PubMed Journals Articles About "Bioverativ Taps Manufacturer Steps Biogen Shadow" - Page: 2 RSS

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Showing "Bioverativ taps manufacturer steps Biogen shadow" PubMed Articles 26–50 of 1,600+

Emergency Manual Implementation in a Large Academic Anesthesia Practice: Strategy and Improvement in Performance on Critical Steps.

The use of cognitive aids, such as emergency manuals (EMs), improves team performance on critical steps during crisis events. In our large academic anesthesia practice, we sought to broadly implement an EM and subsequently evaluate team member performance on critical steps.

Data Mining CMMSs: How to Convert Data into Knowledge.

Although the healthcare technology management (HTM) community has decades of accumulated medical device-related maintenance data, little knowledge has been gleaned from these data. Finding and extracting such knowledge requires the use of the well-established, but admittedly somewhat foreign to HTM, application of inferential statistics. This article sought to provide a basic background on inferential statistics and describe a case study of their application, limitations, and proper interpretation. The rese...

Outdoor Shadow Estimating Using Multiclass Geometric Decomposition Based on BLS.

Illumination is a significant component of an image, and illumination estimation of an outdoor scene from given images is still challenging yet it has wide applications. Most of the traditional illumination estimating methods require prior knowledge or fixed objects within the scene, which makes them often limited by the scene of a given image. We propose an optimization approach that integrates the multiclass cues of the image(s) [a main input image and optional auxiliary input image(s)]. First, Sun visibi...

NEV supply chain coordination and sustainability considering sales effort and risk aversion under the CVaR criterion.

In a two-echelon new energy vehicle (NEV) supply chain consisting of a risk-neutral manufacturer and a risk-averse retailer, the coordination and sustainability problem is investigated. The risk-averse retailer, who makes sales effort and undertakes the incurred effort cost, decides the order quantity and sales effort level under the Conditional Value-at-Risk (CVaR) criterion. We derive the optimal centralized decisions of a vertically integrated supply chain where the retailer is owned by the manufacturer....

Implant Testing and the "Strain Energy" Concept.

Benchtop performance test methodologies differ between manufacturers as regulatory agencies often leave the interpretation of testing standards up to manufacturer discretion, resulting in an inability to directly compare implants across manufacturers. Furthermore, traditional benchtop test methodologies focus on mechanical performance standards to address objective endpoints such as shell strength. However, other more difficult to define clinical performance requirements such as softness and natural feel ar...

Evaluation of Skin and Respiratory Symptoms Among Employees with Occupational Exposures to Cobalt and Chromium at an Orthopedic Implant Manufacturer.

Coming of Age in the Shadow of the Taliban: Adolescents' and Parents' Views Toward Interpersonal Violence and Harmful Traditional Practices in Afghanistan.

To understand Afghan adolescents' and parents' attitudes toward interpersonal violence.

Increasing the efficiency of CPP-ACP to remineralize enamel white spot lesions.

To compare the remineralization efficacy of using the MI paste plus according to manufacturer's instructions to MI varnish and to using a modified method of MI-paste plus application.

Validity of wearable activity monitors for tracking steps and estimating energy expenditure during a graded maximal treadmill test.

The purpose of this study was to assess the accuracy of energy expenditure (EE) estimation and step tracking abilities of six activity monitors (AMs) in relation to indirect calorimetry and hand counted steps and assess the accuracy of the AMs between high and low fit individuals in order to assess the impact of exercise intensity. Fifty participants wore the Basis watch, Fitbit Flex, Polar FT7, Jawbone, Omron pedometer, and Actigraph during a maximal graded treadmill test. Correlations, intra-class correla...

An Analysis of Foot and Ankle Device Recalls by the Food and Drug Administration.

Introduction Orthopaedic devices represent 12% of all medical device recalls. Products are approved through pre-market approval (PMA) or the 510(k) premarket notification process. No previous evaluation was found in the literature evaluating foot and ankle device recalls. The field of foot and ankle subspecialty has seen a rapid growth in innovation related to implants in recent years. Methods The Food and Drug Administration (FDA) Device Recall database was evaluated for all foot and ankle devices from 20...

Shadow study: randomized comparison of clinic with video follow-up in glioma undergoing adjuvant temozolomide therapy.

This study was designed with a primary objective to study the rate of agreement in treatment plan and decisions between video follow-up (VF) and conventional clinic follow-up (CF).

Achieving high value care for all and the perverse incentives of 340B price agreements.

Section 340B of the Public Health Service Act requires drug manufacturers to enter into price agreements with the Department of Health and Human Services. These agreements result in variation in the price paid to acquire a drug by sector, which complicates the price used in cost-effectiveness analyses. We describe the transactions and sectors in a 340B agreement using a multiple sclerosis drug. Cost-effectiveness estimates were calculated for the drug using drug prices from the manufacturer and payer perspe...

A Deprotonation Approach to the Unprecedented Amino-Trimethylenemethane Chemistry: Regio-, Diastereo-, and Enantioselective Synthesis of Complex Amino Cycles.

Here we report the first realization of the amino-trimethylenemethane chemistry. The approach employs a deprotonation strategy which simplified the synthesis of the amino- trimethylenemethane donor, requiring only two steps from commercial and inexpensive materials. A broad scope of cycloaddition acceptors (seven different classes) participated in the chemistry, chemo-, regio-, diastereo-, and enantioselectively, generating various types of highly valuable complex amino cycles. Multiple derivatization react...

Steps to Effective Problem-Solving in group homes.

Aggressive/challenging behaviors (A/CB) are a major public health problem for individuals with intellectual disabilities (ID). A leading reason for psychiatric hospitalizations and incarcerations, such behaviors are costly to the health care system, agencies, and families. Social problem-solving (SPS) training programs for individuals with ID have had positive behavioral results, but most were conducted in clinical or forensic settings. None was a community-based preventive intervention, none examined wheth...

A Chemical Time Machine for Mucosal Healing.

Mucosal healing regenerates the mucosal complex upon injury. Mucosal repair requires sequential biologic steps paradoxically enabled or blocked by prostaglandin E2. In this issue of Cell Host & Microbe, Jain et al. (2018) find that the microbial metabolite, deoxycholate, regulates prostaglandin E2 and thus coordinates the steps of mucosal healing.

Chemoenzymatic Synthesis of Galectin Binding Glycopolymers.

Chemoenzymatic synthesis is an important strategy for the formation of glycopolymers. The use of a smaller number of traditional chemical steps and enzyme catalyzed reactions increases the yield of glycopolymer that can be produced by reducing the overall number of synthetic steps. In addition, chemoenzymatic routes are likely to be more accessible to those without a background in carbohydrate synthesis, making glycopolymers more available for studies across a broader range of scientists. Here, the enzymati...

Post-production handling and administration of protein pharmaceuticals and potential instability issues.

The safety and efficacy of protein pharmaceuticals depend not only on biological activity, but also on purity levels. Impurities may be process related due to limitations in manufacturing, or product related caused by protein degradation occurring throughout the life history of a product. Although the pharmaceutical biotechnology industry has made great progress in improving bulk and drug product manufacturing as well as company-controlled storage and transportation conditions to minimize the level of degra...

Numerical analysis of surface and edge states in slabs, stripes, rods and surface steps of topological insulators.

By numerically solving the effective continuous model of a topological insulator with parameters corresponding to the band structure of the topological insulator BiSe, we analyze possible appearance of one-dimensional states in various geometries. Massless Dirac fermions are found at the edges of thin ribbons with surface oriented not only along the van der Waals gap but also in the perpendicular direction. Thick rods and slabs with surface steps host massive modes localized on surface faces. We argue that ...

First- and second-line bevacizumab in ovarian cancer: A Belgian cost-utility analysis.

Currently, in Belgium, bevacizumab is reimbursed for ovarian cancer patients, based on a contract between the Minister and the manufacturer including confidential agreements. This reimbursement will be re-evaluated in 2018.

Total Synthesis of (+)-Viridianol, a Marine-derived Sesquiterpene Embodying the Decahydrocyclobutadindene Framework.

A total synthesis of the title sesquiterpene 4 is described that starts with the chiral, non-racemic cis-1,2-dihydrocatechol 10 obtained through the whole-cell biotransformation of p-iodotoluene. Compound 10 is elaborated over seven steps, including Negishi cross-coupling and intramolecular Diels-Alder (IMDA) cycloaddition reactions, to ketone 7 that engages in a photochemically promoted 1,3-acyl migration and so affording cyclobutanone 6. Compound 6 was converted over further steps into the title compound ...

Total synthesis of cyrneines A-B and glaucopine C.

The cyrneine diterpenoids represent a structurally intriguing subfamily of cyathane diterpenoids and could significantly induce neurite outgrowth. Therefore, the efficient synthesis of these natural products is of great importance. Herein, we present a route for the collective synthesis of cyrneines A, B, and glaucopine C. As the key precursor, the 5-6-6-tricyclic scaffold is efficiently constructed by employing a mild Suzuki coupling of heavily substituted nonactivated cyclopentenyl triflate and a chelati...

Stray light in cone beam optical computed tomography: III. Evaluation of a redesigned large-volume commercial scanner based on a convergent light source.

Optical cone beam computed tomography (CT), using a digital camera to acquire 2D projection images, provides a fast, mechanically simple method for 3D radiation dosimetry. However, original cone beam designs had poor accuracy as a result of considerable scatter/stray light reaching the camera. Previously, our group presented a redesigned convergent light source for optical cone beam CT that considerably reduced stray light contribution and improved accuracy (Dekker et al 2016 Phys. Med. Biol. 61 2910). Here...

Going Forward Lightening the Shadow of Cancer: Experiences of Family Caregivers Toward Empowerment.

This qualitative study was conducted to explore the empowerment experiences of family caregivers of patients with cancer. Empowerment consisted of 3 main categories: (1) seeking tranquility with the help of religious beliefs, (2) developing a positive attitude, and (3) restoring control over the situation. Results may help nurses for planning spiritual and supportive care.

Defining the limits of detection for chromosome rearrangements in the preimplantation embryo using next generation sequencing.

Is next generation sequencing (NGS) capable of detecting smaller sub-chromosomal rearrangements in human embryos than the manufacturer's quoted resolution suggests?

Syntactic and semantic restrictions on morphological recomposition: MEG evidence from Greek.

Complex morphological processing has been extensively studied in the past decades. However, most of this work has either focused on only certain steps involved in this process, or it has been conducted on a few languages, like English. The purpose of the present study is to investigate the spatiotemporal cortical processing profile of the distinct steps previously reported in the literature, from decomposition to re-composition of morphologically complex items, in a relatively understudied language, Greek. ...

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