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Constipation is commonly diagnosed in our pediatric ED. Care has varied significantly, with a heavy reliance on abdominal radiography (AR) for diagnosis and inpatient management for bowel cleanout. We implemented a standardized approach to caring for patients presenting to a pediatric ED with symptoms consistent with constipation, emphasizing clinical history, physical exam, less reliance on AR, and standardized home management.
Adaptive management addresses uncertainty about the processes influencing resource dynamics, as well as the elements of decision making itself. The use of management to reduce both kinds of uncertainty is known as double-loop learning. Though much work has been done on the theory and procedures to address structural uncertainty, there has been less progress in developing an explicit approach for institutional learning about decision elements. Our objective is to describe evidence-based learning about the de...
The rising demand for feed and food has put an increasing pressure on agriculture, with agricultural intensification as a direct response. Notwithstanding the higher crop productivity, intensive agriculture management entails many adverse environmental impacts. Worldwide, soil organic carbon (SOC) decline is hereby considered as a main danger which affects soil fertility and productivity. The life cycle perspective helps to get a holistic overview when evaluating the environmental sustainability of agricult...
Chronic hepatitis B infection affects 240 million people, with the highest prevalence in Africa and Asia, and results in 700 000 deaths annually. Access to diagnostics, particularly for hepatitis B virus viral load quantification (HBV DNA), is a major barrier to treatment. We aimed to test World Health Organization guidelines for hepatitis B management in resource-limited settings.
The mechanical properties of human facial skin are of considerable importance for clinical research and cosmetic industry. As a result of their susceptibility to the individual difference and complex surroundings of human beings, the in vivo mechanical characterization by objective and quantitative devices is challenging.
Duchenne muscular dystrophy (DMD) is a devastating, progressive neuromuscular disorder for which there is no cure. As the dystrophin gene is located on the X chromosome, DMD occurs predominately in males. DMD is caused by a lack of functional dystrophin protein resulting from mutations in the 2.2-Mb DMD gene, whichdisrupts the reading frame. Care considerations for DMD advocate a coordinated, multidisciplinary approach to the management of DMD in order to optimize management of the primary manifestations of...
Two major concerns over the chemical industrial park (CIP) operations are high consumption of water resources and large amount of pollutant emissions. This study develops an interval chance-constrained programming model for industrial water resources management (ICCP-IWM) with consideration of multi-uncertainty and multi-environmental constraints. Uncertainties expressed as intervals and probability distributions are merged in the ICCP-IWM framework. The developed model is used to solve a real-world water r...
Respiratory viruses cause significant morbidity and death in infants; 99% of such deaths occur in resource-limited settings. Risk factors for initial and repeated respiratory viral infections in young infants in resource-limited settings have not been well described.
Emotional intelligence (EI) training is popular among human resource practitioners, but there is limited evidence of the impact of such training on health care workers.
Nonoperative management of blunt solid organ injuries continues to progress and improve cost-effective utilization of resources while maximizing patient safety. The purpose of this study is to compare resource utilization and patient outcomes after changing admission criteria from a grade-based protocol to one based on hemodynamic stability.
While there is a plethora of research on people management and high-commitment management, most are focused on commercial enterprises. Even the high-commitment management literature on commercial organisations argues that we need to move beyond the confines of financial performance. There are relatively few studies of high-commitment management which focus on hospitals. This is despite the fact that human resources are a major cost and source of performance leverage in hospitals.
The Animal Transcription Factor DataBase (AnimalTFDB) is a resource aimed to provide the most comprehensive and accurate information for animal transcription factors (TFs) and cofactors. The AnimalTFDB has been maintained and updated for seven years and we will continue to improve it. Recently, we updated the AnimalTFDB to version 3.0 (http://bioinfo.life.hust.edu.cn/AnimalTFDB/) with more data and functions to improve it. AnimalTFDB contains 125,135 TF genes and 80,060 transcription cofactor genes from 97 ...
Our goal for this study was to quantify healthcare provider compliance with hand hygiene protocols and develop a conceptual framework for increasing hand hygiene compliance in a low-resource neonatal intensive care unit.
The human iPS cell line VUZUZLi001-A (hVH-1) was generated from human foreskin fibroblasts to be used as a control line. Reprogramming was performed by retroviral transduction of reprogramming factors OCT4, SOX2, KLF4 and c-MYC. Resource table.
Emergency management and operations (EMO) personnel require up-to-date information to make informed decisions during natural and man-made disasters. However, information gaps present challenges for accessing human health risk assessment and risk management strategies for dermal exposure. This article describes the development of a decision support system, the Dermal Exposure Risk Management and Logic (DERMaL) eToolkit.
Water management is a controversial environmental policy issue, due to the heterogeneity of interests associated with a shared resource and the increasing level of conflict among water uses and users. Nowadays, there is a cumulative interest in enhancing multi-stakeholder decision-making processes, overtaking binding mercantile business, in water management domain. This requires the development of dynamic decision-aiding tools able to integrate the different problem frames held by the decision makers, to cl...
Peripheral dermal fibroblasts (DF) from a healthy 56 year old female were obtained from the Centre for Healthy Brain Ageing (CHeBA) Biobank, University of New South Wales, under the material transfer agreement with the University of Wollongong. DFs were reprogrammed via mRNA-delivered transcription factors into induced pluripotent stem cells (iPSCs). The generated iPSCs were confirmed to be pluripotent, capable of three germ layer differentiation and are thus a useful resource for creating iPSC-derived he...
Purpose The purpose of this new resource-stratified guideline is to provide expert guidance to clinicians and policymakers on implementing palliative care of patients with cancer and their caregivers in resource-constrained settings and is intended to complement the Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update of 2016. Methods ASCO convened a multidisciplinary, multinational panel of experts in medical oncology, family m...
We specify a Bayesian, geoadditive Stochastic Frontier Analysis (SFA) model to assess hospital performance along the dimensions of resources and quality of stroke care in German hospitals. With 1,100 annual observations and data from 2006 to 2013 and risk-adjusted patient volume as output, we introduce a production function that captures quality, resource inputs, hospital inefficiency determinants and spatial patterns of inefficiencies. With high relevance for hospital management and health system regulator...
The management of end-of-life vehicles (ELVs) conserves natural resources, provides economic benefits, and reduces water, air, and soil pollution. In an effort to adequately manage flow of ELVs, modern infrastructure is considered a prerequisite. Thus, development of an effective performance evaluation tool for monitoring and continuous improvement of ELV management systems is strongly desired. In this paper, a performance evaluation tool is proposed for ELV management system implementation, based on the an...
Comprehensive and representative data on resource use is critical for health policy decision making but often lacking for HIV infection. Privacy preserving probabilistic record linkage of claim and cohort study data may overcome these limitations.
The Barcelona Principles: An Agreement on the use of human donated tissue for ocular transplantation, research, and future technologies (Agreement) is a global bioethical framework (GBF), developed by the eye bank and ophthalmic communities, to inform on the management of altruistic and voluntary donations; their subsequent utility within ophthalmology and research; their retention as a public resource for the shared benefit of all; and their accessibility by waiting recipients.The Agreement is the result o...
Interest in human mitochondrial genetic data is constantly increasing among both clinicians and researchers, due to the involvement of mitochondrial DNA (mtDNA) in a number of physiological and pathological processes. Thanks to new sequencing technologies and modern databases, the large amount of information on mtDNA variability may be exploited to gain insights into the relationship between mtDNA variants, phenotypes and diseases. To facilitate this process, we have developed the HmtVar resource, a variant...
Managing virologic failure (VF) in HIV-infected children is especially difficult in resource-limited settings, given limited availability of alternative drugs, concerns around adherence and the development of HIV resistance mutations. We aimed to evaluate four management strategies for children following their first episode of VF by comparing their immunologic and virologic outcomes.