PubMed Journals Articles About "Brown Shoe Company" - Page: 2 RSS

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Showing "Brown Shoe Company" PubMed Articles 26–50 of 489

miR-199a-3p regulates brown adipocyte differentiation through mTOR signaling pathway.

Recent discoveries of functional brown adipocytes in mammals illuminates their therapeutic potential for combating obesity and its associated diseases. However, on account of the limited amount and activity in adult humans of brown adipocyte depots, identification of miRNAs and characterization their regulatory roles in human brown adipogenesis are urgently needed. This study focused on the role of microRNA (miR)-199a-3p in human brown adipocyte differentiation and thermogenic capacity. A decreased expressi...

Cell proliferation and anti-apoptosis: Essential processes for recruitment of the full thermogenic capacity of brown adipose tissue.

In mice living under normal animal house conditions, the brown adipocytes in classical brown adipose tissue depots are already essentially fully differentiated: UCP1 mRNA and UCP1 protein levels are practically saturated. This means that any further recruitment - in response to cold exposure or any other browning agent - does not result in significant augmentation of these parameters. This may easily be construed to indicate that classical brown adipose tissue cannot be further recruited. However, this is f...

Application of biomarkers in brown algae (Cystoseria indica) to assess heavy metals (Cd, Cu, Zn, Pb, Hg, Ni, Cr) pollution in the northern coasts of the Gulf of Oman.

In this study, selected biomarkers-Phytochelatin (PC) and Metallothionein (MT)- were measured in the brown algae (i.e., Cystoseria indica) obtained from the Gulf of Oman. Chemical analyses were performed to measure the concentration of heavy metals (Cd, Cu, Zn, Pb, Hg, Ni, and Cr) in the brown algae. Zn had the highest concentration followed by Cr>Ni>Cu>Pb>Cd>Hg. Performing a spatial analysis revealed that heavy metals had a significant difference (p 

Bioavailability of Silicon Fertilizer Coupled Water Management on Soil Bioavailability and Cumulative Control of Rice in Compound Contaminated Paddy Soils.

The effect of wet irrigation (CK), agronomic measure flooding (WF), instantaneous silicon fertilizer combined with flooding measures (FYsi), mineral silicon fertilizer combined with flooding measures (FKsi), and a mix of two kinds of silicon fertilizer combined with flooding measures (FYK) on the bio-availability of As and Cd in soil and the accumulation of As and Cd in rice were investigated by pot experiments. The results showed that the pH of the soils combined with flooding measures was increased by 0.1...

CREG1 promotes uncoupling protein 1 expression and brown adipogenesis in vitro.

Brown adipocytes play a critical role for adaptive thermogenesis to regulate body temperature in cold or to circumvent diet-induced obesity. In the present study, we investigated the role of cellular repressor of E1A-stimulated genes 1 (CREG1) on brown adipogenesis and uncoupling protein 1 (UCP1) expression by using in vitro culture models. In murine mesenchymal stem cell line C3H10T1/2, Creg1 mRNA expression significantly increased in a time-dependent manner along with Ucp1 mRNA induction in brown adipogen...

Microwave-assisted co-pyrolysis of brown coal and corn stover for oil production.

The controversial synergistic effect between brown coal and biomass during co-pyrolysis deserves further investigation. This study detailed the oil production from microwave-assisted co-pyrolysis of brown coal (BC) and corn stover (CS) at different CS/BC ratios (0, 0.33, 0.50, 0.67, and 1) and pyrolysis temperatures (500, 550, and 600 °C). The results showed that a higher CS/BC ratio resulted in higher oil yield, and a higher pyrolysis temperature increased oil yield for brown coal and coal/corn mixtures...

The Relationship between Shoe Fitting and Foot Health of Persons with Down Syndrome: A Case Control Study.

: Down syndrome is the most common chromosomal abnormality and a cause of intellectual disability. It is also associated with orthopaedic and musculoskeletal problems of the locomotive apparatus, especially of the feet. These problems are believed to have a harmful effect on health, social functioning, and mobility. In addition, these persons generally don't have access to podiatric health services, even when their foot problems are well known, because of limited access to healthcare facilities. The goal of...

Direct bioethanol production from brown macroalgae by co-culture of two engineered Saccharomyces cerevisiae strains.

A co-culture platform for bioethanol production from brown macroalgae was developed, consisting of two types of engineered Saccharomyces cerevisiae strains; alginate- and mannitol-assimilating yeast (AM1), and cellulase-displaying yeast (CDY). When the 5% (w/v) brown macroalgae Ecklonia kurome was used as the sole carbon source for this system, 2.1 g/L of ethanol was produced, along with simultaneous consumption of alginate, mannitol, and glucans.

Duration of a "Brown-Like" Phenotype of White Adipose Tissue Induced by the β3 Agonist CL-316,243.

"Browning" i. e. the transformation of white adipose tissue into brown-like adipose tissue could induce efficient burning of excess fat reserves via induction of non-shivering thermogenesis. For example, activation of ß3 adrenergic receptors has been show to induce such changes, however, it is still not clear, how long after termination of such a treatment, beneficial effects might be maintained. To address this question, we treated rats s.c. for 2 weeks with the ß3 agonist CL-316,243 at 1 mg/kg and a...

Emerging Role of AMPK in Brown and Beige Adipose Tissue (BAT): Implications for Obesity, Insulin Resistance, and Type 2 Diabetes.

The global prevalence of type 2 diabetes (T2D) is escalating at alarming rates, demanding the development of additional classes of therapeutics to further reduce the burden of disease. Recent studies have indicated that increasing the metabolic activity of brown and beige adipose tissue may represent a novel means to reduce circulating glucose and lipids in people with T2D. The AMP-activated protein kinase (AMPK) is a cellular energy sensor that has recently been demonstrated to be important in potentially ...

Notes from the Field: Lead Exposures Among Employees at a Bullet Manufacturing Company - Missouri, 2017.

Infrared Thermography.

Historically, brown adipose tissue has been elusive and not easy to detect, hence its relative obscurity in human physiology until its rediscovery in 2009. At that point, it was proven that the symmetrical artefacts frequently detected on positron emission tomography-computed tomography (PET-CT), which resolved if the environment was kept warm, were brown adipose tissue deposits. PET-CT has remained the stalwart of human brown adipose tissue research and is still considered the gold standard. However, PET-C...

Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis.

Various physiological stimuli, such as cold environment, diet, and hormones, trigger brown adipose tissue (BAT) to produce heat through sympathetic nervous system (SNS)- and β-adrenergic receptors (βARs). The βAR stimulation increases intracellular cAMP levels through heterotrimeric G proteins and adenylate cyclases, but the processes by which cAMP modulates brown adipocyte function are not fully understood. Here we described that specific ablation of cAMP production in brown adipocytes led to reduced li...

Relationship between rice consumption and body weight gain in Japanese workers: white versus brown rice/multigrain rice.

Increasing obesity rates have driven research into dietary support for body weight control, but previous studies have only assessed changes in body weight of ± 3 kg. We investigated the relationships between white or brown/multigrain rice consumption and one-year body weight gain ≥ 3 kg in Japanese factory workers (n = 437). Routine medical check-up data from a one-year nutrition and lifestyle cohort study were analysed. Participants were divided into white rice and brown/multigrain rice consumption grou...

Adipogenesis in Primary Cell Culture.

Obesity involves a contrasting expansion of the energy-storing white fat and loss of functionally competent brown fat, an energy-consuming thermogenic adipose. Leveraging our understanding of white and brown adipocyte recruitment and investigating factors that regulate these processes might reveal novel targets for counteracting obesity. In vitro differentiation of primary preadipocytes mimics many of the morphological and transcriptional events occurring during adipogenesis in vivo. Moreover, preadipocytes...

McGoldrick, M. (2016). The genogram casebook: A clinical companion to genograms: Assessment and intervention. New York, NY: W.W. Norton & Company, 304 pp., $32.00.

Seasonal Migration Pattern of Nilaparvata lugens (Hemiptera: Delphacidae) Over the Bohai Sea in Northern China.

The brown planthopper Nilaparvata lugens (Stål) (Hemiptera: Delphacidae) is a major, regionally migratory pest of rice crops in Asia. Despite intensive studies, the seasonal pattern of migration in this species remains largely unknown, especially in northern China. Analysis of monitoring data of light trapping at Beihuang island in northern China showed that brown planthopper migrants could be found at the island in any month from July to October. However, the daily number of brown planthopper migrants var...

Impact of fenofibrate on choroidal neovascularization formation and VEGF-C plus VEGFR-3 in Brown Norway rats.

This study aims to explore the possible role of fenofibrate in inhibiting choroidal neovascularization (CNV) in Brown Norway (BN) rats.

VEGF and VEGFB Play Balancing Roles in Adipose Differentiation, Gene Expression and Function.

Obesity is the results of abnormal adipose development and energy metabolism. Using VEGFB knockout and inducible VEGF down regulation mouse models, we have shown that VEGFB inactivation caused expansion of white adipose, whitening of brown adipose, increase of fat accumulation and reduction of energy consumption. At the same time, expression of the white adipose-associated genes was increased and brown adipose-associated genes decreased. VEGF repression, in contrary, induced brown adipose expansion and brow...

Norepinephrine and thyroxine are predictors of fat mass gain in humans with cold-induced brown adipose tissue activation.

In healthy adults with detectable cold-induced brown fat activation (CIBA), the relationships between sympathetic nervous system (SNS) or thyroid activity during energy balance (EBL) with CIBA and body composition change are undetermined.

Palmitoyl lactic acid induces adipogenesis and a brown fat-like phenotype in 3T3-L1 preadipocytes.

Brown adipose tissue is specialized to generate heat by dissipating chemical energy and may provide novel strategies for the defense against human obesity. Recent advances have been made in the understanding of pharmacological and dietary agents that contribute to the browning of white adipose tissue to alleviate obesity by promoting energy expenditure. Krill oil is widely used as a human health supplement. In this study, we screened components from krill oil that promote adipogenesis of 3T3-L1 cells identi...

An Improved Analytical Method for the Determination of Brown FK in Food using HPLC.

In this study, an improved analytical method for the detection of the colorant Brown FK in foods using high-performance liquid chromatography was developed. The method, which employed an RC-C18 column and diode array detection at 254 nm with sodium acetate solution and methanol as mobile phases, exhibited good linearity (R2 = 1.0), and its limits of detection and quantification were determined to be 0.06 and 0.19 μg/mL, respectively. The precision was found to be 0-1.2% and the accuracy was between 86.5% a...

Impact of a (poly)phenol-rich extract from the brown algae Ascophyllum nodosum on DNA damage and antioxidant activity in an overweight or obese population: a randomized controlled trial.

Epidemiologic evidence suggests that a diet rich in (poly)phenols has beneficial effects on many chronic diseases. Brown seaweed is a rich source of (poly)phenols.

Development of a Footwear Sizing System in the National Football League.

Footwear performance and injury mitigation may be compromised if the footwear is not properly sized for an athlete. Additionally, poor fit may result in discomfort and foot injury such as fifth metatarsal stress fracture, foot deformities, turf toe, and blisters. Current footwear fitting methods consist of foot length and width measurements, which may not properly describe the shape of the individual foot, correlated with shoe size descriptors that are not standardized. Footwear manufacturers employ a range...

Longer-term effects of minimalist shoes on running performance, strength and bone density: A 20-week follow-up study.

This study investigated whether male runners improve running performance, running economy, ankle plantar flexor strength, and alter running biomechanics and lower limb bone mineral density when gradually transitioning to using minimalist shoes for 100% of weekly running. The study was a planned follow-up of runners (n = 50) who transitioned to minimalist or conventional shoes for 35% of weekly structured training in a previous 6-week randomised controlled trial. In that trial, running performance and ec...

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