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PubMed Journals Articles About "Ganaxolone Phase Data Supports Progressing Phase Patients With" - Page: 2 RSS

23:22 EDT 22nd September 2018 | BioPortfolio

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Showing "Ganaxolone Phase Data Supports Progressing Phase Patients with" PubMed Articles 26–50 of 59,000+

Fast phase retrieval in off-axis digital holographic microscopy through deep learning.

Traditional digital holographic imaging algorithms need multiple iterations to obtain focused reconstructed image, which is time-consuming. In terms of phase retrieval, there is also the problem of phase compensation in addition to focusing task. Here, a new method is proposed for fast digital focus, where we use U-type convolutional neural network (U-net) to recover the original phase of microscopic samples. Generated data sets are used to simulate different degrees of defocused image, and verify that the ...


A phase 1/2 dose-finding, safety, and activity study of cabazitaxel in pediatric patients with refractory solid tumors including tumors of the central nervous system.

This phase 1/2 study (NCT01751308) evaluated cabazitaxel in pediatric patients. Phase 1 determined the maximum tolerated dose (MTD) in patients with recurrent/refractory solid tumors, including central nervous system (CNS) tumors. Phase 2 evaluated activity in pediatric recurrent high-grade glioma (HGG) or diffuse intrinsic pontine glioma (DIPG).

Quantitative decision-making in randomized Phase II studies with a time-to-event endpoint.

One of the most critical decision points in clinical development is Go/No-Go decision-making after a proof-of-concept study. Traditional decision-making relies on a formal hypothesis testing with control of type I and type II error rates, which is limited by assessing the strength of efficacy evidence in a small isolated trial. In this article, we propose a quantitative Bayesian/frequentist decision framework for Go/No-Go criteria and sample size evaluation in Phase II randomized studies with a time-to-even...


An experimental investigation of n-hexane at high temperature and pressure.

At present, no high temperature experiments on phase change are reported. In this study, we have measured the Raman bands ν(CH), ν(CH), ν(CH), and ν(CH) of n-hexane in a hydrothermal diamond cell up to 588 K. We determined that the liquid-solid phase transition pressure of n-hexane is 1.17 GPa, and we also gave a number of high temperatures and pressures data on phase change which are not reported previously. In addition, we defined the solidus of n-hexane which can be represented by the equation P...

Optimized random phase only holograms.

We propose a simple and efficient technique capable of generating Fourier phase only holograms with a reconstruction quality similar to the results obtained with the Gerchberg-Saxton (G-S) algorithm. Our proposal is to use the traditional G-S algorithm to optimize a random phase pattern for the resolution, pixel size, and target size of the general optical system without any specific amplitude data. This produces an optimized random phase (ORAP), which is used for fast generation of phase only holograms of ...

Outcomes of sequential treatment with sorafenib followed by regorafenib for HCC: additional analyses from the phase 3 RESORCE trial.

The RESORCE trial showed that regorafenib improves overall survival (OS) in patients with hepatocellular carcinoma progressing during sorafenib treatment (hazard ratio [HR] 0.62, 95% confidence interval [CI] 0.50, 0.78; P

Bayesian sample size determination for a Phase III clinical trial with diluted treatment effect.

When Phase III treatment effect is diluted from what was observed from Phase II results, we propose to determine the Bayesian sample size for a Phase III clinical trial based on the normal, uniform, and truncated normal prior distributions of the treatment effects on an interval, which starts from an acceptable treatment effect to the observed treatment effect from Phase II. After incorporating the prior information of the treatment effects, the Bayesian sample size is the number of patients of the Phase II...

Laser-induced metastable phase in crystalline phase-change films by confocal Raman spectrometer.

Understanding crystallization process in phase-change materials is very important for data storage application. Especially, accurately controlling the metastable phase transition as well as characterizing its structure evolution is still under investigation. In this study, phase transformations have occurs from amorphous to crystalline phases when the phase-change films were irradiated continuously by the 785 nm laser irradiation. By adjusting the laser power, the different metastable phases in convention...

Modulating complex beams in amplitude and phase using fast tilt-micromirror arrays and phase masks.

The Letter proposes a system for the spatial modulation of light in amplitude and phase at kilohertz frame rates and high spatial resolution. The focus is fast spatial light modulators (SLMs) consisting of continuously tiltable micromirrors. We investigate the utilization of such SLMs in combination with a static phase mask in a 4f setup. The phase mask enables the complex beam modulation in a linear optical arrangement. Furthermore, adding so-called phase steps to the phase mask increases both the number o...

The pre-stimulus oscillatory alpha phase affects neural correlates of early visual perception.

A growing number of studies suggest the phase of ongoing alpha oscillations in the brain influences visual perception. However, it remained largely unconsidered if this is associated with a phase dependence of neurophysiological processes especially in the visual cortex. Therefore, this study investigated the link between the pre-stimulus oscillatory alpha phase and neural correlates of early visual perception. In 64 subjects a 64-channel EEG system was used to examine the phase dependence of pattern-revers...

Identification of differentially expressed proteins in rats with spinal cord injury during the transitional phase using an iTRAQ-based quantitative analysis.

Spinal cord injury (SCI) is a disease associated with high disability and mortality rates. The transitional phase from subacute phase to intermediate phase may play a major role in the process of secondary injury. Changes in protein expression levels have been shown to play key roles in many central nervous system (CNS) diseases. Nevertheless, the roles of proteins in the transitional phase of SCI are not clear.

Direct information retrieval after 3D reconstruction in grating-based X-ray phase-contrast computed tomography.

Grating-based X-ray differential phase-contrast imaging has attracted a great amount of attention and has been considered as a potential imaging method in clinical medicine because of its compatibility with the traditional X-ray tube source and the possibility of a large field of view. Moreover, phase-contrast computed tomography provides three-dimensional phase-contrast visualization. Generally, two-dimensional information retrieval performed on every projection is required prior to three-dimensional recon...

Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation.

Cytoplasmic FUS aggregates are a pathological hallmark in a subset of patients with frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS). A key step that is disrupted in these patients is nuclear import of FUS mediated by the import receptor Transportin/Karyopherin-β2. In ALS-FUS patients, this is caused by mutations in the nuclear localization signal (NLS) of FUS that weaken Transportin binding. In FTD-FUS patients, Transportin is aggregated, and post-translational arginine methylation, w...

Optimized random phase encryption.

We propose for the first time, to the best of our knowledge, the use of optimized random phases (ORAPs) in a double random phase encryption scheme (DRPE). In DRPE schemes the convolution between two random phase functions encrypts the information to be secured. However, in actual encryption applications, this convolution of random phases also results in unwanted effects like speckle noise. In this Letter we show that under certain conditions this noise can be drastically reduced. These conditions can be eas...

Description of adsorption in liquid chromatography under non-ideal conditions.

A thermodynamically consistent description of binary adsorption in reversed phase chromatography is presented, accounting for thermodynamic nonidealities in the liquid and the adsorbed phase. The investigated system involves the adsorbent Zorbax 300SB-C18, as well as phenetole (PNT) and 4-tert-butylphenol (TBP) as solutes and methanol and water as inert components forming the eluent. The description is based on adsorption isotherms which are a function of the liquid phase activities, in order to account for...

Phase conjugate digital inline holography (PCDIH).

Digital inline holography (DIH) provides instantaneous three-dimensional (3D) measurements of diffracting objects; however, phase disturbances in the beam path can distort the imaging. In this Letter, a phase conjugate digital inline holography (PCDIH) configuration is proposed for removal of phase disturbances. Brillouin-enhanced four-wave mixing produces a phase conjugate signal that back propagates along the DIH beam path. The results demonstrate the removal of distortions caused by gas-phase shocks to r...

Adsorption of molecular oxygen on the Ag(111) surface: A combined temperature-programmed desorption and scanning tunneling microscopy study.

The adsorption of O on Ag(111) between 300 and 500 K has been studied with temperature-programmed desorption (TPD) and scanning tunneling microscopy (STM). At the first stage of adsorption, the disordered local oxide phase (commonly looking in STM as an array of black spots) is formed on the surface irrespective of the substrate temperature. The maximum concentration of black spots was found to be ≈0.11 ML, which corresponds to an oxygen coverage of ≈0.66 ML. Taking into account that the nucleation of t...

The Impact of Heart Rate Response During 48-Hour Rewarming Phase of Therapeutic Hypothermia on Neurologic Outcomes in Out-of-Hospital Cardiac Arrest Patients.

Bradycardia during therapeutic hypothermia has been reported to be a predictor of favorable neurologic outcomes in out-of-hospital cardiac arrests. However, bradycardia occurrence rate may be influenced by the target body temperature. During therapeutic hypothermia, as part of the normal physiologic response, heart rate decreases in the cooling phase and increases during the rewarming phase. We hypothesized that increased heart rate during the rewarming phase is another predictor of favorable neurologic out...

The Role of RNA in Biological Phase Separations.

Phase transitions that alter the physical state of ribonucleoprotein particles contribute to the spacial and temporal organization of the densely packed intracellular environment. This allows cells to organize biologically coupled processes as well as respond to environmental stimuli. RNA plays a key role in phase separation events that modulate various aspects of RNA metabolism. Here, we review the role that RNA plays in ribonucleoprotein phase separations.

Intriguing Structural Transition Inducing Variable Birefringences in ABaMSCl (A = Rb, Cs; M = Ge, Sn).

A suite of quinary thiohalides, ABaMSCl (A = Rb, Cs; M = Ge, Sn), have been successfully synthesized. ABaMSCl (A = Rb, Cs; M = Ge, Sn) undergoes an interesting structural transition from P2/ c (α phase) to I4/ mcm (β phase), which also leads to obvious disparities on the birefringence from 0.041 (α phase) to 0.094 (β phase). Moreover, the result of deploying a real-space atom-cutting method on ABaMSCl reveals that their (MS) groups may take the major effect in terms of the anisotropy by a structural tra...

MRI gradient-echo phase contrast of the brain at ultra-short TE with off-resonance saturation.

Larmor-frequency shift or image phase measured by gradient-echo sequences has provided a new source of MRI contrast. This contrast is being used to study both the structure and function of the brain. So far, phase images of the brain have been largely obtained at long echo times as maximum phase signal-to-noise ratio (SNR) is achieved at TE = T2* (∼40 ms at 3T). The structures of the brain, however, are compartmentalized and complex with a wide range of signal relaxation times. At such long TE, the sho...

First Six Dimensional Phase Space Measurement of an Accelerator Beam.

This Letter presents the first complete six dimensional phase space measurement of a beam in an accelerator. The measurement was made on the Spallation Neutron Source Beam Test Facility. The data reveal previously unknown correlations in the six dimensional phase space distribution that are not visible in lower dimensionality measurements. The correlations are shown to be intensity dependent.

Phase transition and hardness evolution of a Ti-5Al-5Mo-1Fe-1Cr alloy subjected to isothermal aging.

In this paper, a Ti-5Al-5Mo-1Fe-1Cr alloy was isothermally aged at 500 °C for different periods. Phase transformation took place during the aging treatment. The phase transformation was studied by X-ray diffraction spectroscopy and transmission electron microscopy. The as-quenched sample was composed of matrix β (body-centered cubic structure) phase, ω (hexagonal structure) phase and minor α (hexagonal close-packed structure) phase. The results showed that aging treatment promoted the β → ω → α...

Ultrafast Control of Phase and Polarization of Light Expedited by Hot-Electron Transfer.

All-optical modulation is an entangled part of ultrafast nonlinear optics with promising impacts on tunable optical devices in the future. Current advancements in all-optical control predominantly offer modulation by means of altering light intensity, while the ultrafast manipulation of other attributes of light have yet to be further explored. Here, we demonstrate the active modulation of the phase, polarization, and amplitude of light through the nonlinear modification of the optical response of a plasmon...

Intramuscular allopregnanolone and ganaxolone in a mouse model of treatment-resistant status epilepticus.

Allopregnanolone (5α-pregnan-3α-ol-20-one) and its synthetic 3β-methyl analog, ganaxolone, are positive allosteric modulators of synaptic and extrasynaptic γ-aminobutyric acid (GABA)receptors that exhibit antiseizure activity in diverse animal seizure models, including models of status epilepticus (SE). The 2 neuroactive steroids are being investigated as treatments for SE, including as a treatment for SE induced by chemical threat agents. Intramuscular injection is the preferred route of administration...


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