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PubMed Journals Articles About "Catalent Appoints Advisory Board" - Page: 14 RSS

08:18 EST 22nd November 2019 | BioPortfolio

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Showing "Catalent appoints advisory board" PubMed Articles 326–350 of 362

A Last-Ditch Effort and Personalized Surgeon Letter Improves PROMs Follow-Up Rate in Sports Medicine Patients: A Crossover Randomized Controlled Trial.

Patient-reported outcomes measures (PROMs) are important for the advancement of orthopaedic surgeries. The primary difficulty while collecting PROMs is obtaining adequate follow-up rates. Therefore, it is important to find methods to improve follow-up, especially in patients who have failed to respond to initial attempts. We hypothesized that PROMs follow-up could be effectively increased by sending a salvage-effort personalized surgeon letter to sports medicine patients who failed to respond to initial (ce...


A Wearable Skin-Like Ultra-Sensitive Artificial Graphene Throat.

Most mute people cannot speak due to their vocal cord lesion. Herein, in order to assist mute people to "speak", we proposed a wearable skin-like ultra-sensitive artificial graphene throat (WAGT) that integrated both sound/motion detection and sound emission in single device. In this work, the growth and patterning of graphene can be realized at the same time, and a thin polyvinyl alcohol (PVA) film with laser scribed graphene (LSG) was obtained by a water-assisted transferring process. In virtue of the ski...

The American Cancer Society 2035 challenge goal on cancer mortality reduction.

A summary evaluation of the 2015 American Cancer Society (ACS) challenge goal showed that overall US mortality from all cancers combined declined 26% over the period from 1990 to 2015. Recent research suggests that US cancer mortality can still be lowered considerably by applying known interventions broadly and equitably. The ACS Board of Directors, therefore, commissioned ACS researchers to determine challenge goals for reductions in cancer mortality by 2035. A statistical model was used to estimate the av...


Single-Center Prospective Evaluation of Ga-PSMA-11 PET in Biochemical Recurrence of Prostate Cancer.

The purpose of this study was to determine the diagnostic accuracy of Ga-labeled prostate-specific membrane antigen 11 (PSMA-11) PET for disease detection in patients with prostate cancer who have biochemically recurrent disease after radiation therapy or prostatectomy. One hundred fifty patients underwent 68Ga-PSMA-11 PET/CT or PET/MRI, and the images were interpreted by two blinded board-certified radiologists. Each reader evaluated for the presence or absence of PSMA-positive disease within the prostate...

MATHEMATICAL MODELING OF ТHE FUNCTIONING OF THE MEDICAL MANAGEMENT OF THE RA POLICE.

The organizational aspects of the public health department in the police system play an important role and are of fundamental importance for the preservation and improvement of employees' health. The purpose of this research is to improve the medical support of the Police of the Republic of Armenia on the basis of mathematical modeling of the activities of its various structures and their psycho-emotional state and appealability, morbidity and expert's judgment of validity. The object of the research were t...

Developing Large-Scale Research in Response to an Oil Spill Disaster: a Case Study.

Research conducted in the wake of a disaster can provide information to help mitigate health consequences, support future recovery efforts, and improve resilience. However, a number of barriers have prevented time-sensitive research responses following previous disasters. Furthermore, large-scale disasters present their own special challenges due to the number of people exposed to disaster conditions, the number of groups engaged in disaster response, and the logistical challenges of rapidly planning and im...

Serotonin receptors in the dorsal hippocampus regulate working memory and long-term habituation in the hemiparkinsonian rats.

Although the dorsal hippocampus (dHPC) and serotonin (5-HT) receptor are involved in cognition, their roles in cognitive impairments in Parkinson' disease (PD) are still unclear. In the present study, the effects of the 5-HT receptor agonist 8-OH-DPAT and antagonist WAY100635 administrated into the dHPC of rats were assessed in T-maze rewarded alternation test for working memory and in hole-board test for long-term habituation. Unilateral 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle in ...

The Leaky Pipeline of Women in Plastic Surgery: Embracing Diversity to Close the Gender Disparity Gap.

On March 8, 2019, we celebrated International Women's Day, a global day, which honors social, economic, cultural, and political achievements of women while simultaneously turning our attention toward the continued lack of gender balance present in today's world. The Balance for Better campaign theme prompted a closer look at diversity within our plastic surgery specialty. Gender balance has improved with many organizational efforts and laws enacted in the United States. Unfortunately, despite these institut...

Event-driven implementation of deep spiking convolutional neural networks for supervised classification using the SpiNNaker neuromorphic platform.

Neural networks have enabled great advances in recent times due mainly to improved parallel computing capabilities in accordance to Moore's Law, which allowed reducing the time needed for the parameter learning of complex, multi-layered neural architectures. However, with silicon technology reaching its physical limits, new types of computing paradigms are needed to increase the power efficiency of learning algorithms, especially for dealing with deep spatio-temporal knowledge on embedded applications. With...

REDUCING INAPPROPRIATE SERUM T3 LABORATORY TEST ORDERING IN PATIENTS WITH TREATED HYPOTHYROIDISM.

: Choosing Wisely is a campaign of the American Board of Internal Medicine that aims to promote evidence-based practices to reduce unnecessary ordering of tests or procedures. As part of this campaign, the Endocrine Society advises against ordering a serum total or free triiodothyronine (T3) level when assessing levothyroxine dosing in hypothyroid patients. This study was performed to assess and reduce inappropriate laboratory ordering practices among providers who manage patients with hypothyroidism within...

Looking at the bigger picture: effect of performance-based contracting of district health services on equity of access to maternal health services in Zambia.

Zambia has been using output-based approaches for over two decades to finance whole or part of the public health system. Between 1996 and 2006, performance-based contracting (PBC) was implemented countrywide with the Central Board of Health (CBoH) as the provider of health services. This study reviews the association between PBC and equity of access to maternal health services in Zambia between 1996 and 2006. A comprehensive document review was undertaken to evaluate the implementation process, followed by ...

Molecular tumor board-renal cell carcinoma.

The introduction of molecular targeted agents has fundamentally changed the treatment of metastatic renal cell carcinoma. A first wave of development was based on the improved understanding of tumor biology since the discovery of the importance of the von Hippel-Lindau gene as the key driver of the disease and paved the way for antiangiogenic agents. Of relevance is the overexpression of proangiogenic and proliferation-promoting factors (VEGF, vascular endothelial growth factor; PDGF, platelet-derived grow...

LAPAROSCOPIC EXCISION OF A 5-CM RETROAORTIC RELAPSE OF OVARIAN CANCER.

To demonstrate the feasibility of laparoscopic secondary cytoreduction of isolated lymph node relapse of ovarian carcinoma DESIGN: A video explanation of a safe excision of ovarian cancer relapse using pictures to show the anatomic landmark of the retroperitoneum guiding the procedure SETTING: Department of Obstetrics and Gynaecology. "Ospedale degli Infermi" Hospital - Biella, Italy. The video was approved by the local institutional review board INTERVENTIONS: A 61-year-old woman was referred to our center...

Remotely sensing harmful algal blooms in the Red Sea.

Harmful Algal Blooms (HABs) are of global concern, as their presence is often associated with socio-economic and environmental issues including impacts on public health, aquaculture and fisheries. Therefore, monitoring the occurrence and succession of HABs is fundamental for managing coastal regions around the world. Yet, due to the lack of adequate in situ measurements, the detection of HABs in coastal marine ecosystems remains challenging. Sensors on-board satellite platforms have sampled the Earth synopt...

Strategies to Improve Case Outcome When Referral Is Not Affordable.

We conducted a survey-based study to determine whether on-site consultations and cost-effective protocols are beneficial to general practitioners handling challenging small animal internal medicine patients when owners cannot afford referral and whether fourth-year veterinary students benefit from training in this area. Fifteen general practices were visited over 12 months by a board-certified internist and students. On-site consultations for patients belonging to owners who could not afford referral were c...

The Photochemistry on Space Station (PSS) Experiment: Organic Matter under Mars-like Surface UV Radiation Conditions in Low Earth Orbit.

The search for organic molecules at the surface of Mars is a top priority of the Mars Science Laboratory (NASA) and ExoMars 2020 (ESA) space missions. Their main goal is to search for past and/or present molecular compounds related to a potential prebiotic chemistry and/or a biological activity on the Red Planet. A key step to interpret their data is to characterize the preservation or the evolution of organic matter in the martian environmental conditions. Several laboratory experiments have been developed...

A MULTICENTER STUDY EVALUATING PERCEPTIONS AND KNOWLEDGE OF INPATIENT GLYCEMIC CONTROL AMONG RESIDENT PHYSICIANS: ANALYZING THEMES TO INFORM AND IMPROVE CARE.

In this descriptive study, we evaluated perceptions and knowledge of inpatient glycemic control among resident physicians. We performed this study at four academic medical centers: the University of Mississippi Medical Center, University of Virginia Health System, University of Louisville Health Sciences Center, and Emory University. We designed a questionnaire and Institutional Review Board approval was granted at each institution prior to study initiation. We then administered the questionnaire to Intern...

Diagnosis and treatment of basal cell carcinoma: European consensus-based interdisciplinary guidelines.

Basal cell carcinoma (BCC) is the most common malignant tumour in white populations. Multidisciplinary experts from the European Dermatology Forum, the European Association of Dermato-Oncology and the European Organization of Research and Treatment of Cancer collaborated to develop recommendations on diagnosis and treatment of BCC. A new classification into 'easy-to-treat (common) BCC and 'difficult-to-treat' BCC is proposed. Diagnosis is based on clinicodermatoscopic features for 'easy-to-treat' BCCs. Hist...

Learners as Leaders: A Global Groundswell of Students Leading Choosing Wisely Initiatives in Medical Education.

Resource stewardship and reducing low-value care have emerged as urgent priorities for health care delivery systems worldwide. However, few medical school curricula include adequate content to allow learners to master the knowledge, skills, and attitudes needed to contribute to this transformation toward value-based health care. This article describes a program to launch student-led curriculum enhancement initiatives in 7 countries. The program, called STARS (Students and Trainees Advocating for Resource St...

Rationale and design of a navigator-driven remote optimization of guideline-directed medical therapy in patients with heart failure with reduced ejection fraction.

Although optimal pharmacological therapy for heart failure with reduced ejection fraction (HFrEF) is carefully scripted by treatment guidelines, many eligible patients are not treated with guideline-directed medical therapy (GDMT) in clinical practice. We designed a strategy for remote optimization of GDMT on a population scale in patients with HFrEF leveraging nonphysician providers. An electronic health record-based algorithm was used to identify a cohort of patients with a diagnosis of heart failure (HF)...

The futility of continued surveillance of epididymal cysts - A study of the prevalence and clinico-demographics in pre- vs. post-pubertal boys.

The first description of epididymal cysts in children appears from a 1976 case study. Since then, there have been a total of 24 indexed publications relating to pediatric epididymal cysts. Risk factors that may exist for children presenting with epididymal cyst remain unknown, as has the best method of management. And there have not been any studies looking at the cost implications of this diagnosis. The aim of this study was to assess the incidence, clinico-demographics, outcomes, and costs of epididymal c...

Plug and play self-configurable IoT gateway node for telemonitoring of ECG.

In the era of IoT and hyperconnection, an efficient electrocardiogram (ECG) telemonitoring system in wireless body area network (WBAN) demands an easy to use, self-configurable, secure, plug and play system with minimum hardware and computational complexities. The compression and quantization parameters required for an efficient representation of ECG signal will vary from patient to patient, from lead to lead, and from time to time. To this end, we propose a compressed sensing based WBAN with self-configura...

The other explanation for dyspnea: giant paraesophageal hiatal hernia repair routinely improves pulmonary function.

Paraesophageal hiatal hernias (PEHs) are most commonly associated with gastrointestinal symptoms; less widely appreciated is their potentially important influence on respiratory function. We hypothesize that surgical repair of PEH will significantly improve not only gastrointestinal symptoms, but also preoperative dyspnea and spirometry scores. A prospective Institutional Review Board-approved database was used to review all patients undergoing PEH repair from 2000 to 2016. Patients with pre- and postoperat...

EORTC SPECTA-AYA: A unique molecular profiling platform for adolescents and young adults with cancer in Europe.

For most adolescent and young adult (AYA) cancers, age-specific molecular features are poorly understood. SPECTA, an academic translational research infrastructure for biomaterial collection, will explicitly recruit AYA patients and will therefore collect empirical data to bridge the molecular gap between pediatric and adult oncology. The initial pilot study, activated in Feb-2019 across Europe, will recruit 100 AYA patients (aged 12-29 years) with newly diagnosed or relapsed high-grade gliomas and high-g...

Development, application and evaluation of a 1-D full life cycle anchovy and sardine model for the North Aegean Sea (Eastern Mediterranean).

A 1-D full-life-cycle, Individual-based model (IBM), two-way coupled with a hydrodynamic/biogeochemical model, is demonstrated for anchovy and sardine in the N. Aegean Sea (Eastern Mediterranean). The model is stage-specific and includes a 'Wisconsin' type bioenergetics, a diel vertical migration and a population dynamics module, with the incorporation of known differences in biological attributes between the anchovy and sardine stocks. A new energy allocation/egg production algorithm was developed, allowin...


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