PubMed Journals Articles About "French Industry Welcomes Moves Speed Access Innovative Drugs" - Page: 2 RSS

18:34 EST 18th November 2018 | BioPortfolio

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Showing "French Industry Welcomes Moves Speed Access Innovative Drugs" PubMed Articles 26–50 of 12,000+

Childhood Trauma and the Inability to Access Hospital Care Among People who Inject Drugs.

Childhood traumatic experiences can disrupt attachment, influence personality development, and precipitate chronic disease. Although the repercussions of these experiences may also pose a barrier to healthcare, few studies have examined the association between childhood trauma and access to healthcare. Therefore, we sought to investigate whether a history of childhood trauma is associated with self-reported inability to access hospital care among persons who inject drugs (PWID). Data were derived from two p...

Identification of Factors Associated with First-Cycle Drug Approval Rates and Regulatory Outcomes for New Drug Applications.

The aims of this study were to identify types of deficiencies resulting in delay of approvals for drugs eventually approved by the US FDA and to search for factors associated with higher first-cycle approval rates. Review documents of New Drug Applications approved between 2008 and 2017 were retrieved from the Drugs@FDA database. Basic characteristics of the applications, regulatory actions, and reasons for non-approvals and/or major amendments after first review cycle were investigated. Of 825 applications...

Quantitative assessment of dietary supplement intake in 77,000 French adults: impact on nutritional intake inadequacy and excessive intake.

Dietary supplements (DS) are largely consumed in Western countries without demonstrating their nutritional benefits and safety in the general population. The aims, in a large population-based study of French adults, were: (1) to compare the prevalence of nutrient intake inadequacy and the proportion of individuals exceeding tolerable upper intake levels (UL) between DS users and non-users, and (2) to quantify the extent of potentially "at-risk" DS use practices (e.g., DS/drugs contraindicated association or...

The place of psychoanalysis in French psychiatry.

France is known as one of the countries where psychoanalysis still holds an important position in various fields, and specially in psychiatry. Is it a 'culture bound syndrome' of French society, or, more seriously, a particularity that could be useful in other contexts as well? Through consideration of the role psychoanalysis is playing in French psychiatry, this paper will try to review this particularity and its interactions with the organisation and values of psychiatry in France, both in the public serv...

A Global Public Health Perspective: Facilitating Access to Assistive Technology.

Clinicians should not overlook vulnerable populations with limited access to assistive technology (AT), the importance of collaboration in multidisciplinary teams, advocacy for enabling environments, and supportive health systems. Resources, a model of care, and recommendations can assist clinicians in contributing to changing attitudes, expanding knowledge, and improving the lives of many.The increasing availability of innovative advances in AT can immeasurably enhance the quality of life of people with di...

Challenges and Benefits of Repurposing Licensed/Approved/Cleared Products for a Radiation Indication.

Increasingly, the risk of a radiological or nuclear public health emergency is a major concern for the U.S. government. To address a potential incident and ensure that the U.S. Government is prepared to respond to any civilian or military casualties that could result, the U.S. Department of Health and Human Services (HHS), together with the Department of Defense, has been charged with the development of medical countermeasures (MCMs) to treat individuals experiencing acute and delayed injuries that can resu...

Perception of the speed of self-motion vs. object-motion: Another example of two modes of vision?

We investigated the effect of reduced contrast on speed perception for two types of tasks: (a) the speed of a rotating image, an example of "object-motion," and (b) speed of travel when viewing wide-screen videos recorded from inside a car, an example of "self-motion." Both types of stimuli were presented over a range of spatial contrasts. The results showed that reduced contrast caused significant decreases of perceived speed for the rotating disk, replicating the well known Thompson Effect. Reduced contra...

Applying Corporate Political Activity (CPA) analysis to Australian gambling industry submissions against regulation of television sports betting advertising.

This research aimed to assess the application to the gambling industry, of Corporate Political Activity (CPA) analysis previously developed from public health research on tobacco industry interactions with political institutions and previously applied to the alcohol industry, but not the gambling industry.

DairyWater: striving for sustainability within the dairy processing industry in the Republic of Ireland.

This Review describes the objectives and methodology of the DairyWater project as it aims to aid the Irish dairy processing industry in achieving sustainability as it expands. With the abolition of European milk quotas in March 2015, the Republic of Ireland saw a surge in milk production. The DairyWater project was established in anticipation of this expansion of the Irish dairy sector in order to develop innovative solutions for the efficient management of water consumption, wastewater treatment and the re...

Indication, access, and use of medicines for chronic respiratory diseases in Brazil: results from the National Survey on Access, Utilization, and Promotion of Rational Use of Medicines in Brazil (PNAUM), 2014.

The study aimed to estimate the prevalence of self-reported chronic respiratory diseases and the indication, access to, and use of medicines, as well as their sources, in the Brazilian adult population. Data were analyzed on adults 20 years and older from the National Survey on Access, Utilization, and Promotion of Rational Use of Medicines in Brazil (PNAUM), conducted from September 2013 to February 2014. Prevalence of chronic respiratory diseases was 3% (95%CI: 2.7-3.3). Of these individuals, 58.1% (95%CI...

Perceptions of French general practitioners and patients regarding dextropropoxyphene withdrawal: a qualitative study.

Dextropropoxyphene (DXP), a step 2 analgesic commonly prescribed in France, was withdrawn from the French market in 2011 following a European decision due to its poor risk-benefit ratio. The purpose of this study was to explore the perceptions of French general practitioners (GPs) and patients regarding DXP withdrawal.

State naloxone access laws are associated with an increase in the number of naloxone prescriptions dispensed in retail pharmacies.

In response to the ongoing opioid overdose epidemic, many states have enacted laws increasing naloxone access by lay people, such as friends and family members of people who use drugs (PWUD), as well as PWUD themselves.

An Innovative, Collaborative, and Strategic Approach to Proactively Evaluate and Update Drug Interactions Based on Prescribing Information of Newly Approved Medicinal Products.

Drug-drug interaction (DDIs) are evaluated using pharmacokinetic (PK) simulation models, clinical studies, and scientific publications throughout drug development. DDIs with Norvir (ritonavir) and combination products (eg, Kaletra [lopinavir/ritonavir]) containing ritonavir as a PK enhancer are relevant, because these drugs could affect exposures of CYP3A4 substrates. Application of algorithms proactively identified recently approved drugs, which potentially cause adverse outcomes when given with drugs cont...

Characterizing Speed Cells in the Rat Hippocampus.

Spatial navigation relies on visual landmarks as well as on self-motion information. In familiar environments, both place and grid cells maintain their firing fields in darkness, suggesting that they continuously receive information about locomotion speed required for path integration. Consistently, "speed cells" have been previously identified in the hippocampal formation and characterized in detail in the medial entorhinal cortex. Here we investigated speed-correlated firing in the hippocampus. We show ...

Innovative therapeutic approaches for hereditary neuromuscular diseases.

Advances in the understanding of the genetic mechanisms and pathophysiology of neuromuscular diseases have recently led to the development of new, innovative and often mutation-specific therapeutic approaches. Methods used include splicing modification by antisense oligonucleotides, read-through of premature stopcodons, use of viral vectors to introduce genetic information, or optimizing the effectiveness of enzyme replacement therapies. The first drugs have already been approved for the treatment of Duchen...

Industry Funding Is Correlated With Publication Productivity of US Academic Radiation Oncologists.

Industry payments to physicians are financial conflicts of interest and may influence research findings and medical decisions. We aim to (1) characterize industry payments within radiation oncology; and (2) explore the potential correlation between receiving disclosed industry payments and academic productivity.

Correction to: OnabotulinumtoxinA: A Review in the Prevention of Chronic Migraine.

The article OnabotulinumtoxinA: A Review in the Prevention of Chronic Migraine, written by James E. Frampton and Stephen Silberstein, was originally published Online First without open access. After publication in volume 78, issue 5, pages 589-600 [funder] requested that the article be Open Choice to make the article an open access publication. Post-publication open access was funded by [funder]. Further details may be found at [MedEngine webpage link].

Safety differentiation: emerging competitive edge in drug development.

With increasing expectations to provide evidence of drug efficacy, safety, and cost-effectiveness, best-in-class drugs are a major value driver for the pharmaceutical industry. Superior safety is a key differentiation criterion that could be achieved through better risk:benefit profiles, safety margins, fewer contraindications, and improved patient compliance. To accomplish this, comparative safety assessments using innovative and adaptive nonclinical and clinical outcome-based approaches should be undertak...

Bio-electrochemical system (BES) as an innovative approach for sustainable waste management in petroleum industry.

Petroleum industry is one of the largest and fast growing industries due to the ever increasing global energy demands. Petroleum refinery produces huge quantities of wastes like oily sludge, wastewater, volatile organic compounds, waste catalyst, heavy metals, etc., because of its high capacity and continuous operation of many units. Major challenge to this industry is to manage the huge quantities of waste generated from different processes due to the complexity of waste as well as changing stringent envir...

Non-contact identification and differentiation of illicit drugs using fluorescent films.

Sensitive and rapid identification of illicit drugs in a non-contact mode remains a challenge for years. Here we report three film-based fluorescent sensors showing unprecedented sensitivity, selectivity, and response speed to the existence of six widely abused illicit drugs, including methamphetamine (MAPA), ecstasy, magu, caffeine, phenobarbital (PB), and ketamine in vapor phase. Importantly, for these drugs, the sensing can be successfully performed after 5.0 × 10, 4.0 × 10, 2.0 × 10, 1.0...

Lost medicines: a longer view of the pharmaceutical industry with the potential to reinvigorate discovery.

It is widely understood that the 1962 Kefauver-Harris Amendment to the Food, Drug and Cosmetics Act ushered in the modern regulation of medicines requiring a combination of safety and efficacy. However, fewer appreciate the amendment was applied retroactively to virtually all medicines sold in the USA. For various reasons, many medicines faded into history. Here, we identify and analyze >1600 medicines (including over-the-counter drugs) and their innovators prior to the enactment of Kefauver-Harris. We repo...

Lexical borrowings from classical languages in the english and french medical terminologies: a comparative study.

Introduction: The present paper examines the types of terminological borrowings of classical origin in the modern English and French sublanguages of medicine. The aim: The authors aim to conduct the lexico-semantic analysis of borrowings from classical languages in the medical terminologies of English and French.

Impact of antiretroviral drugs on fracture risk in HIV-infected individuals: A case-control study nested within the French Hospital Database on HIV (FHDH-ANRS CO4).

HIV-infected patients have lower bone mineral density and a higher incidence of fractures than the general population of the same age and sex. To assess the impact of antiretroviral drugs (ARV) exposure on the risk of osteoporotic fractures, we conducted a nested case-control study.

Medication development: reducing casualties in the valley of death and providing support for survivors.

Ray et al (Ray et al., 2018) discuss several obstacles encountered in the transition from pre-clinical to human clinical testing in the development of novel medications for alcohol use disorders (AUD). A large number of promising drugs have perished in this transition phase, so large that the term "valley of death" has been proposed to characterize this perilous passage (Butler, 2008). Even when the valley of death has successfully been crossed the pathway to marketing remains highly problematic. In a pap...

Biosimilars: Expert consensus of the Latin American Society of Psoriasis (SOLAPSO) in Argentina.

With the appearance of biological treatments, therapeutics has changed in many rheumatological, dermatological and oncological diseases. Due to the high cost of these biological medicaments and the expiration of patents, the pharmacological industry develops biosimilars, drugs that are a version (copy) of the substance of the original biological medicine, with the aim of facilitating access to these treatments. These biosimilars are prepared according to the specific requirements of regulatory bodies in ter...

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