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Showing "Ganaxolone Phase Data Supports Progressing Phase Patients with" PubMed Articles 26–50 of 59,000+

Assessing the Correlation of Fecal Calprotectin and the Clinical Disease Activity Index in Patients With Ulcerative Colitis.

It has been shown that fecal calprotectin can be used to evaluate mucosal inflammation better than using clinical indices and serum markers. The aim of this study was to assess the use of fecal calprotectin for evaluating the disease activity in 2 groups of patients with ulcerative colitis and a control group. The study population consisted of 30 patients with active-phase ulcerative colitis, 30 remission-phase patients, and 30 healthy control patients. After obtaining informed consent, we took blood and fe...

Fast phase retrieval in off-axis digital holographic microscopy through deep learning.

Traditional digital holographic imaging algorithms need multiple iterations to obtain focused reconstructed image, which is time-consuming. In terms of phase retrieval, there is also the problem of phase compensation in addition to focusing task. Here, a new method is proposed for fast digital focus, where we use U-type convolutional neural network (U-net) to recover the original phase of microscopic samples. Generated data sets are used to simulate different degrees of defocused image, and verify that the ...

Chronotropic incompetence to exercise in anorexia nervosa patients during the body-weight recovery phase as an index of insufficient treatment.

Resting bradycardia is an important symptom for early diagnosis of anorexia nervosa (AN) during weight loss, and it improves with body-weight recovery. However, chronotropic incompetence (CI) in exercise is observed in some patients with AN despite amelioration of resting bradycardia in the recovery phase. We examined the relationship between CI in exercise and other parameters in patients with AN during the recovery phase. Ninety-two girls with AN (aged 13-20 years, median 15 years) performed cardiopulmo...

A phase 1/2 dose-finding, safety, and activity study of cabazitaxel in pediatric patients with refractory solid tumors including tumors of the central nervous system.

This phase 1/2 study (NCT01751308) evaluated cabazitaxel in pediatric patients. Phase 1 determined the maximum tolerated dose (MTD) in patients with recurrent/refractory solid tumors, including central nervous system (CNS) tumors. Phase 2 evaluated activity in pediatric recurrent high-grade glioma (HGG) or diffuse intrinsic pontine glioma (DIPG).

Aqueous-Phase Oxidation of Terpene-Derived Acids by Atmospherically Relevant Radicals.

Terpene-derived acids formed through the atmospheric gas-phase oxidation of terpenes are able to efficiently undergo a phase transfer into the aqueous phase. The subsequent aqueous-phase oxidation of such compounds has not been intensely studied. Accordingly, the aqueous-phase second order rate constants of the oxidation reactions of cis-pinonic acid (CPA) and (+)-camphoric acid (+CA) with hydroxyl radicals (OH), nitrate radicals (NO) and sulfate radicals (SO) were investigated as a function of temperature ...

Quantitative decision-making in randomized Phase II studies with a time-to-event endpoint.

One of the most critical decision points in clinical development is Go/No-Go decision-making after a proof-of-concept study. Traditional decision-making relies on a formal hypothesis testing with control of type I and type II error rates, which is limited by assessing the strength of efficacy evidence in a small isolated trial. In this article, we propose a quantitative Bayesian/frequentist decision framework for Go/No-Go criteria and sample size evaluation in Phase II randomized studies with a time-to-even...

An experimental investigation of n-hexane at high temperature and pressure.

At present, no high temperature experiments on phase change are reported. In this study, we have measured the Raman bands ν(CH), ν(CH), ν(CH), and ν(CH) of n-hexane in a hydrothermal diamond cell up to 588 K. We determined that the liquid-solid phase transition pressure of n-hexane is 1.17 GPa, and we also gave a number of high temperatures and pressures data on phase change which are not reported previously. In addition, we defined the solidus of n-hexane which can be represented by the equation P...

Survival outcome and prognostic model of patients with colorectal cancer on phase 1 trials.

Background Patients with metastatic colorectal cancer (mCRC) who progress on standard therapies may be eligible for phase I trials. To better delineate the risk-benefit ratio, we assessed toxicities, clinical outcomes and prognostic factors. Methods Records of mCRC patients on phase I trials at our institution over 18 years were reviewed. Univariable (UVA) and multivariable analyses (MVA) were undertaken and a prognostic model developed. Results There were 187 enrollments on 37 phase I trials. Median age w...

Laser-induced metastable phase in crystalline phase-change films by confocal Raman spectrometer.

Understanding crystallization process in phase-change materials is very important for data storage application. Especially, accurately controlling the metastable phase transition as well as characterizing its structure evolution is still under investigation. In this study, phase transformations have occurs from amorphous to crystalline phases when the phase-change films were irradiated continuously by the 785 nm laser irradiation. By adjusting the laser power, the different metastable phases in convention...

Outcomes of sequential treatment with sorafenib followed by regorafenib for HCC: additional analyses from the phase 3 RESORCE trial.

The RESORCE trial showed that regorafenib improves overall survival (OS) in patients with hepatocellular carcinoma progressing during sorafenib treatment (hazard ratio [HR] 0.62, 95% confidence interval [CI] 0.50, 0.78; P

Modulating complex beams in amplitude and phase using fast tilt-micromirror arrays and phase masks.

The Letter proposes a system for the spatial modulation of light in amplitude and phase at kilohertz frame rates and high spatial resolution. The focus is fast spatial light modulators (SLMs) consisting of continuously tiltable micromirrors. We investigate the utilization of such SLMs in combination with a static phase mask in a 4f setup. The phase mask enables the complex beam modulation in a linear optical arrangement. Furthermore, adding so-called phase steps to the phase mask increases both the number o...

Luteal phase stimulation, the future of fertility preservation? Retrospective cohort study of luteal phase versus follicular phase stimulation.

The pre-stimulus oscillatory alpha phase affects neural correlates of early visual perception.

A growing number of studies suggest the phase of ongoing alpha oscillations in the brain influences visual perception. However, it remained largely unconsidered if this is associated with a phase dependence of neurophysiological processes especially in the visual cortex. Therefore, this study investigated the link between the pre-stimulus oscillatory alpha phase and neural correlates of early visual perception. In 64 subjects a 64-channel EEG system was used to examine the phase dependence of pattern-revers...

Identification of differentially expressed proteins in rats with spinal cord injury during the transitional phase using an iTRAQ-based quantitative analysis.

Spinal cord injury (SCI) is a disease associated with high disability and mortality rates. The transitional phase from subacute phase to intermediate phase may play a major role in the process of secondary injury. Changes in protein expression levels have been shown to play key roles in many central nervous system (CNS) diseases. Nevertheless, the roles of proteins in the transitional phase of SCI are not clear.

Direct information retrieval after 3D reconstruction in grating-based X-ray phase-contrast computed tomography.

Grating-based X-ray differential phase-contrast imaging has attracted a great amount of attention and has been considered as a potential imaging method in clinical medicine because of its compatibility with the traditional X-ray tube source and the possibility of a large field of view. Moreover, phase-contrast computed tomography provides three-dimensional phase-contrast visualization. Generally, two-dimensional information retrieval performed on every projection is required prior to three-dimensional recon...

Optimized random phase encryption.

We propose for the first time, to the best of our knowledge, the use of optimized random phases (ORAPs) in a double random phase encryption scheme (DRPE). In DRPE schemes the convolution between two random phase functions encrypts the information to be secured. However, in actual encryption applications, this convolution of random phases also results in unwanted effects like speckle noise. In this Letter we show that under certain conditions this noise can be drastically reduced. These conditions can be eas...

Predictors of hypomanic and/or manic switch among patients who initially diagnosed unipolar major depression during acute phase antidepressants treatment.

Most patients with bipolar disorder have depressive onset polarity. There is, however, very few studies investigating predictors of hypomanic and/or manic change for patients with major depression in Japan. We preliminary explored predictors of hypomanic and/or manic switch during acute phase antidepressants treatment by using the data of the SUND trial that is a multi-center randomized controlled clinical trial. Total of 2011 patients participated and the main findings are published elsewhere. This article...

Increased sensitivity of the circadian system to light in delayed sleep-wake phase disorder.

This is the first study to demonstrate an altered circadian phase shifting response in a circadian rhythm sleep disorder. Patients with Delayed Sleep-Wake Phase Disorder (DSWPD) demonstrate greater sensitivity of the circadian system to the phase delaying effects of light. Increased circadian sensitivity to light is associated with later circadian timing within both control and DSWPD groups. DSWPD patients had a greater sustained pupil response after light exposure. Treatments for DSWPD should consider sens...

Adsorption of molecular oxygen on the Ag(111) surface: A combined temperature-programmed desorption and scanning tunneling microscopy study.

The adsorption of O on Ag(111) between 300 and 500 K has been studied with temperature-programmed desorption (TPD) and scanning tunneling microscopy (STM). At the first stage of adsorption, the disordered local oxide phase (commonly looking in STM as an array of black spots) is formed on the surface irrespective of the substrate temperature. The maximum concentration of black spots was found to be ≈0.11 ML, which corresponds to an oxygen coverage of ≈0.66 ML. Taking into account that the nucleation of t...

The Impact of Heart Rate Response During 48-Hour Rewarming Phase of Therapeutic Hypothermia on Neurologic Outcomes in Out-of-Hospital Cardiac Arrest Patients.

Bradycardia during therapeutic hypothermia has been reported to be a predictor of favorable neurologic outcomes in out-of-hospital cardiac arrests. However, bradycardia occurrence rate may be influenced by the target body temperature. During therapeutic hypothermia, as part of the normal physiologic response, heart rate decreases in the cooling phase and increases during the rewarming phase. We hypothesized that increased heart rate during the rewarming phase is another predictor of favorable neurologic out...

Concizumab restores thrombin generation potential in patients with haemophilia: Pharmacokinetic/pharmacodynamic modelling results of concizumab phase 1/1b data.

Concizumab enhances thrombin generation (TG) potential in haemophilia patients by inhibiting tissue factor pathway inhibitor (TFPI). In EXPLORER3 (phase 1b), a dose-dependent pharmacokinetic/pharmacodynamic (PK/PD) relationship was confirmed between concizumab dose, free TFPI and TG potential.

The Role of RNA in Biological Phase Separations.

Phase transitions that alter the physical state of ribonucleoprotein particles contribute to the spacial and temporal organization of the densely packed intracellular environment. This allows cells to organize biologically coupled processes as well as respond to environmental stimuli. RNA plays a key role in phase separation events that modulate various aspects of RNA metabolism. Here, we review the role that RNA plays in ribonucleoprotein phase separations.

Characterization of Comorbidities Limiting the Recruitment of Patients in Early Phase Clinical Trials.

Early phase clinical trials evaluate the safety and efficacy of new treatments. The exclusion/inclusion criteria in these trials are usually rigorous and may exclude many patients seen in clinical practice. Our objective was to study the comorbidities limiting the participation of patients with breast, colorectal, or lung cancer in clinical trials.

Intriguing Structural Transition Inducing Variable Birefringences in ABaMSCl (A = Rb, Cs; M = Ge, Sn).

A suite of quinary thiohalides, ABaMSCl (A = Rb, Cs; M = Ge, Sn), have been successfully synthesized. ABaMSCl (A = Rb, Cs; M = Ge, Sn) undergoes an interesting structural transition from P2/ c (α phase) to I4/ mcm (β phase), which also leads to obvious disparities on the birefringence from 0.041 (α phase) to 0.094 (β phase). Moreover, the result of deploying a real-space atom-cutting method on ABaMSCl reveals that their (MS) groups may take the major effect in terms of the anisotropy by a structural tra...

Phase transition and hardness evolution of a Ti-5Al-5Mo-1Fe-1Cr alloy subjected to isothermal aging.

In this paper, a Ti-5Al-5Mo-1Fe-1Cr alloy was isothermally aged at 500 °C for different periods. Phase transformation took place during the aging treatment. The phase transformation was studied by X-ray diffraction spectroscopy and transmission electron microscopy. The as-quenched sample was composed of matrix β (body-centered cubic structure) phase, ω (hexagonal structure) phase and minor α (hexagonal close-packed structure) phase. The results showed that aging treatment promoted the β → ω → α...

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