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C-H Sulfonylation via 1,3-Rearrangement of Sulfonyl Group in N-protected 3-Bissulfonimidoindole Derivatives Using Fluorine Reagent.

08:00 EDT 24th March 2020 | BioPortfolio

Summary of "C-H Sulfonylation via 1,3-Rearrangement of Sulfonyl Group in N-protected 3-Bissulfonimidoindole Derivatives Using Fluorine Reagent."

A C-H sulfonylation of N-protected 3-bissulfonimidoindole derivatives via a 1,3-rearrangement of a sulfonyl group on a bissulfonimide moiety using tetra-n-butylammonium fluoride (TBAF) was developed to provide 2-sulfonyl-3-sulfonamidoindole derivatives in high yields as a novel Csp2-H functionalization of heterocycles. The rearrangement of the sulfonyl group proceeded through an intermolecular addition of the desorbed sulfinyl ion from the bissulfonimide moiety in the substrate.

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This article was published in the following journal.

Name: The Journal of organic chemistry
ISSN: 1520-6904
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