PubMed Journals Articles About "Indivior Warns Potential Loss This Year Star Drug" - Page: 2 RSS

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Showing "Indivior warns potential loss this year star drug" PubMed Articles 26–50 of 42,000+

Drug-Coated balloon angioplasty in clinical practice for below the knee, popliteal and crural artery lesions causing critical limb ischaemia: One-year results from the Spanish Luminor Registry.

Luminor is a new drug-coated angioplasty balloon, European Conformity (EC)-market approved. The aim of the present study is to analyse the one-year results, in terms of effectiveness and safety, of the Luminor 14/14M and 35 Drug-Coated Balloons (DCBs) in a special cohort of critical limb ischaemia (CLI) of the Luminor Registry.

Influence of Energy Balance on the Rate of Weight Loss Throughout One Year of Roux-en-Y Gastric Bypass: a Doubly Labeled Water Study.

To investigate the influence of changes in energy balance and body composition on the rate of weight loss throughout 1 year of Roux-en-Y gastric bypass.

Antimicrobial Resistance Profiles and Molecular Characteristics of Coagulase-Negative Staphylococci Isolated from Two Tertiary Hospitals Before and 15 Years After Implementation of the Separation of Drug Prescribing and Dispensing Policy of Korea.

This study compared changes in antimicrobial susceptibilities and molecular characteristics of coagulase-negative staphylococci (CNS) between the year 2000 and the year 2014-2015 to evaluate the policy of separating drug prescribing and dispensing in Korea. We obtained 68 CNS clinical isolates from two tertiary general hospitals before (the year 2000;  = 25) and after (the year 2014 - 2015;  = 43) implementation of the separation. Isolates were identified as , , , , , and When minimal inhibitor...

Therapeutic Drug Monitoring in Pregnant Patients.

During pregnancy, there are several physiological changes during each trimester that can affect the absorption, distribution, metabolism, and elimination of drugs. Although, there is a potential need to understand the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs in pregnant patients, therapeutic drug monitoring (TDM) is not well established for various drug classes due to ethical and safety concerns regarding the neonate. Potential risks from in utero drug exposure to the fetus may impact growth...

Prevalence of drugs of abuse found in testing of illicit drug seizures and urinalysis of selected population in Hong Kong.

The study investigates the prevalence of drugs of abuse detected from 2011 to 2015 through (i) forensic drug testing of illicit drug seizures from law enforcement agencies; and (ii) analysis of common drugs of abuse in urine samples obtained from offenders/probationers under mandatory drug-use surveillance programmes. Under the selected drug testing groups, there were an average of 5334 cases/year of illicit drug seizures examined and 28,438 samples/year requiring drugs of abuse analysis in urine, from 2011...

Potential drug-drug interactions between antiretroviral therapy and treatment regimens for multi-drug resistant tuberculosis: implications for HIV care of MDR-TB co-infected individuals.

HIV-positive TB co-infected patients are at increased risk of multidrug-resistant (MDR)-TB compared to HIV-negative patients. Co-treatment of MDR-TB and HIV is common particularly in Sub-Saharan Africa where the co-morbidity is endemic. We discuss potential cellular metabolic pathway-mediated drug-drug interactions and the possible effect on HIV treatment outcomes of commonly prescribed antiretroviral therapy.

Therapeutic implications of nanomedicine for ocular drug delivery.

Ocular nanomedicine poses a promising therapeutic potential and offers many advantages over conventional ophthalmic medications for effective ocular drug delivery; because nanomedicine can overcome ocular barriers, improve drug-release profiles and reduce potential drug toxicity. Delivering therapeutics to the eye is challenging on multiple levels: rapid clearance of eyedrops from the ocular surface requires frequent instillation, which is difficult for patients; transport of drugs across the blood-retinal ...

Therapeutic Drug Monitoring to Guide Clinical Decision Making in Inflammatory Bowel Disease Patients with Loss of Response to Anti-TNF: A Delphi Technique-Based Consensus.

Loss of response is frequently encountered in patients with inflammatory bowel disease (IBD) treated with antitumor necrosis factor (TNF) agents. Therapeutic drug monitoring (TDM) and antidrug antibody measurement are increasingly used in this setting.

Tuberculosis drug discovery in the CRISPR era.

Stewart Cole and colleagues determined the complete genome sequence of Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), in 1998 [1]. This was a landmark achievement that heralded a new age in TB drug discovery. With the genome sequence in hand, drug discoverers suddenly had thousands of new potential targets to explore. But the excitement has since faded [2]. It is unquestioned that genomics has transformed our understanding of the biology of this pathogen. However, the expectat...

Aneuploidy enables cross-adaptation to unrelated drugs.

Aneuploidy is common both in tumor cells responding to chemotherapeutic agents and in fungal cells adapting to antifungal drugs. Because aneuploidy simultaneously affects many genes, it has the potential to confer multiple phenotypes to the same cells. Here, we analyzed the mechanisms by which Candida albicans, the most prevalent human fungal pathogen, acquires the ability to survive both chemotherapeutic agents and antifungal drugs. Strikingly, adaptation to both types of drugs was accompanied by the acqui...

Potential drug-drug interactions and risk of unplanned hospitalization in older patients with cancer: A survey of the prospective ELCAPA (ELderly CAncer PAtients) cohort.

Because of comorbidities and polypharmacy, older patients with cancer have a greater risk of iatrogenic events. We aimed to characterize potential drug-drug interactions (PDIs) and the risk of unplanned hospitalization in older patients with cancer treated with antineoplastic agents (ANAs).

Complete Recovery following Electroacupuncture Therapy in Refractory Unilateral Sensorineural Hearing Loss.

Role of electroacupucture (EA) in refractory unilateral sensorineural hearing loss (SNHL) remains unclear but might be promising for the Meniere's disease (MD). Two cases of unilateral SNHL who were unresponsive to conventional treatment of sudden SNHL showed complete recovery after receiving EA therapy. The first case was a 46-year-old female who received EA in the seventh month after the acute onset of sudden right hearing loss and tinnitus. She had mild-to-moderate degree of sensorineural hearing loss at...

Generation, Characterization, and Quantitative Bioanalysis of Drug/Anti-drug Antibody Immune Complexes to Facilitate Dedicated In Vivo Studies.

Immunogenicity against biotherapeutics can lead to the formation of drug/anti-drug-antibody (ADA) immune complexes (ICs) with potential impact on safety and drug pharmacokinetics (PK). This work aimed to generate defined drug/ADA ICs, characterized by quantitative (bio) analytical methods for dedicated determination of IC sizes and IC profile changes in serum to facilitate future in vivo studies.

The clinical performance of narrow diameter implants versus regular diameter implants: A systematic review and meta-analysis.

The purpose of the study is to analyze the 1-year and 3-year clinical performance of NDIs compared with RDIs.An electronic search from electronic databases and a hand search was performed from inception to April 2018. A meta-regression was used to evaluate the effects of the "fixed effects" model on the implant survival, prosthesis success rates and marginal bone loss with follow-up time of 1 year and 3 years. Of the 11 studies included, The overall pooled 1-year implant survival rates were 98.14% for NDIs ...

Prescription drug suicide in non-abusers: A 6-year forensic survey.

Prescription drug suicide merits study to guide the development of strategies to reduce suicide risk. We examined prescription drug suicide specifically in non-abusers of prescription drugs; this is a relatively unexplored subject.

Discovery of potential Toxoplasma gondii CDPK1 inhibitors with new scaffolds based on the combination of QSAR and scaffold-hopping method with in-vitro validation.

To discover drugs for toxoplasmosis with less side effects and less probability to get drug resistance is eagerly appealed for pregnant women, infant or immunocompromised patients. In this work, using TgCDPK1 as drug target, we design a method to discover new inhibitors for CDPK1 as potential drug lead for toxoplasmosis with novel scaffolds based on the combination of 2D/3D-QSAR and scaffold-hopping methods. All the binding sites of the potential inhibitors were checked by docking method and only the ones t...

Transfection of autologous host cells in vivo using gene activated scaffolds incorporating star-polypeptides.

It is increasingly being recognised within the field of tissue engineering that the regenerative capacity of biomaterial scaffolds can be augmented via the incorporation of gene therapeutics. However, the field still lacks a biocompatible gene delivery vector which is capable of functionalizing scaffolds for tailored nucleic acid delivery. Herein, we describe a versatile, collagen based, gene-activated scaffold platform which can transfect autologous host cells in vivo via incorporation of star-shaped poly(...

Advances in differentiation therapy for osteosarcoma.

Differentiation therapy involves the use of agents that can induce differentiation in cancer cells, with the irreversible loss of tumour phenotype. The application of differentiation therapy in osteosarcoma has made progress because of a better understanding of the potential links between differentiation defects and tumorigenesis. Here, we review recent studies on differentiation therapy for osteosarcoma, describing a variety of differentiation inducers. By highlighting these examples of drug-induced osteos...

Aripiprazole causing false positive urine amphetamine drug screen in an adult patient with bipolar disorder.

There has been only a few reports regarding aripiprazole causing false positive urine amphetamine drug screens, exclusively on children accidently ingesting aripiprazole. Herein, we present the first reported case of a 40 year old woman affected by Bipolar I Disorder, treated with aripirazole at therapeutic oral dose ranging from 15 mg/day to 30 mg/day, in the context of a depressive episode with mixed and psychotic features, showing a false positive urine amphetamine drug screen. We document the rela...

Oral antibiotics in acne: a retrospective single centre analysis of current prescribing in primary care and it's alignment with the national antibiotic quality premium.

Oral antibiotics are widely prescribed for acne due to anti-inflammatory and antimicrobial action against Propionibacterium acnes. Potential for antibiotic resistance is a global concern. Public Health England (PHE) estimates 10 million deaths/year by 2050 and £66 trillion in loss of productivity globally, due to drug-resistant microbial infections. NHS England recently developed a Quality Premium for antibiotic use, incentivising Clinical Commissioning Groups (CCGs) to reduce antibiotic prescribing in pri...

Discovery of Noncancer Drug Effects on Survival in Electronic Health Records of Patients With Cancer: A New Paradigm for Drug Repurposing.

Drug development is becoming increasingly expensive and time consuming. Drug repurposing is one potential solution to accelerate drug discovery. However, limited research exists on the use of electronic health record (EHR) data for drug repurposing, and most published studies have been conducted in a hypothesis-driven manner that requires a predefined hypothesis about drugs and new indications. Whether EHRs can be used to detect drug repurposing signals is not clear. We want to demonstrate the feasibility o...

How, When, and For Whom Should We Perform Therapeutic Drug Monitoring?

The implementation of therapeutic drug monitoring (TDM) in the inflammatory bowel disease (IBD) practice has evolved during the years. In the early days, the focus was merely on the measuring and reporting of drug concentrations. Later, these concentrations were considered in light of target concentrations that are related to clinical response. This did not only allow passively predicting a patient's future response, but it also triggered physicians and pharmacists to actively use the information to optimiz...

A real-world experience of drug eluting and non-drug eluting stents in lower extremity peripheral arterial disease.

Drug-eluting stents (DES) have been promoted as an alternative to the traditional non-drug eluting stents (nDES), and offer the potential for improved patency rates. However, DES are more expensive than nDES, and results comparing these stents outside of clinical trials have been limited.

Synthesis and evaluation of injectable thermosensitive penta-block copolymer hydrogel (PNIPAAm-PCL-PEG-PCL-PNIPAAm) and star-shaped poly(CL─CO─LA)-b-PEG for wound healing applications.

Loss of skin integrity due to injury, burning, or illness makes the development of new treatment options necessary. Skin tissue engineering provides some solutions for these problems.

What Is New in Recurrent Pregnancy Loss?: Best Articles From the Past Year.

This month we focus on current research in recurrent pregnancy loss. Dr. Ros discusses four recent publications, which are concluded with a "bottom-line" that is the take-home message. A complete reference for each can be found on Box 1 on this page along with direct links to abstracts.

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