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21:46 EDT 17th October 2018 | BioPortfolio

The US National Library of Medicine and National Institutes of Health manage which comprises of more than 21 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.  BioPortfolio aims to publish relevant information on published papers, clinical trials and news associated with users selected topics.

For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.

Showing PubMed Articles 1–25 of 1,000,000+

Clinical efficacy of intrauterine cephapirin benzathine administration on clearance of uterine bacteria and subclinical endometritis in postpartum buffaloes.

This study examined the effect of single IU administration of cephapirin on clinical recovery, clearance of uterine bacteria and reproductive performance of postpartum buffaloes with subclinical endometritis (SCE). Buffaloes (n=86) at 35 days postpartum (DPP) with >10% polymorphonuclear (PMN) cells in endometrial cytosmears were designated as positive (SCEP, n=29) and buffaloes with ≤10% PMN cell were designated as negative (SCEN, n=57) for SCE. Out of 29 positive buffaloes, 15 were administered a single ...

Effects of storage conditions on two platelet agonists for whole blood impedance platelet aggregometry in dogs.

Whole blood impedance platelet aggregometry (Multiplate-) can be performed with different agonists to evaluate platelet function. Although the manufacturer recommends disposal of stored reagents after 1 month at -20°C or 24 hours at 4°C, reagent integrity after reconstitution under different storage conditions is unknown. If reagent integrity is stable for longer periods, assay costs could decrease dramatically.

Police response to individuals displaying suicidal or self-harming behaviours: An integrative review.

Police are increasingly being called upon to respond to people experiencing suicidal crisis. Such incidents are a challenging aspect of modern policing. This paper reports on an integrative review study that aimed to investigate police responses to individuals displaying suicidal or self-harming behaviours. Six electronic databases were searched for peer-reviewed articles published between 2007 and 2017 relating to police responses to individuals in suicidal crisis. The review identified 12 studies that met...

Evaluation of Breast Cancer Morphology Using Diffusion-Weighted and Dynamic Contrast-Enhanced MRI: Intermethod and Interobserver Agreement.

The capability of diffusion-weighted imaging (DWI) for morphological analysis of breast lesions is underexplored.

Reactive and Functional Nanoobject(s) by Polymerization-Induced Self-Assembly.

Polymerization-induced self-assembly (PISA) is becoming a standard technique for generating core-shell polymeric nanoparticles of various morphologies ranging from classic spheres to rods/fibers ("worm-like") and vesicles. After the initial quest for polymerization control in dispersed media, the focus of PISA research has drastically shifted, first to morphological control and now to the introduction of reactivity and functionality in order to generate useful materials. The present review is dedicated to t...

Quantitative Characterization of Carotid Plaque Components Using MR Apparent Diffusion Coefficients and Longitudinal Relaxation Rates at 3T: A Comparison With Histology.

There is limited evidence of parametric MR mapping to characterize carotid plaques associated with cerebral ischemic events.

Diagnostic Fragmentation Filtering for the Discovery of New Chaetoglobosins and Cytochalasins.

Microbial natural products are often biosynthesized as classes of structurally related compounds that have similar MS/MS fragmentation patterns. Mining MS/MS datasets for precursor ions that share diagnostic or common features enables entire chemical classes to be identified, including novel derivatives that have previously been unreported. Analytical data analysis tools that can facilitate a class-targeted approach to rapidly dereplicate known compounds and identify structural variants within complex matri...

Water Vapor Exposure Chamber for Constant Humidity and Hydrogen and Oxygen Stable Isotope Composition.

Water vapor exposure experiments have applications for studying water physisorption and chemisorption hydration and hydroxylation reactions on a wide variety of material surfaces. The stable isotopes of hydrogen and oxygen in the water molecule are a useful tracer of water exchange mechanisms and/or rates in such vapor exposure experiments.

Variation in the social organization of gorillas: Life history and socioecological perspectives.

A focus of socioecological research is to understand how ecological, social, and life history factors influence the variability of social organization within and between species. The genus Gorilla exhibits variability in social organization with western gorilla groups being almost exclusively one-male, yet approximately 40% of mountain gorilla groups are multimale. We review five ultimate causes for the variability in social organization within and among gorilla populations: human disturbance, ecological co...

Key factors determining variations in RNAi efficacy mediated by different dsRNA lengths in Tribolium castaneum.

dsRNA length may affect RNAi efficacy. Herein, variation in RNAi efficacy associated with dsRNA molecular length was confirmed via comparison of knockdown results following dsRNA injection into Tribolium castaneum. Through in vitro experiments with T. castaneum midgut, dsRNA accumulation in the midgut, degradation by midgut homogenates, and persistence in hemolymph after injection were tested to determine the causes of RNAi efficacy variation. The comparative efficacies of dsRNAs were 480 bp ≈ 240 bp>120 ...

Platinum-catalyzed Desaturation of Lactams, Ketones and Lactones.

The development of a general platinum-catalyzed desaturation of N-protected lactams, ketones, and lactones to their conjugated α,β-unsaturated counterparts is reported. The reaction is operated under mildly acidic conditions at room temperature or 50 oC. It is scalable and tolerates a wide range of functional groups. The complementary reactivity to the palladium-catalyzed desaturation is demonstrated in the efficient conversion of iodide, bromide and sulfur-containing substrates.

Volunteer involvement in the organisation of palliative care: A survey study of the healthcare system in Flanders and Dutch-speaking Brussels, Belgium.

Ageing populations increasingly face chronic and terminal illnesses, emphasising the importance of palliative care and quality of life for terminally ill people. Facing resource constraints in professional healthcare, some governments expect informal caregivers like volunteers to assume a greater share of care provision. We know volunteers are present in palliative care and perform many roles, ranging from administration to providing companionship. However, we do not know how involved they are in the organi...

Functionally impaired Tfh cells induce regulatory B cells and CD14 HLA-DR cells differentiation in non-small cell lung cancer.

Non-small cell lung cancer (NSCLC) represents one of the most common and aggressive cancers worldwide, as it typically displays irreversible progression and poor prognosis. The interaction between programmed cell death 1 (PD-1) and its ligand, PD-L1, plays important roles in tumor immunology. Follicular helper T (Tfh) cells have characteristically high PD-1 expression; thus, in the present study, we investigated the role of circulating Tfh cells and their correlation with disease-free survival after tumor r...

Challenges and opportunities related to the use of chitosan as food preservative.

Chitosan has attracted a growing attention as food preservative due to its versatility, non-toxicity, biodegradability, and biocompatibility. This review aims to provide a critical appraisal of the limitations and opportunities of the use of chitosan as food preservative. Application of chitosan as food preservatives necessitates insights into mechanisms of chitosan-mediated cell death and injury, factors affecting chitosan activity and effects of chitosan on food safety and quality. Chitosan exert antimicr...

New insights into Citrobacter freundii Sepsis in Neonates.

This study aimed to investigate the clinical features of neonatal sepsis caused by Citrobacter freundii as well as the current status and treatment strategy of multi-drug resistance for infection with this bacterium.

Surgical Treatment of Medication-Related Osteonecrosis of the Upper Jaw: Case Series.

The management of maxillary medication-related osteonecrosis of the jaw (MRONJ) is challenging. Therefore, identifying the proper treatment is important. This study aimed to evaluate the surgical treatment of maxillary MRONJ using single-layer closure with mucoperiosteal flap and double-layer closure with buccal fat pad flap (BFPF) and mucoperiosteal flap and to find the outcomes after rehabilitation with obturators.

Development of lipopolyplexes for gene delivery: A comparison of the effects of differing modes of targeting peptide display on the structure and transfection activities of lipopolyplexes.

The design, synthesis and formulation of non-viral gene delivery vectors is an area of renewed research interest. Amongst the most efficient non-viral gene delivery systems are lipopolyplexes, in which cationic peptides are co-formulated with plasmid DNA and lipids. One advantage of lipopolyplex vectors is that they have the potential to be targeted to specific cell types by attaching peptide targeting ligands on the surface, thus increasing both the transfection efficiency and selectivity for disease targe...

Coordinated regulation of nitrogen fixation and molybdate transport by molybdenum.

Biological nitrogen fixation, the reduction of chemically inert dinitrogen to bioavailable ammonia, is a central process in the global nitrogen cycle highly relevant for life on earth. N reduction to NH is catalyzed by nitrogenases exclusively synthesized by diazotrophic prokaryotes. All diazotrophs have a molybdenum nitrogenase containing the unique iron-molybdenum cofactor FeMoco. In addition, some diazotrophs encode one or two alternative Mo-free nitrogenases that are less efficient at reducing N than Mo...

Evolutionary melting pots and reproductive isolation: A ring-shaped diversification of an odorous frog (Odorrana margaratea) around the Sichuan Basin.

Quaternary climatic oscillations and geography are of primary importance in shaping intraspecific genetic diversity. We examined the diversification patterns and inferred processes for the green odorous frog (Odorrana margaretae) of western China. Species distribution modeling showed that the species has a continuous circular distribution around the Sichuan Basin while the basin itself is largely uninhabitable. Population genetic and phylogenetic analyses revealed that the species has a ring-shaped divergen...

Hysterectomy by Transvaginal Natural Orifice Transluminal Endoscopic Surgery versus laparoscopy as a day-care procedure: a randomised controlled trial.

To compare hysterectomy by Transvaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) versus total laparoscopic hysterectomy (TLH) as a day-care procedure.

Properties of novel surfactin-derived biosurfactants obtained through solid-phase synthesis.

Eight molecules, four peptides (SPs) and four lipopeptides (LPs) derived by rational design from surfactin, a well-known secreted biosurfactant from Bacillus subtilis, were produced employing Fmoc-based solid-phase synthesis. These new peptides were tested to evaluate their potential biosurfactant and biological activities, aiming at possible applications in industrial, biological, pharmaceutical, and medical use. Five molecules (SP1, SP2, SP4, LP5, and LP8) presented potential for medical uses, mainly due ...

Pharmacokinetics of Tenofovir Alafenamide, Tenofovir, and Emtricitabine Following Administration of Coformulated Emtricitabine/Tenofovir Alafenamide in Healthy Japanese Subjects.

A fixed-dose combination of tenofovir alafenamide (TAF) and emtricitabine (FTC) is available in 2 tablet strengths in Japan (FTC/TAF 200/10 mg and FTC/TAF 200/25 mg). These are used once daily in combination with other antiretroviral agents for the treatment of human immunodeficiency virus type 1 infection. The primary objective of this study was to investigate if there is any clinically relevant pharmacokinetic difference for TAF, tenofovir (TFV), and FTC between Japanese and non-Japanese with historical...

Rapid structure determination of microcrystalline molecular compounds using electron diffraction.

Chemists of all fields currently publish about 50,000 crystal structures per year, the vast majority of which are X-ray structures. We determined two molecular structures employing electron- rather than X-ray diffraction. For this purpose an EIGER hybrid pixel detector was fitted to a transmission electron microscope yielding an electron diffractometer. The structure of a new methylene blue derivative was determined at 0.9 Å resolution from a crystal smaller than 1×2 μm². Several thousand active pharmac...

Rapid establishment of a flowering cline in Medicago polymorpha after invasion of North America.

To establish and spread in a new location, an invasive species must be able to carry out its life cycle in novel environmental conditions. A key trait underlying fitness is the shift from vegetative to reproductive growth through floral development. In this study, we used a common garden experiment and genotyping-by-sequencing to test whether the latitudinal flowering cline of the North American invasive plant Medicago polymorpha was translocated from its European native range through multiple introductions...

Tuberous sclerosis complex.

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