Inorganic and Metal-Organic Nanocomposites for Cascade-Responsive Imaging and Photochemical Synergistic Effects.

08:00 EDT 24th March 2020 | BioPortfolio

Summary of "Inorganic and Metal-Organic Nanocomposites for Cascade-Responsive Imaging and Photochemical Synergistic Effects."

Porphyrins coordinated with platinum(II) chemotherapeutic drugs are attractive for the development of photosensitizers for photodynamic therapy (PDT) of cancer. In this paper, inorganic and metal-organic nanocomposites were synthesized with cascade-responsive imaging and photochemical synergistic effects. After endo/lysosomal escape, the outer metal-organic frameworks were degraded, leading to the release of an excellent photosensitizer (tetrapyridylporphyrin, PtTPyP). Subsequently, doxorubicin (DOX), inserted in the adenosine triphosphate (ATP) aptamer-functionalized gold nanoparticles, was released under the stimulation of endogenous ATP, synergistically enhancing cancer treatment. Fluorescence imaging allowed tracking of PtTPyP and DOX for real-time detection and on-demand therapy. This strategy endowed the nanocomposites with stability, responsiveness, effectiveness, and ease of synthesis, namely, sTREE strategy. Accordingly, our demonstration provided a promising and smart nanocarrier for imaging and drug delivery.


Journal Details

This article was published in the following journal.

Name: Inorganic chemistry
ISSN: 1520-510X


DeepDyve research library

PubMed Articles [16200 Associated PubMed Articles listed on BioPortfolio]

Multi-functional metal-organic framework and metal-organic framework-zeolite nanocomposite for the synthesis of carbohydrate derived chemicals via one-pot cascade reaction.

Zeolite-metal organic framework nanocomposite catalyst is developed for the synthesis of 2-((5-(hydroxymethyl)furan-2-yl)methylene)malononitrile from sucrose/fructose/glucose via one-pot cascade proto...

Target-Driven Cascade-Amplified Release of Loads from DNA-Gated Metal-Organic Frameworks for Electrochemical Detection of Cancer Biomarker.

In this paper, a label-free and stimuli-responsive electrochemical biosensing platform was fabricated based on target-driven loads release from DNA-gated metal-organic frameworks (MOFs) with cascade a...

Photochemical behaviors of mercury (Hg) species in aquatic systems: A systematic review on reaction process, mechanism, and influencing factor.

The fate and transport of Hg species in natural aquatic environment are strongly affected by photochemical transformation of Hg, Hg, and MeHg. Migration of Hg is determined by its complexation with or...

Metal-Organic Framework Magnets.

Metal-organic frameworks represent the ultimate chemical platform on which to develop a new generation of designer magnets. In contrast to the inorganic solids that have dominated permanent magnet tec...

Organic-inorganic nanoflowers: from design strategy to biomedical applications.

Organic-inorganic hybrid nanoflowers (NF) with sizes or features on a nanoscale are a class of flower-shaped nanomaterials self-assembled from metal ions and organic components. Here, to be more speci...

Clinical Trials [5321 Associated Clinical Trials listed on BioPortfolio]

A Phase I Trial of ZIO-101 in Hematologic Cancers

This study uses a new investigational (not yet approved by the FDA for widespread use) drug called ZIO-101, an organic arsenical. You must be diagnosed to have relapsed/refractory leukemia...

Immediate Implant Placement in the Esthetic Zone With and Without Using Autogenous Mixed With Xenograft

Xenografts are graft materials derived from the inorganic portion of animal bones; the most common source is bovine the removal of the organic component are processed to remove their antig...

Sinus Lift With Newly Forming Bone and Inorganic Bovine Bone

The aim of this study is to evaluate the efficacy of newly forming bone graft (NFB) in the gain of bone volume in sinus lift procedures. For that, it will be compared the tomographic bone ...

Metal Ion Release From an FDA-Approved Metal-on-Metal Total Hip Replacement Implant

This is a multi-center, randomized study to compare blood and urine cobalt, chromium, and titanium ion levels of a metal-on-metal articular bearing coupled with two different head sizes to...

A Multicentre Trial to Compare Two Articulating Bearing Surfaces as Used in Cementless Primary Hip Arthroplasty

The aim of this study is to demonstrate the non-inferiority of the ceramic-on-metal articulation using large diameter bearings (38mm to 60mm) compared to the metal on metal articulation us...

Medical and Biotech [MESH] Definitions

Inorganic derivatives of ammonia by substitution of one or more hydrogen atoms with chlorine atoms or organic compounds with the general formulas R2NCl and RNCl2 (where R is an organic group).

Compounds derived from organic or inorganic acids in which at least one hydroxyl group is replaced by an –O-alkyl or other organic group. They can be represented by the structure formula RCOOR’ and are usually formed by the reaction between an acid and an alcohol with elimination of water.

The use of molecularly targeted imaging probes to localize and/or monitor biochemical and cellular processes via various imaging modalities that include RADIONUCLIDE IMAGING; ULTRASONOGRAPHY; MAGNETIC RESONANCE IMAGING; fluorescence imaging; and MICROSCOPY.

Supramolecular networks that consist of ordered arrangements of organic electron donor linkers (usually ditopic or polytopic organic carboxylates) and metal cations. They can have an extremely high surface area and adjustable pore size that allows for the insertion of other molecules capable of various functions such as catalysis, capture of carbon dioxide, and drug delivery.

Organic compounds that contain technetium as an integral part of the molecule. These compounds are often used as radionuclide imaging agents.

Quick Search

DeepDyve research library

Relevant Topics

Cancer Disease
Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start - for example, cancer that begins in the colon is called colon cancer; cancer th...

  Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...

Drug Delivery
<!--LGfEGNT2Lhm-->Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals.  <!--LGfEGNT2Lhm-->Drug delivery technologies are <!--LGfEGNT2Lhm-->patent pr...

Searches Linking to this Article