lineages including osteoblasts, adipocytes, muscle cells, endothelial cells and chondrocytes. Specific differentiation of MSCs could be induced through limited conditions. In addition to the relevant differentiation factors, drastic changes also occur in microenvironment to conduct it in an optimal manner for particular differentiation. Recent evidence suggests that the behavior of mitochondria participates in the regulating on direction and process of MSCs differentiation. Therefore, our current review focuses on how the behavior of mitochondria participates in both osteogenesis and adipogenesis of MSC differentiation. Besides that, in our current review, we try to provide an further understanding of the relationship between the behavior of mitochondria and the direction of MSC differentiation, which could optimize current cellular culturing protocols for benefit further tissue engineering by adjusting specific conditions of stem cells.

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This article was published in the following journal.

Name: Current stem cell research & therapy
ISSN: 2212-3946
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Medical and Biotech [MESH] Definitions

Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.

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The malignant stem cells of TERATOCARCINOMAS, which resemble pluripotent stem cells of the BLASTOCYST INNER CELL MASS. The EC cells can be grown in vitro, and experimentally induced to differentiate. They are used as a model system for studying early embryonic cell differentiation.

Cells that can develop into distinct mesenchymal tissue such as BONE; TENDONS; MUSCLES; ADIPOSE TISSUE; CARTILAGE; NERVE TISSUE; and BLOOD and BLOOD VESSELS.

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