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PubMed Journals Articles About "Scientists Take First Step Towards Digital Channels Brain" RSS

05:44 EST 17th November 2019 | BioPortfolio

Scientists Take First Step Towards Digital Channels Brain PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Scientists Take First Step Towards Digital Channels Brain articles that have been published worldwide.

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Showing "Scientists take first step towards digital channels brain" PubMed Articles 1–25 of 14,000+

Loose Coupling Between SK and P/Q-type Ca Channels in Cartwheel Cells of the Dorsal Cochlear Nucleus.

Small-conductance Ca-activated K (SK) and large conductance, voltage- and Ca-activated K (BK) channels are Ca-activated K channels that control action potential firing diverse neurons in the brain. In cartwheel cells of the dorsal cochlear nucleus, blockade of either channel type leads to excessive production of spike bursts. In the same cells, P/Q-type Ca channels in plasma membrane and ryanodine receptors in endoplasmic reticulum supply Ca to BK channels through Ca nanodomain signaling. In this study, vol...


A neural network approach to segment brain blood vessels in digital subtraction angiography.

Cerebrovascular diseases (CVDs) affect a large number of patients and often have devastating outcomes. The hallmarks of CVDs are the abnormalities formed on brain blood vessels, including protrusions, narrows, widening, and bifurcation of the blood vessels. CVDs are often diagnosed by digital subtraction angiography (DSA) yet the interpretation of DSA is challenging as one must carefully examine each brain blood vessel. The objective of this work is to develop a computerized analysis approach for automated ...

A New Recall of Alcohol Marketing Scale for Youth: Measurement Properties and Associations With Youth Drinking Status.

Adolescents are exposed to alcohol marketing through traditional advertising and through newer digital media channels. Cumulative marketing exposure across channels is of concern but has been insufficiently studied. This study explores the measurement of alcohol marketing exposure across channels and whether cumulative recalled exposure is independently associated with underage drinking.


Past, Present, and Future of Brain Organoid Technology.

Brain organoids are an exciting new technology with the potential to significantly change our understanding of the development and disorders of the human brain. With step-by-step differentiation protocols, three-dimensional neural tissues are self-organized from pluripotent stem cells, and recapitulate the major millstones of human brain development in vitro. Recent studies have shown that brain organoids can mimic the spatiotemporal dynamicity of neurogenesis, the formation of regional neural circuitry, an...

Head-to-head comparison of image quality between brain F-FDG images recorded with a fully digital versus a last-generation analog PET camera.

The quality of phantom images was previously shown to be higher on digital (Vereos Philips®) compared to analog PET (Ingenuity Philips®) cameras. This study aimed to determine the extent to which this difference still remains significant on normal brain F-FDG PET images.

Design and Development of the Brain Training System for the Digital "Maintain Your Brain" Dementia Prevention Trial.

Dementia is the leading cause of disability worldwide, and interventions aimed at reducing the prevalence and burden of the disease are urgently needed. Maintain Your Brain (MYB) is a randomized controlled trial of a multimodal digital health intervention targeting modifiable dementia risk factors to combat cognitive decline and potentially prevent dementia. In addition to behavioral modules targeting mood, nutrition, and physical exercise, a new Brain Training System (BTS) will deliver computerized cogniti...

Facile synthesis of Ag-CuO/SBA-15 for aerobic epoxidation of olefins with high activity.

An efficient "structure-property" catalyst Ag-CuO/SBA-15 for aerobic epoxidation of olefins was designed and prepared via simple grinding method, which provides a dynamic assembly driving force to push the precursors into the channels step by step. Partial melting on the precursor particles surface is necessary for synthesizing the Ag-CuO/SBA-15 catalysts. During the thermal grinding process, the melting Cu(NO3)2 first adhered on AgNO3 particles surface which were also in partial melting state, and then the...

Use of the Principles of Design Thinking to Address Limitations of Digital Mental Health Interventions for Youth: Viewpoint.

Numerous reviews and meta-analyses have indicated the enormous potential of technology to improve the appeal, effectiveness, cost, and reach of mental health interventions. However, the promise of digital mental health interventions for youth has not yet been realized. Significant challenges have been repeatedly identified, including engagement, fidelity, and the lack of personalization. We introduce the main tenets of design thinking and explain how they can specifically address these challenges, with an e...

Quantitative assessment of phased array coils with different numbers of receiving channels in terms of signal-to-noise ratio and spatial noise variation in magnetic resonance imaging.

The neuroimaging of humans using 7T magnetic resonance imaging (MRI) has been conducted using phased array (PA) coils with different numbers of receiving channels. PA coils with a high number of channels may offer parallel imaging (PI) with a high reduction (R)-factor, which is enabled via under-sampling and coil geometry (g) factor, increasing the radiofrequency signal sensitivity provided by a small coil. The goals of this study were to assess and validate the coil performance of PA coils with different n...

TRP channels in gastric cancer: New hopes and clinical perspectives.

Gastric cancer is a multifactorial disease associated with a combination of and environmental factors. Each year, one million new gastric cancer cases are diagnosed worldwide and two-thirds end up losing the battle with this devastating disease. Currently, surgery represents the only effective treatment option for patients with early stage tumors. However, the asymptomatic phenotype of this disease during the early stages poses as a significant limiting factor to diagnosis and often renders treatments ineff...

Usefulness of the "two-step method" of digital follow-up in early stage melanoma detection in at high risk French patients - A retrospective 4-year study.

Dermoscopy was proven more accurate than naked-eye examination and sequential digital dermoscopy imaging (SDDI) superior to dermoscopy alone for melanoma detection . SDDI combined with total-body photography (TBP) namely the "two-step method" of digital follow-up (DFU), seems at present the best surveillance strategy for high risk patients. With the aim to endorse its usefulness, we retrospectively studied 148 at high risk patients included in DFU at the Dermato-oncology Unit of Hôpital Saint-Louis between...

Using selfies to challenge public stereotypes of scientists.

In an online Qualtrics panel survey experiment (N = 1620), we found that scientists posting self-portraits ("selfies") to Instagram from the science lab/field were perceived as significantly warmer and more trustworthy, and no less competent, than scientists posting photos of only their work. Participants who viewed scientist selfies, especially posts containing the face of a female scientist, perceived scientists as significantly warmer than did participants who saw science-only images or control images. P...

DNA-based digital comparator systems constructed by multifunctional nanoswitches.

In this paper, we propose a strategy involving coupling DNA structural nanoswitches with toehold mediated strand displacement for constructing novel DNA-based digital comparator (DC) logic systems, which are a basic part of traditional electronic computers and can compare whether two or more input numbers are equal. However, when the number of DC inputs is increased to a certain level, the speed and quality of the computing circuit can be affected because of the limitations of conventional electronic comput...

Beyond the Isolated Brain: The Promise and Challenge of Interacting Minds.

As scientists, we brainstorm and develop experimental designs with our colleagues and students. Paradoxically, this teamwork has produced a field focused nearly exclusively on mapping the brain as if it evolved in isolation. Here, we discuss promises and challenges in advancing our understanding of how human minds connect during social interaction.

Two-view digital breast tomosynthesis versus digital mammography in a population-based breast cancer screening programme (To-Be): a randomised, controlled trial.

Digital breast tomosynthesis is an advancement of mammography, and has the potential to overcome limitations of standard digital mammography. This study aimed to compare first-generation digital breast tomo-synthesis including two-dimensional (2D) synthetic mammograms versus digital mammography in a population-based screening programme.

Brain Tumors Feed Off Healthy Neurons.

Cancer cells in the brain can form synaptic connections with neighboring neuronal cells, according to a trio of recently published studies. When activated, these synapses promote tumor proliferation, survival, and invasiveness. Disrupting the communication channels between neurons and cancer cells could help blunt the growth of deadly gliomas and brain metastases.

Digit Force Controls and Corresponding Brain Activities in Finger Pressing Performance: A Comparison Between Older Adults and Young Individuals.

This study aims toward an investigation and comparison of the digital force control and the brain activities of older adults and young groups during digital pressing tasks. A total of 15 young and 15 older adults were asked to perform force ramp tasks at different force levels with a custom pressing system. Near-infrared spectroscopy was used to collect the brain activities in the prefrontal cortex and primary motor area. The results showed that the force independence and hand function of the older adults w...

Brain tumor disparities: From biology to social determinants - The 2019 Brain Tumor Epidemiology Consortium meeting report.

The Brain Tumor Epidemiology Consortium (BTEC) is an international consortium that fosters international and interdisciplinary collaborations focusing on research related to the etiology, outcomes, and prevention of brain tumors. The 20 annual BTEC meeting with the theme "Brain tumor Disparities: From Biology to Social Determinants" was held in Los Angeles, CA, USA, on June 6 - 8, 2019. Scientists from the United States and Europe representing a broad range of brain tumor research disciplines presented th...

Digital Therapeutics: Emerging New Therapy for Neurologic Deficits after Stroke.

Digital therapeutics is an evidence-based intervention using high-quality software, with the sole purpose of treatment. As many healthcare systems are encountering high demands of quality outcomes, the need for digital therapeutics is gradually increasing in the clinical field. We conducted review of the implications of digital therapeutics in the treatment of neurological deficits for stroke patients. The implications of digital therapeutics have been discussed in four domains: cognition, speech and aphasi...

Recent progress in structural studies on canonical TRP ion channels.

Canonical TRP channels (TRPC) are non-selective cation channels that are involved in various important physiological processes. Currently, the structures of different TRPC ion channel family members are resolved by cryo-EM at resolutions ranging from 2.8 Å to 5.8 Å. These structures reveal the conserved architecture of TRPC ion channels as well as the specific features of each channel subtype. This review focuses on the structural differences in the extracellular portions, transmembrane domains and th...

Pyogenic Brain Abscesses in a Patient With Digital Clubbing.

TRP Channel Reconstitution in Lipid Bilayers.

The family of the transient receptor potential (TRP) proteins presents a diverse group of polymodal ion channels intertwined in the regulation of various physiological processes. Currently, TRP channels are well established in temperature-sensation, thermoregulation, pain sensation, and mineral homeostasis. Furthermore, new evidence suggests that TRP channels are also implicated in hormonal signaling, where the channels are responsible for propagating hormone-induced signals along the neural circuitry and a...

Cell-Specific Neuropharmacology.

Neuronal communication involves a multitude of neurotransmitters and an outstanding diversity of receptors and ion channels. Linking the activity of cell surface receptors and ion channels in defined neural circuits to brain states and behaviors has been a key challenge in neuroscience, since cell targeting is not possible with traditional neuropharmacology. We review here recent technologies that enable the effect of drugs to be restricted to specific cell types, thereby allowing acute manipulation of the ...

Connections Between Amyloid Beta and the Meningeal Lymphatics As a Possible Route for Clearance and Therapeutics.

Alzheimer's disease (AD) is a complex neurodegenerative disorder causing progressive cognitive decline, memory loss, and death of neural tissue. Current research suggests a connection between bulk flow of interstitial fluid and cerebrospinal fluid across the blood-brain barrier and the recently confirmed meningeal lymphatic channels of the brain. The main symptom of interest in AD is the spontaneous aggregation of amyloid beta (Aβ) proteins resulting from increased production or lack of clearance from brai...

Scientific Community Image Forum: A discussion forum for scientific image software.

Forums and email lists play a major role in assisting scientists in using software. Previously, each open-source bioimaging software package had its own distinct forum or email list. Although each provided access to experts from various software teams, this fragmentation resulted in many scientists not knowing where to begin with their projects. Thus, the scientific imaging community lacked a central platform where solutions could be discussed in an open, software-independent manner. In response, we introdu...


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