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11:19 EDT 15th August 2018 | BioPortfolio

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Showing "Steps Editors Calling" PubMed Articles 26–50 of 1,700+

esATAC: An Easy-to-use Systematic pipeline for ATAC-seq data analysis.

ATAC-seq is rapidly emerging as one of the major experimental approaches to probe chromatin accessibility genome-wide. Here, we present "esATAC", a highly integrated easy-to-use R/Bioconductor package, for systematic ATAC-seq data analysis. It covers essential steps for full analyzing procedure, including raw data processing, quality control and downstream statistical analysis such as peak calling, enrichment analysis and transcription factor footprinting. esATAC supports one command line execution for pres...

Progressive Approach for SNP Calling and Haplotype Assembly Using Single Molecular Sequencing Data.

Haplotype information is essential to the complete description and interpretation of genomes, genetic diversity and genetic ancestry. The new technologies can provide Single Molecular Sequencing (SMS) data that cover about 90% of positions over chromosomes. However, the SMS data has a higher error rate comparing to 1% error rate for short reads. Thus, it becomes very difficult for SNP calling and haplotype assembly using SMS reads. Most existing technologies do not work properly for the SMS data.

Response to letter to the editors.

Preface: A letter from the guest editors.

Editors and Editorial Board.

Announcement of New Assistant Editors 2018.

Qualitative Exploration of the Feasibility and Acceptability of Workplace-based Microgrants to Improve Physical Activity: The 10,000 Steps Pedometer Microgrant Scheme.

Despite the benefits associated with workplace health programs, many organisations are unable to offer them due to financial constraints. To address this barrier, the existing 10,000 Steps program trialled the 10,000 Steps Pedometer Microgrant Scheme. This study assessed the feasibility and acceptability of the Microgrant Scheme.

A unified approach for the assembly of atisine- and hetidine-type diterpenoid alkaloids: Total syntheses of azitine and the proposed structure of navirine C.

A tetracyclic dinitrile was synthesized in 12 steps from cyclohex-2-en-1-one by using a chelation-triggered conjugate addition to g-hydroxy a,b-unsaturated nitrile and oxidative-dearomatization/Diels-Alder cycloaddition as the key steps. The first total synthesis of azitine (in 17 steps) was achieved through a simple reductive cyclization of this intermediate and subsequent transformations, while total synthesis of the proposed structure of navirine C (in 19 steps) was accomplished via a HAT reaction of the...

Editors of biomedical journals and the disclosure of their own conflicts of interest.

Editors' choice paper (Volume 23, 2017).

Analytical "bake-off" of whole genome sequencing quality for the Genome Russia project using a small cohort for autoimmune hepatitis.

A comparative analysis of whole genome sequencing (WGS) and genotype calling was initiated for ten human genome samples sequenced by St. Petersburg State University Peterhof Sequencing Center and by three commercial sequencing centers outside of Russia. The sequence quality, efficiency of DNA variant and genotype calling were compared with each other and with DNA microarrays for each of ten study subjects. We assessed calling of SNPs, indels, copy number variation, and the speed of WGS throughput promised. ...

Editors' Note: Call for Articles on Firearm-Related Harm.

From the Editors' Desk: Truth Rules, or the Upside of Bureaucracy.

hichipper: a preprocessing pipeline for calling DNA loops from HiChIP data.

Editors' Note: Paper Selected for the Mitchell B. Balter Award 2017.

Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines.

The Cancer Genome Atlas (TCGA) cancer genomics dataset includes over 10,000 tumor-normal exome pairs across 33 different cancer types, in total >400 TB of raw data files requiring analysis. Here we describe the Multi-Center Mutation Calling in Multiple Cancers project, our effort to generate a comprehensive encyclopedia of somatic mutation calls for the TCGA data to enable robust cross-tumor-type analyses. Our approach accounts for variance and batch effects introduced by the rapid advancement of DNA extra...

Emergency Manual Implementation in a Large Academic Anesthesia Practice: Strategy and Improvement in Performance on Critical Steps.

The use of cognitive aids, such as emergency manuals (EMs), improves team performance on critical steps during crisis events. In our large academic anesthesia practice, we sought to broadly implement an EM and subsequently evaluate team member performance on critical steps.

Step Numbers and Hoehn-Yahr Stage after Six Years.

Freezing of gait (FOG) has been linked to increased numbers of steps taken while walking. We tested the hypothesis that an increased number of steps associated with FOG might predict the exacerbation of the severity of Parkinson's disease (PD).

Awareness of Heart Attack Signs and Symptoms and Calling 9-1-1 Among U.S. Adults.

Coronary Flow Measurements in Clinical Practice: The Waves Are There, the Wind Is Calling.

Highly efficient RNA-guided base editing in rabbit.

Cytidine base editors (CBEs) and adenine base editors (ABEs), composed of a cytidine deaminase or an evolved adenine deaminase fused to Cas9 nickase, enable the conversion of C·G to T·A or A·T to G·C base pair in organisms, respectively. Here, we show that BE3 and ABE7.10 systems can achieve a targeted mutation efficiency of 53-88% and 44-100%, respectively, in both blastocysts and Founder (F0) rabbits. Meanwhile, this strategy can be used to precisely mimic human pathologies by efficiently inducing non...

Acknowledgement to Editors and Scientific Referees 2017.

Spotlights are papers selected by editors published in peer-reviewed journals that may be more regionally specific or appearing in languages other than English.

Correction to : Hip osteonecrosis: stem cells for life or behead and arthroplasty?

There is an error in the original publication for the photos of the Guest Editors were not included.

Introduction by the Guest Editors: The PD-1 Axis in Cancer Therapy: The Irony in a Name.

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